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Alex Cuenca, M.D.
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Alex G. Cuenca is a PGY-3 general surgery resident at
the University of Florida. He will spend three years in the lab of
Dr. Moldawer and be the 4th general surgery resident at UF to
matriculate in the PhD program. Additionally, he is a trainee in the
T32 Research Fellowship in Trauma and Burns in the Laboratory of
Inflammation Biology and Surgical Science. His two areas of research
focus will be in neonatal sepsis and sepsis in cancer patients. He
plans to pursue a career in academic pediatric or vascular surgery
upon completion of general surgery training. HONORS / AWARDS T32 NRSA Research Fellow (2008-2011) Arnold P Gold Humanism Honor Award (2006) Edward R Woodward Surgical Award (2006) Employee of the year Honorable Mention (2000) H Lee Moffitt Cancer and Research Institute National Institute of Aging Supplemental Award sponsored by Dr. Robert A Good For under represented minorities in research (1999) New College Foundation Grant (1996) PUBLICATIONS 1) AG. Cuenca, Alexandra Wiggins, Mike K. Chen, David W. Kays, Saleem Islam, Elizabeth A. Beierle. Equestrian Injuries in Children. (In Press Journal of Pediatric Surgery 2009) 2) Cuenca AG and Beierle EA. Pulmonary Surgery in Cystic Fibrosis. Seminars in Pediatric Surgery 2008 Feb 17 (1): 60-5 3) Cuenca AG, Jiang H, Hochwald SN, Delano M, Cance WG, Grobmyer SR. Emerging implications of nanotechnology on cancer diagnostics and therapeutics. Cancer 2006 Aug 1: 107 (3) 459-66 Review 4) Horna P, Cuenca A, Cheng F, Brayer J, Wang HW, Borrello I, Levitsky H, Sotomayor EM. In vivo disruption of tolerogenic cross-presentation mechanisms uncovers an effective T-cell activation by B-cell lymphomas leading to antitumor immunity. Blood. 2006 Apr 1;107(7):2871-8. Epub 2005 Dec 8 5) H Wang, F Cheng, A Cuenca, P Horna, Z Zheng, K Bhalla, EM Sotomayor. Imatinib mesylate (STI-571) enhances antigen-presenting cell function and overcomes tumor induced CD 4+ T-cell tolerance. Blood 2005 105 (3): 1135-43 6) AG Cuenca, Fengdong Cheng, Lingping Gu, Harold Bien, Ivan M Borrello, Hyam I Levitsky, and Eduardo M Sotomayor. Extra-lymphatic solid tumor growth is not immunologically ignored and results in early induction of antigen-specific t cell anergy: dominant role of “ Cross tolerance” to tumor antigens. Cancer Res. 2003 Dec 15;63(24):9007-15 7) F Cheng, A Cuenca, H Yu, R Jove, and EM Sotomayor. A Critical Role for STAT-3 signaling in immune tolerance. Immunity. 2003 Sep;19(3):425-36 8) AG Cuenca, W Douglass Cress, Robert A Good, Yasmin Marikar, Robert W Engelman. Calorie Restriction Influences Cell Cycle Protein Expression and DNA Synthesis during Liver Regeneration. Exp Biol Med (Maywood). 2001 Dec;226(11):1061-7. 9) EM Sotomayor, I Borrello, F Rattis, AG Cuenca, J Abrams, K Stanley-Ocarroll, and HI Levitsky. Cross presentation of tumor antigens by bon e marrow derived antigen presenting cells is the dominant mechanism in the induction of T cell tolerance during B cell lymphoma progression. Blood 2001 98 (4): 1070-1077 ABSTRACTS AND CONFERENCE PRESENTATIONS 1) AG Cuenca, A Ali, MK Chen, DW. Kays , EA Beierle, and S Islam. “Pulling the plug”-Management of Meconium Plug Syndrome in neonates. 4th Annual Academic Surgical Congress 2009 2) AG Cuenca, F Cheng, H Wang, I Trindade, HI Levitsky, and EM Sotomayor. Tolerogenic Antigen Presenting Cells (APCs) represents a critical barrier for T cell adoptive immunotherapy of B cell malignancies. Oral Presentation. 43rd annual meeting of the American Society of Hematology 2001. 3) AG Cuenca, F Cheng, H Wang, J Green, WS Dalton, and EM Sotomayor. Modulation of antigen presenting cell (APC) function by aminobisphosphonates enhances T cell priming and prevents tumor induced T cell tolerance. 43rd annual meeting of the American Society of Hematology 2001. 4) F Cheng, AG Cuenca, H Wang, M huang, K H Shain, R Jove, H Yu, EM Sotomayor. Inihibition of JAK STAT3 Signaling in B cell lymphomas enhances antigen presentation and restores responsiveness of T cells from tumor bearing hosts: implications for immunotherapy of B cell malignacies. . 43rd annual meeting of the American Society of Hematology 2001. 5) F Cheng, AG Cuenca, H Wang, JP Allison, I Borrelo, HI Levitsky, and EM Sotomayor. In vitro blockade of CTLA-4 enhances the priming of Naïve T cells and Restores the Responsiveness of T cells from lymphoma bearing hosts: Implications for T cell adoptive immunotherapy of B cell malignacies. . 43rd annual meeting of the American Society of Hematology 2001. 6) H Wang, F Cheng, AG Cuenca, K Bhalla, and EM Sotomayor. STI-571, a selective tyrosine kinase inhibitor, significantly enhances antigen presentation by bone marrow derived APCs: Implications for immunotherapy of tumor derived from antigen presenting cells. . 43rd annual meeting of the American Society of Hematology 2001. 7) T Pyhel, G Tan, KA Noonan, AG Cuenca, EM Sotomayor, HI Levitsky, I Borrello. Autologous bone marrow transplantation delays lymphoma induced T cell tolerance and restores responsiveness of T cells from tumor bearing mice: evidence of an autologous graft vs Lymphoma Effect. . 43rd annual meeting of the American Society of Hematology 2001. 8) AG Cuenca and F Cheng. Novel strategies to break tumor-induced antigen specific tolerance. Oral presentation. Research in Progress Seminar H Lee Moffitt Cancer and Research Center 2001. 9) F Cheng, AG Cuenca, L Burdelya, M Huang, R Jove, H Yu, EM Sotomayor. Inhibition of STAT signaling by JAK-Kinase selective inhibitor tryphostin AG490 enhances antigen presentation function in vitro and in vivo. 42rd annual meeting of the American Society of Hematology 2000. 10) Alex G Cuenca, W Douglass Cress, Robert A Good, Yasmin Marikar, Robert W Engelman. Calorie Restriction Influences Cell Cycle Protein Expression and DNA Synthesis during Liver Regeneration. American Association of Cancer Research 2000. |
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