Lyle L. Moldawer, PhD

Professor, Vice Chairman of Research
Laboratory of Inflammation Biology and Surgical Science

phone: (352) 265-0494
fax: (352) 265-0676

Awards and Professional Interests - Research/Clinical Interests
Research Projects - References - Biosketch - Links
Awards and Professional Interests
  • University of Florida, College of Medicine, Faculty Research Prize in Basic Science, 2004
  • Blue Key Distinguished Faculty Award, 1999
  • University of Florida Bank Award for Highly Marketable Faculty, 1999
  • NIH/NIGMS MERIT Award, R37-GM-40586-11, 1998-2006
  • Lester Dragstedt Scientist-Physician Award, 1998
  • University of Florida Bank Award for Excellence in Research, 1997
  • Utbildningsbidrag (Educational Scholarship), H.G. Larssons and S.R. Kjellsons Foundation, Goteborgs Universitet, Goteborg Sweden, 1986
  • Ad Hoc Member, Surgery Anesthesiology and Trauma Study Section, 2000-2002
  • Travel Award, Knut and Alice Wallenberg Foundation, Goteborg, Sweden, 1986
  • Member, Special Emphasis Panel, NIEHS, 1999
  • Special Member, Veterans Affairs/Defense Department Merit Review Committee for Combat Casualty Care and Wound Repair, Department of Veterans Affairs, 1998
  • Special Member, Post-Graduate Research and Training Grants IRG, NIGMS, 1996-1997
  • Regular Member, Metabolic Pathology Study Section, DRG, 1995-1999
  • External Reviewer, Scientific Review Group, Metabolism Study Section, 1999
  • Member, Special Scientific Review Group, DK94-06, Pathogenesis of Wasting in AIDS, NIDDK, 1994
  • Member, Special Scientific Review Group, Burn and Trauma Program Project Review, Biophysics and Biophysiology Division, National Institutes of General Medical Sciences. 1989, 1991-1998, Chairperson, 1999.
  • Member, Editorial Board, Journal of Parenteral and Enteral Nutrition, 1991-2001
  • Member, Editorial Board, Lymphokine and Cytokine Research, 1993-1995
  • Member, Editorial Board, Journal of Interferon and Cytokine Research, 1995-1998
  • Member, Editorial Board, Critical Care Nutrition and Medicine, 1995-
  • Member, Editorial Board, American Journal of Physiology, Regulatory, Comparative and Developmental Physiology, 1999-
  • Member, Editorial Advisory Board, Current Gene Therapy, 2001-
  • Member, Editorial Board, Shock, 1994-
  • Section Editor, Current Opinion in Clinical Nutrition and Metabolic Care, 2001-
  • Member, Editorial Board, Surgical Infections, 1999-2000

Research/Clinical Interests
  • Dr. Moldawer has pursued the role that dysregulation between proinflammatory cytokine and cytokine inhibitor production plays in the pathologic host response to acute inflammatory processes, such as sepsis and systemic inflammatory response syndromes, and to chronic inflammatory processes, such as cancer and AIDS-associated cachexia.
Research Projects
  • Dr. Moldawer has received independent funding from the National Institutes of Health (NIH) continuously since 1988. In 1998, Dr. Moldawer received the prestigious Merit Award from the National Institute of General Medical Sciences, extending his current NIH support through the year 2006. Dr. Moldawer is the principal investigator on a training grant from the NIH to prepare surgical residents in training with a two year research experience in molecular biology and gene therapy. Dr. Moldawer is one of only a small number of Ph.D.'s in the country who holds the academic rank of Full Professor in a Department of Surgery. Since 1988, Dr. Moldawer has trained 28 surgical residents in research methodologies (19 of which at the University of Florida). Sixteen of these surgical residents have continued in academic training programs, and eight are currently on the faculty of colleges of medicine.

References
  1. Ginsberg, H., Moldawer, L.L., Sehgal, P.B, Redington, M., Kilian, P.L., Chanock, R.M., Prince, G.A. A unique mouse model to investigate the molecular pathogenesis of adenovirus pneumonia. Proc. Natl. Acad. Sci 88:1651-1655, 1991
  2. Fischer, E., Poutsiaka, D.D., Van Zee, K.J., Marano, M.A., Rock, C.S., Kenney, J.S., Dinarello, C.A., Lowry, S.F., Moldawer, L.L. Interleukin-1 receptor antagonist circulates in experimental inflammation and in human disease. Blood 79:2196-2200, 1992.
  3. Fischer, E., Marano, M.A., Van Zee, K.J., Rock, C.S., Hawes, A.S., Thompson, W.A., DeForge, L., Kenney, J.S., Remick, D.G., Bloedow, D.C., Thompson, R.C., Lowry, S.F., Moldawer, L.L. Interleukin-1 receptor blockade improves survival and hemodynamic performance in Escherichia coli septic shock, but fails to alter host responses to sublethal endotoxemia. J. Clin.Invest. 89:1551-1557, 1992.
  4. Van Zee, K.J., Kohno, T., Fischer, E., Rock, C.S., Moldawer, L.L., Lowry, S.F. TNF soluble receptors protect against excessive TNF during infection and injury. Proc. Natl. Acad.Sci. 89:4845-4849, 1992.
  5. Rogy, M., Auffenburg, T., Espat, N.J., Philip, R., Remick, D.J., Wollenburg, G.K., Copeland, E.M., Moldawer, L.L. Human TNF receptor and interleukin-10 gene transfer in the mouse reduces mortality to lethal endotoxemia and also attenuates local inflammatory responses. J. Exp.Med. 181:2289-2293, 1995.
  6. Van Zee, K.J., Stackpole, S.A., Montegut, W.J., Rogy, M.A., Calvano, S.E., Hsu, K.C., Chao, M., Loetscher, H., Stuber, D., Ettlin, U., Wipf, B., Lesslauer, W., Lowry, S.F. Moldawer, L.L. A human tumor necrosis (TNF) mutant that binds exclusively to the p55 TNF receptor produces toxicity in the baboon. J. Exp. Med. 179:1185-1191, 1994.
  7. Solorzano, C.C., Ksontini, R., Pruitt, J.H., Hess, P.J., Edwards, P.D., Kaibara, A ., Abouhamze,A., Auffenberg, T., Galardy, R.E., Vauthey,J.N., Copeland, E.M., III., Edwards, C.K., III., Lauwers, G.Y., Clare-Salzler, M., MacKay, S.L.D., Moldawer, L.L. and Lazarus, D.D. Involvement of 26 kD cell-associated TNF in experimental hepatitis and exacerbation of liver injury with a matrix-metalloproteinase inhibitor. J.Immunol. 158:414-419, 1997.
  8. Labow, M., Shuster, D., Zetterstrom, M., Nunes, P., Terry R., Cullinan, E.B., Bartfai, T., Solorzano, C., Moldawer, L.L., Chizzonite, R., McIntyre, K.W. Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice. J. Immunol. 159(5):2452-2461, 1997.
  9. van der Poll, T., Jansen, P.M., Montegut, W.J., Braxton, C.C., Calvano, S.E., Stackpole, S.A., Smith, S.M., Swanson, S.W., Hack, C.E., Lowry, S.F., Moldawer, L.L.. Effects of IL-10 on systemic inflammatory responses during sublethal primate endotoxemia. J. Immunol., 158:1971-1975, 1997.
  10. Ksontini, R., Colagiovanni, D.B., Josephs, M.D., Edwards, C.K. 3rd, Tannahill, C.L., Solorzano, C.C., Norman, J., Denham, W., Clare-Salzler, M., MacKay, S.L., Moldawer, L.L. Disparate roles for TNF- and Fas ligand in concanavalin A-induced hepatitis. J. Immunol., 160:4082-4089, 1998.
  11. Solorzano, C.C., Kaibara, A., Hess, P.J., Edwards, P.D., Ksontini, R., Abouhamze, A., McDaniel, S., Frazier, J., Trujillo, D., Kieft, G., Seely, J., Kohno, T., Cosenza, M.E., Clare-Salzler, M., MacKay, S.L.D., Martin, S.W., Moldawer, L.L., Edwards, C.K. 3rd. Pharmacokinetics, immunogenicity, and efficacy of dimeric TNFR binding proteins in healthy and bacteremic baboon. J. Appl.Physiol. 84:1119-1130, 1998.
  12. Ginsberg, H.S., Moldawer, L.L., Prince, G.A. Role of the type 5 adenovirus gene encoding the early region E1B 55kD protein in pulmonary pathogenesis. Proc. Natl. Acad. Sci. (USA) 96(18):10409-11, 1999.
  13. Minter, R.M., Rectenwald, J.E., Fukuzuka, K., LaFace, D., Tsai, V., Hutchins, E., Moyer, R., Moldawer , L.L. TNF receptor signaling and interleukin-10 gene therapy regulate the innate and humoral immune responses to recombinant adenovirus in the lung. J Immunology 164(1):443-451; 2000.
  14. Fukuzuka, K., Edwards, C.K., Clare-Salzler, M., Copeland, E.M. III, Moldawer , L.L., Mozingo, D.W. Glucocorticoid induced, caspase-dependent organ apoptosis early after burn injury. Am J Physiol 278:R1005-18; 2000.
  15. Josephs, M.D., Bahjat, F.R., Fukuzuka, K., Ksontini, R., Solorzano, C.C., Edwards, C.K. III, Tannahill, C.L., MacKay, S.L.D., Copeland, E.M. III, Moldawer , L.L. Lipopolysaccharide and d-galactosamine-induced hepatic injury is mediated by TNF and not by fas ligand. Am J Physiol 278(5):R1196-201; 2000.
  16. Nowak, M., Gaines, G.C., Rosenberg, J., Minter, R., Bahjat, F.R., Rectenwald, J., MacKay, S.L.D., Edwards, C.K. III, Moldawer , L.L. Lipopolysaccharide-induced liver injury in D-galactosamine-sensitized mice requires secreted TNF and the TNF p55 receptor. Am J Physiol, 278(5):R1202-9; 2000
  17. Norman, J., Denham, W., Denham, D., Yang, J., Carter, G., Abouhamze, A., Tannahill, C.L., MacKay,S.L.D., Moldawer , L.L. Liposome mediated, nonviral gene transfer induces a systemic inflammatory response which can exacerbate pre existing inflammation. Gene Therapy, 7:1425-30, 2000.
  18. Minter R.M.,, Ferry M.A., Rectenwald, J.E., Bahjat F.R., Oberholzer, A., Oberholzer, C., LaFace D., Tsai V., Ahmed, C.M.I., Hutchins B., Copeland E.M., and Moldawer L.L. Extended lung expression and increased tissue localization of viral IL-10 with adenoviral gene therapy Proc. Natl Acad. Scienc. 98(1):277-282, 2001.
  19. Oberholzer, A., Oberholzer, C., Minter, R.M., Moldawer, L.L. Considering immunomodulatory therapies in the septic patient: should apoptosis be a potential therapeutic target. Immunology Letters, 75(3):221-4, 2001.
  20. Oberholzer, C., Oberholzer, A., Clare-Salzler, M., Moldawer, L.L. Apoptosis in sepsis: a new target for therapeutic exploration. FASEB Journal 15(6):879-92, 2001.
  21. Oberholzer, A., Oberholzer, C., Moldawer, L.L. Interleukin-10: A complex role in the pathogenesis of sepsis syndromes and its potential as an anti-inflammatory drug. Crit Care Med 30(1 Supp):S56-S63, 2002.
  22. Oberholzer, A., Oberholzer, C., Bahjat, K., Ungaro, R., Tannahill, C.L., Murday, M., Bahjat, F.R., Abouhamze, Z., LaFace, D., Hutchins, B., Moldawer, L.L., Clare-Salzler, M.J. Increased survival in sepsis by in vivo adenovirus-induced expression of IL-10 in dendritic cells. J Immunology 168(7):3412-8, 2002.
  23. Hoefer, I.E., van Royen, N., Rectenwald, J.E., Bray, E.J., Abouhamze, Z., Moldawer, L.L., Voskuil, M., Piek, J.J., Buschmann, I.R., Ozaki, C.K. Direct evidence for tumor necrosis factor-alpha signaling in arteriogenesis. Circulation 105(14):1639-41, 2002.
  24. Barth, E., Fischer, G., Schneider, E.M., Moldawer, L.L., Georgieff, M. Peaks of endogenous g-csf serum concentrations are followed by an increase in respiratory burst activity of granulocytes in patients with septic shock. Cytokine 17(5):275-84, 2002.
  25. Paddock, H., Moldawer, L. Humoral products from tumor necrosis factor-α-stimulated neutrophils suppress neutrophil function: Shedding new light on paracrine signaling. Crit Care Med 30(3):716-7, 2002.
  26. Li, J., Kokkola, R., Tabibzadeh, S., Yang, R., Ochani, M., Qiang, X., Harris, H.E., Czura, C.J., Wang, H., Ulloa, L., Wang, H., Warren, H.S., Moldawer, L.L., Fink, M.P., Andersson, U., Tracey, K.J., Yang, H. Structural basis for the proinflammatory cytokine activity of high mobility group box 1. Mol Med 9(1-2):37-45, 2003.
  27. Welborn, M.B. 3rd, Moldawer, L.L., Seeger, J.M., Minter, R.M., Huber, T.S. Role of endogenous interleukin-10 in local and distant organ injury after visceral ischemia-reperfusion. Shock 20(1):35-40, 2003.
  28. Lam, T., Ling, T., Chowdhury, C., Chao, T., Bahjat, F.R., Lloyd, G.K., Moldawer, L.L., Palladion, M.A., Theodorakis, E.A. Synthesis of a novel family of diterpenes and their evaluation as anti-inflammatory agents. Bioorganic & Medicinal Chemistry Ltrs 13(19):3217-21, 2003.
  29. Palladino, M.A., Bahjat, F.R., Theodorakis, E.A., Moldawer, L.L. Anti-TNF-alpha therapies: the next generation. Nat Rev Drug Discov 2(9):736-46, 2003.
  30. Efron, P.A., Moldawer, L.L. Blocking interleukin-18: a tumor necrosis factor-alpha lesson already learned. Crit Care Med 31(8):2241-2, 2003.
  31. Feezor, R.J., Oberholzer, C., Baker, H.V., Novick, D., Rubinstein, M., Moldawer, L.L., Pribble, J., Souza, S., Dinarello, C.A., Ertel, W., Oberholze,r A. Molecular characterization of the acute inflammatory response to infections with gram-negative versus gram-positive bacteria. Infect Immun 71(10):5803-13, 2003.
  32. Efron P., Moldawer L.L. Sepsis and the dendritic cell. Shock 20(5):386-401, 2003.
  33. Paddock, H.N., Schultz, G.S., Baker, H.V., Varela, J.C., Beierle, E.A., Moldawer, L.L., Mozingo, D.W. Analysis of gene expression patterns in human postburn hypertrophic scars. J Burn Care Rehabil 24(6):371-7, 2003.
  34. Feezor, R.J., Paddock, H.N., Baker, H.V., Varela, J.C., Barreda, J., Moldawer, L.L., Schultz, G.S., Mozingo, D.W. Temporal patterns of gene expression in murine cutaneous burn wound healing. Physiol Genomics.16(3):341-8, 2004.
  35. Efron PA, Moldawer LL. Cytokines and wound healing: the role of cytokine and anticytokine therapy in the repair response. J Burn Care Rehabil. Mar-Apr;25(2):149-60, 2004.
  36. Litherland SA, Xie TX, Grebe KM, Li Y, Moldawer LL, Clare-Salzler MJ. IL10 resistant PGS2 expression in at-risk/Type 1 diabetic human monocytes. J Autoimmun. May;22(3):227-33, 2004.
  37. Blenman KR, Bahjat FR, Moldawer LL, Morel L. Aberrant signaling in the TNFalpha/TNF receptor 1 pathway of the NZM2410 lupus-prone mouse. Clin Immunol. Feb;110(2):124-33, 2004.
  38. Efron PA, Tinsley K, Minnich DJ, Monterroso V, Wagner J, Lain e P, Lorr K, Swanson PE, Hotchkiss R, Moldawer LL. Increased lymphoid tissue apoptosis in baboons with bacteremic shock. Shock, June;21(6):566-571, 2004.
  39. Feezor RJ, Baker HV, Wenzhong X, Lee WA, Huber TS, Mindrinos M, Kim RA, Ruiz-Taylor L, Moldawer LL, Davis RW, Seeger JM. Genomic and proteomic determinants of outcome in patients undergoing thoracoabdominal aortic aneurysm repair. The Journal of Immunology. June ;172(11):7103-9, 2004.
  40. Reinhart K, Gluck T, Ligtenberg J, Tschaikowsky K, Bruining A, Bakker J, Opal S, Moldawer LL, Axtelle T, Turner T, Souza S, Pribble J. CD14 receptor occupancy in severe sepsis: results of a phase I clinical trial with a recombinant chimeric CD14 monoclonal antibody (IC14). Crit Care Med. 2004 May;32(5):1100-8.
  41. Voboril R., Hochwald S.N., Li J., Brank A., Weberova J., Wessels F., Moldawer L.L., Camp R.E., MacKay S.L. Inhibition of NF-Kappa B augments sensitivity to 5-Fluotouracil/Folinic acid in colon cancer (1). J Surg Res Aug;120(2):178-88, 2004.
  42. Camp, E.R., Li, J., Minnich, D.J., Brank, A., Moldawer, L.L., MacKay, S.L., Hochwald, S.N. Inducible nuclear factor-kappaB activation contributes to chemotherapy resistance in gastric cancer. J Am Coll Surg Aug;199(2):249-58, 2004.
  43. Efron PA, Martins A, Minnich D, Tinsley K, Ungaro R, Bahjat FR, Hotchkiss R, Clare-Salzler M, Moldawer LL. Characterization of the Systemic Loss of Dendritic Cells in Murine Lymph Nodes During Polymicrobial Sepsis. J of Immunology Sep;173(5):3035-43, 2004.
  44. Oldenburg, H.S., Siroen, M.P., Boelens, P.G., Sluijter, B.J., Pruitt, J.H., Naseri, A.H., Rauwerda, J.A., Meijer, S., Cuesta, M.A., van Leeuwen, P.A., Moldawer, L.L. Aortic aneurysm repair is associated with a lower inflammatory response compared with surgery for inflammatory bowel disease. Eur Surg Res Sep-Oct;36(5):266-73, 2004.
  45. Minnich, D.J., Moldawer, L.L. Anti-cytokine and anti-inflammatory therapies for the treatment of severe sepsis: progress and pitfalls. Proc Nutr Soc Aug;63(3):437-41, 2004.
  46. Sethu, P., Anahtar, M., Moldawer, L.L., Tompkins, R.G., Toner, M. Continuous flow microfluidic device for rapid erythrocyte lysis. Anal Chem Nov 1;76(21):6247-53, 2004.
  47. Chao, T.H., Lam, T., Vong, B.G., Traves, P.G., Hortelano, S., Chowdhury, C., Bahjat, F.R., Lloyd, G.K., Moldawer, L.L., Bosca, L., Palladino, M.A., Theodorakis, E.A. A New Family of Synthetic Diterpenes that Regulates Cytokine Synthesis by Inhibiting IkappaBalpha Phosphorylation. Chembiochem Nov 12, 2004.
  48. Feezor, R.J., Baker, H.V., Mindrinos, M., Hayden, D., Tannahill, C.L., Brownstein, B.H., Fay, A., MacMillan, S., Laramie, J., Xiao, W., Moldawer, L.L., Cobb, J.P., Laudanski, K., Miller-Graziano, C.L., Maier, R.V., Schoenfeld, D., Davis, R.W., Tompkins, R.G., and the Inflammation and Host Response to Injury Large Scale Collaborative Research Program. Whole Blood and Leukocyte RNA Isolation for Gene Expression Analyses. Physiological Genomics Nov;19:(3);247-54, 2004.
  49. Matsumoto, T., Efron, P.A., Tsujimoto, H., Tschoeke, S.K., Ungaro, R., Fujita, S., Foley, D.P., Hemming, A., Moldawer, L.L. Splenic transposition is superior to caudal shunt as a model of murine total hepatic ischemia. Lab Invest Nov 22; 2004.
  50. Oberholzer, C., Oberholzer, A., Tschoeke, S.K., Minter, R.M., Bahjat, F.R., LaFace, D., Hutchins, B., Moldawer, L.L. Influence of recombinant adenovirus on liver injury in endotoxicosis and its modulation by IL-10 expression.J Endotoxin Res 10(6):393-401, 2004.
  51. Tsujimoto, H., Ono, S., Majima, T., Kawarabayashi, N., Takayama, E., Kinoshita, M., Seki, S., Hiraide, H., Moldawer, L.L., Mochizuki, H. Neutrophil elastase, MIP-2, and TLR-4 expression during human and experimental sepsis. Shock Jan;23(1):39-44, 2004.
  52. Qian, W.J., Jacobs, J.M., Camp, D.G. 2nd, Monroe, M.E., Moore, R.J., Gritsenko, M.A., Calvano, S.E., Lowry, S.F., Xiao, W., Moldawer, L.L., Davis, R.W., Tompkins, R.G., Smith, R.D. Comparative proteome analyses of human plasma following in vivo lipopolysaccharide administration using multidimensional separations coupled with tandem mass spectrometry. Proteomics Feb;5(2):572-84, 2005.
  53. Tschoeke, S.K., Moldawer, L.L. Human leukocyte antigen expression in sepsis: what have we learned? Crit Care Med Jan;33(1):236-7,2005.
  54. Qian, W.J., Monroe, M.E., Liu, T., Jacobs, J.M., Anderson, G.A., Shen, Y., Moore, R.J., Anderson, D.J., Zhang, R., Calvano, S.E., Lowry, S.F., Xiao, W., Moldawer, L.L., Davis, R.W., Tompkins, R.G., Camp, D.G. 2nd, Smith, R.D. Quantitative proteome analysis of human plasma following in vivo lipopolysaccharide administration using 16O/18O labeling and the accurate mass and time tag approach. Mol Cell Proteomics 2005 Mar 7
  55. Cobb, J.P., Mindrinos, M.N., Miller-Graziano, C., Calvano, S.E., Baker, H.V., Xiao, W., Laudanski, K., Brownstein, B.H., Elson, C.M., Hayden, D.L., Herndon, D.N., Lowry, S.F., Maier, R.V., Schoenfeld, D.A., Moldawer, L.L., Davis, R.W., Tompkins, R.G., Baker, H.V., Bankey, P., Billiar, T., Brownstein, B.H., Calvano, S.E., Camp, D., Chaudry. I., Cobb, J.P., Davis, R.W., Elson, C.M., Freeman, B., Gamelli, R., Gibran, N., Harbrecht, B., Hayden, D.L., Heagy, W., Heimbach, D., Herndon, D.N., Horton, J., Hunt, J., Laudanski, K., Lederer, J., Lowry, S.F., Maier, R.V., Mannick, J., McKinley, B., Miller-Graziano, C., Mindrinos, M.N., Minei, J., Moldawer, L.L., Moore, E., Moore, F., Munford, R., Nathens, A., O'keefe, G., Purdue, G., Rahme, L., Remick, D., Sailors, M., Schoenfeld, D.A., Shapiro, M., Silver, G., Smith, R., Stephanopoulos, G., Stormo, G., Tompkins, R.G., Toner, M., Warren, S., West, M., Wolfe, S., Xiao, W., Young, V. Application of genome-wide expression analysis to human health and disease. Proc Natl Acad Sci U S A Mar 29;102(13):4801-6, 2005.
  56. Lainee, P., Efron, P., Tschoeke, S.K., Elies, L., De Winter, H., Lorre, K., Moldawer, L.L. Delayed neutralization of interferon-gamma prevents lethality in primate Gram-negative bacteremic shock. Crit Care Med Apr;33(4):797-805, 2005.
  57. Oberholzer, C., Tschoeke, S.K., Bahjat, K., LaFace. D., Hutchins, B., Clare-Salzler, M.J., Moldawer, L.L., Oberholzer, A. In vivo transduction of thymic dendritic cells with adenovirus and its potential use in acute inflammatory diseases. Scand J Immunol. 2005 Apr; 61(4):309-15.
  58. Oberholzer, A., Souza, S.M., Tschoeke, S.K., Oberholzer, C., Abouhamze, A., Pribble, J.P., Moldawer, L.L. Plasma cytokine measurements augment prognostic scores as indicators of outcome in patients with severe sepsis. Shock. 2005 Jun;23(6):488-93.
  59. Oberholzer, A., Oberholzer, C., Efron, P., Bahjat, K., Ungaro, R., Tannahill, C., Murday, M., Bahjat, F., Tsai, V., Hutchins, B., Moldawer, L.L., LaFace, D., Clare-Salzler, M. Functional modification of dendritic cells with recombinant adenovirus encoding IL-10 for the treatment of sepsis. Shock. 2005 Jun;23(6);507-15.
  60. Litherland, S.A., Xie, T.X., Grebe, K.M., Davoodi-Semiromi, A., Elf, J., Belkin, N.S., Moldawer, L.L., Clare-Salzer, M.J.Signal transduction activator of transcription 5 (STAT5) dysfunction in autoimmune monocytes and macrophages. J Autoimmun. 2005 Jun;24(4):297-310. Epub 2005 Mar 23.
  61. Efron, P.A., Tsujimoto, H., Bahjat, F.R., Ungaro, R., Debernardis, J., Tannahill, C., Baker, H.V., Edwards, C.K., Moldawer, L.L. Differential Maturation of Murine Bone-Marrow Derived Dendritic Cells with Lipopolysaccharide and Tumor Necrosis Factor-a. J Endotoxin Res. 2005;11(3):145-60.
  62. Biberthaler, P., Bogner, V., Baker, H.V., Lopez, M.C., Neth, P., Kanz, K., Mutschler, W., Jochum, M., Moldawer, L.L. Genome-wide monocytic mRNA Expression in Polytrauma Patients for Identification of Clinical Outcome. Shock. 2005 Jul;24(1):11-19.
  63. Tsujimoto, H., Uchida, T., Efron, P.A., Scumpia, P.O., Verma, A., Matsumoto, T., Tschoeke, S.K., Ungaro, R.F., Ono, S., Seki, S., Clare-Salzler, M.J., Baker, H.V., Mochizuki, H., Ramphal, R., Moldawer, L.L. Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactions. J Leukoc Biol. 2005 Jul 20;
  64. Scumpia, P.O., McAuliffe, P.F., O'malley, K.A., Ungaro, R., Uchida, T., Matsumoto, T., Remick, D.G., Clare-Salzler, M.J., Moldawer, L.L., Efron, P.A. CD11c+ Dendritic Cells Are Required for Survival in Murine Polymicrobial Sepsis. J Immunol. 2005 Sep 1;175(5):3282-6.
  65. Calvano, S.E., Xiao, W., Richards, D.R., Felciano, R.M., Baker, H.V., Cho, R.J., Chen, R.O., Brownstein, B.H., Cobb, J.P., Tschoeke, S.K., Miller-Graziano, C., Moldawer, L.L., Mindrinos, M.N., Davis, R.W., Tompkins, R.G., Lowry, S.F., Large Scale Collab Res Program IA. Abstract A network-based analysis of systemic inflammation in humans. Nature. 2005 August 31.
  66. De, A.K., Miller-Graziano, C.L., Calvano, S.E., Laudanski, K., Lowry, S.F., Moldawer, L.L., Remick, D.G. Jr., Rajicic, N., Schoenfeld, D., Tompkins, RG. Selective activation of peripheral blood T cell subsets by endotoxin infusion in healthy human subjects corresponds to differential chemokine activation. J Immunol. 2005 Nov 1;175(9):6155-62.
  67. Feezor, R.J., Cheng, A., Paddock, H.N., Baker, H.V., Moldawer, L.L. Functional genomics and gene expression profiling in sepsis: beyond class prediction. Clin Infect Dis. 2005 Nov 15;41 Suppl 7:S427-35.
  68. McAuliffe, P.F., Murday, M.E., Efron, P.A., Scumpia, P.O., Ungaro, R., Abouhamze, A., Tannahill, C.L., Hutchins, B., Laface, D., Moldawer, L.L. Dose-dependent improvements in outcome with adenoviral expression of interleukin-10 in a murine model of multisystem organ failure. Gene Ther. 2005 Oct 27.
  69. Schreiber, J., Efron, P.A., Park, J.E., Moldawer, L.L., Barbul, A. Adenoviral gene transfer of an NF-kappaB super-repressor increases collagen deposition in rodent cutaneous wound healing. Surgery. 2005 Nov;138(5):940-946.
  70. Calvano, S.E., Xiao, W., Richards, D.R., Felciano, R.M., Baker, H.V., Cho, R.J., Chen, R.O., Brownstein, B.H., Cobb, J.P., Tschoeke, S.K., Miller-Graziano, C., Moldawer, L.L., Mindrinos, M.N., Davis, R.W., Tompkins, R.G., Lowry, S.F., Bankey, P.E., Billiar, T.R., Camp, D.G., Casella, G., Chaudry, I.H., Choudhry, M.A., Cooper, C., De, A., Elson, C., Freeman, B., Gamelli, R.L., Campbell-Finnerty, C., Gibran, N.S., Hayden, D.L., Harbrecht, B.G., Herndon, D.N., Horton, J.W., Hubbard, W.J., Hunt, J.L., Johnson, J., Klein, M.B., Lederer, J.A., Logvinenko, T., Maier, R.V., Mannick, J.A., Mason, P.H., McKinley, B.A., Minei, J.P., Moore, E.E., Moore, F.A., Nathens, A.B., O'keefe, G.E., Rahme, L.G., Remick, D.G., Schoenfeld, D.A., Schwacha, M.G., Shapiro, M.B., Silver, G.M., Smith, R.D., Storey, J.D., Toner, M., Warren, H.S., West, M.A.. Corrigendum: A network-based analysis of systemic inflammation in humans. Nature. 2005 Dec 1;438(7068):696.
  71. Scumpia, P.O., Moldawer, L.L.. Biology of interleukin-10 and its regulatory roles in sepsis syndromes. Crit Care Med. 2005 Dec;33(12 Suppl):S468-S471.
  72. McAuliffe, P.F., Efron, P.A., Scumpia, P.O., Uchida, T., Mutschlecner, S.C., Rout, W.R., Moldawer, L.L., Cendan, J.C.. Varying blood monocyte and dendritic cell responses after laparoscopic versus open gastric bypass surgery. Obes Surg. 2005 Nov-Dec;15(10):1424-31.
  73. Moldawer, L.L.. WHAT'S NEW IN Shock, January 2006? Shock. 2006 Jan;25(1):1-3. 300) Marshall, J.C., Deitch, E., Moldawer, L.L., Opal, S., Redl, H., Poll, T.V.. PRECLINICAL MODELS OF SHOCK AND SEPSIS: WHAT CAN THEY TELL US? Shock. 2005 Dec;24 Suppl 1:1-6.
  74. Delano, M.J., Moldawer, L.L., The origins of cachexia in acute and chronic inflammatory diseases. Nutr Clin Pract. 2006 Feb;21(1):68-81.
  75. Oberholzer, C., Tschoeke, S.K., Moldawer, L.L., Oberholzer, A. Local thymic caspase-9 inhibition improves survival during polymicrobial sepsis in mice. J Mol Med. 2006 Feb 2;:1-7.
  76. Tsujimoto, H., Ono, S., Majima, T., Efron, P.A., Kinoshita, M., Hiraide, H., Moldawer, L.L., Mochizuki, H., Differential toll-like receptor expression after ex vivo lipopolysaccharide exposure in patients with sepsis and following surgical stress. Clin Immunol. 2006 Mar 3.
  77. Tschoeke, S.K., Oberholzer, A., Moldawer, L.L., Interleukin-18: A novel prognostic cytokine in bacteria-induced sepsis. Crit Care Med. 2006 Apr.
  78. Mathur, A., Baz, M., Staples, E.D., Bonnell, M., Speckman, J.M., Hess, P.J. Jr, Klodell, C.T., Knauf, D.G., Moldawer, L.L., Beaver, T.M.. Cytokine profile after lung transplantation: correlation with allograft injury. Ann Thorac Surg. 2006 May;81(5):1844-50.
  79. Liu, T., Qian, W.J., Gritsenko, M.A., Xiao, W., Moldawer, L.L., Kaushal, A., Monroe, M.E., Vamum, S.M., Moore, R.J., Purvine, S.O., Maier, R.V., Davis, R.W., Tompkins, R.G., Camp, D.G. 2nd, Smith, R.D. High dynamic range characterization of the trauma patient plasma proteome. Mol Cell Proteomics. 2006 Jun 8.
  80. Moldawer, L.L. What's new in shock, june 2006? Shock. 2006 Jun;25(6):555-6.
  81. Moore, F.A., McKinley, B.A., Moore, E.E., Nathens, A.B., West, M., Shapiro, M.B., Bankey, P., Freeman, B., Harbrecht, B.G., Johnson, J.L., Minei, J.P., Maier, R.V. Inflammation and the Host Response to Injury, a Large-Scale Collaborative Project: Patient-Oriented Research Core-Standard Operating Procedures for Clinical Care: III. Guidelines for Shock Resuscitation. J Trauma. 2006 Jul;61(1):82-89.
  82. Moldawer, L.L. What's new in shock, August 2006. Shock. 2006 Aug;26(2):111-4.
  83. Sethu, P., Moldawer, L.L., Mindrinos, M.N., Scumpia, P.O., Tannahill, C.L., Wilhelmy, J., Efron, P.A., Brownstein, B.H., Tompkins, R.G., Toner, M. Microfluidic isolation of leukocytes from whole blood for phenotype and gene expression analysis. Anal Chem. 78(15):5453-61. Aug 1, 2006.
  84. Edwards, C.K. 3rd, Bendele, A.M., Reznikov, L.I., Fantuzzi, G., Chlipala, E.S., Li, L., Moldawer, L.L., Mountz, J.D., Li, Y.Y., Dinarello, C.A. Soluble human p55 and p75 tumor necrosis factor receptors reverse spontaneous arthritis in transgenic mice expressing transmembrane tumor necrosis factor alpha. Arthritis Rheum. 2006 Aug 31;54(9):2872-2885.
  85. O'malley, K., Moldawer, L.L. Interleukin-6: Still crazy after all these years. Crit Care Med. 2006 Oct;34(10):2690-1.
  86. Tsujimoto, H., Efron, P.A., Matsumoto, T., Ungaro, R.F., Abouhamze, A., Ono, S., Mochizuki, H., Moldawer, L.L. Maturation of murine bone marrow-derived dendritic cells with poly(I:C) produces altered TLR-9 expression and response to CpG DNA. Immunol Lett. 2006 Sep 22.
  87. Tsujimoto, H., Ono, S., Matsumoto, A., Kawabata, T., Kinoshita, M., Majima, T., Hiraki, S., Seki, S., Moldawer, L.L., Mochizuki, H. A critical role of CpG motifs in a murine peritonitis model by their binding to highly expressed toll-like receptor-9 on liver NKT cells. J Hepatol. 2006 Sep 22;
  88. Laudanski, K., Miller-Graziano, C., Xiao, W., Mindrinos, M.N., Richards, D.R., De, A., Moldawer, L.L., Maier, R.V., Bankey, P., Baker, H.V., Brownstein, B.H., Cobb, J.P., Calvano, S.E., Davis, R.W., Tompkins, R.G. Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15564-9. Epub 2006 Oct 10.
  89. Matsumoto, T., O'Malley, K., Efron, P.A., Burger, C., McAuliffe, P.F., Scumpia, P.O., Uchida, T., Tschoeke, S.K., Fujita, S., Moldawer, L.L., Hemming, A.W., Foley, D.P. Interleukin-6 and STAT3 protect the liver from hepatic ischemia and reperfusion injury during ischemic preconditioning. Surgery. 2006 Nov;140(5):793-802.
  90. Scumpia, P.O., Delano, M.J., Kelly, K.M., O'malley, K.A., Efron, P.A., McAuliffe, P.F., Brusko, T., Ungaro, R., Barker, T., Wynn, J.L., Atkinson, M.A., Reeves, W.H., Clare Salzler, M.J., Moldawer, L.L. Increased Natural CD4+CD25+ Regulatory T Cells and Their Suppressor Activity Do Not Contribute to Mortality in Murine Polymicrobial Sepsis. J Immunol. 2006 Dec 1;177(11):7943-9.

 
Biosketch
Education
1986Ph.D. (Dr. Med. Sci.), University of Gothenberg,Gothenburg, Sweden, in Experimental Medicine
 
Academic Appointments
2004- presentVice Chairman of Research, University of Florida, College of Medicine, Gainesville, Florida
1996 - presentProfessor of Surgery, University of Florida College of Medicine, Gainesville, Florida
1994 - 1996Associate Professor of Surgery (with tenure)University of Florida College of Medicine,Gainesville, Florida
1993 - 1996Associate Professor of Surgery, University of Florida College of Medicine, Gainesville, Florida
1991 - 1993Associate Professor of Cell Biology and Anatomy,Cornell University Medical College, New York, New York.
1991 - 1993Associate Professor of Surgery, Cornell University Medical College, New York, New York.
1988 - 1991Assistant Professor of Cell Biology and Anatomy,Cornell University Medical College, New York, New York.
1987 - 1991Assistant Professor of Surgery,Cornell University Medical College, New York, New York.
1985 - 1987Visiting Scientist, Department of Surgery I, Sahlgrenska sjukhuset,S-41345 Goteborg, Sweden.

 
Links
  1. Inflammation and the Host Response to Injury (http://www.gluegrant.org/index.htm)
    Dr. Moldawer is Co-Director of the Protein Analysis and Cell Biology Core, and a member of the Steering Committee, of a National Institute of General Medical Sciences Large Scale Collaborative Research Program (Glue Grant) entitled, “Inflammation and the Host Response to Injury”, funded through 2006 to introduce functional genomics and high throughput proteomics into trauma and sepsis research.

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