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Surgical Laboratory of Hepatobiliary and Pancreatic Pathobiology |
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The Surgical Laboratory of Hepatobiliary and Pancreatic Pathobiology is interested in the role of chronic inflammation in the regulation of liver and pancreatic cell growth control. The chronically inflamed liver and pancreas are susceptible to neoplastic changes, and the mechanisms that regulate these changes are of interest to us. Our laboratory focuses on cell signaling and apoptosis related to chronic inflammation. We are particularly interested in the role transforming growth factor beta (TGFb) plays in chronic inflammation and cell signaling because this cytokine is up-regulated in these circumstances and often induces apoptosis. Using animal models of chronic liver and pancreatic inflammation, we are examining the mechanisms by which chronic inflammation may lead to resistance to apoptosis and thereby promote malignant transformation. Our NIH-funded laboratory, located
the Medical Sciences Building, collaborates with numerous other basic and
translational science groups within the Department of Surgery and basic science
departments. Our mission is to foster basic and translational science
investigation of the mechanisms of cell growth regulation in the chronically
inflamed liver and pancreas. This brief overview defines our interest and
if you would like further information please contact us.
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