Tad Kim, M.D.  

 

Honors:                                                                                                          1. 2009 Society of Teaching Scholars Outstanding Resident Teacher Award                                                                                         2. 2009 STS Scholarship for Aspiring Cardiothoracic Surgeons               3. 2006 Ray-Bierstedt memorial Award for Outstanding Surgery Intern    4. 2004 Gold Humanism Honor Society

Research Projects and Interests:
PGY 4 Categorical Surgery Resident and Research Fellow in the Thoracic and Cardiovascular Surgery Research Laboratory under the direction of Dr. Curtis G. Tribble and Dr. Charles E. Hobson, in the Department of Surgery, Division of Thoracic and Cardiovascular Surgery, at the University of Florida. At present, Dr. Kim’s research interest is in postoperative acute kidney injury. Current projects include validating the “isolated perfused rat kidney” model - a versatile tool for studying an organ in isolation - and studying ischemia-reperfusion injury using this model. The ultimate goal is to perform high through-put testing of compounds that may provide renal protection from ischemia-reperfusion injury. This isolated organ model will also be complemented by in-vivo renal artery clamp-and-release studies.

In addition, we are currently in phase 2 clinical trials to test a new compound, AP214, which may attenuate the inflammatory response associated with kidney injury in cardiopulmonary bypass patients.

Current Bench Projects:
1. To validate the isolated perfused rat kidney (IPRK) model
2. To validate a gadolinium-based marker for GFR determination using immunoassay techniques.
3. To model ischemia-reperfusion injury in the IPRK and in-vivo rat kidney
4. To test compounds (i.e. atrial natriuretic peptide, AP214, rasburicase) for renal protective effect against ischemia-reperfusion injury.

Clinical Projects:
1. Phase II randomized clinical trial on a novel drug, AP 214, believed to attenuate the inflammatory response associated with acute kidney injury.
2. Retrospective analysis of the evolution in our management of extensive thoracic aortic aneurysms: comparison of single stage transmediastinal replacement of the total thoracic aorta versus elephant trunk repair with open completion versus elephant trunk repair with endovascular completion.
3. Retrospective analysis of correlation between early biomarker profiles and organ injury & resource utilization in complex cardiac surgery patients.
4. Retrospective review of our institutional experience in esophagectomies.

Bibliography:

Peer-reviewed Publications:

1. Kim T, Arnaoutakis GJ, Bihorac A, Martin TD, Hess PJ Jr, Klodell CT, Tribble CG, Moldawer LL, Ejaz AA, Beaver TM. Early blood biomarkers predict organ injury and resource utilization following complex cardiac surgery. pending
(oral presentation in the Surgical Forum at the American College of Surgeons’ 94th Annual Clinical Congress 2008)

2. Ejaz AA, Beaver TM, Shimada M, Sood P, Lingegowda V, Schold J, Kim T, Johnson RJ. Uric acid is a novel risk factor for acute kidney injury in high-risk cardiac surgery patients. pending

3. Kim T, Martin TD, Lee WA, Hess PJ, Klodell CT, Tribble CG, Feezor RJ, Beaver TM. Evolution in the management of the total thoracic aorta. Journal of Thoracic and Cardiovascular Surgery 2009;137:627-34. (oral presentation at the 34th Annual Meeting of the Western Thoracic Surgical Association 2008) (poster presentation at the University of Florida Department of Surgery Research Day, April 18, 2008)

4. Kim T, Grobmyer SR, Dixon LR, Allan RW, Hochwald SN. Autoimmune pancreatitis and concurrent small lymphocytic lymphoma : not just a coincidence? Journal of Gastrointestinal Surgery 2008;12:1566-70.

5. Kim T, Grobmyer SR, Dixon LR, Hochwald SN. Isolated lymphoplasmacytic sclerosing pancreatitis involving the pancreatic tail. The American Surgeon 2008;74:654-8.
(poster presentation at the 2008 Annual Scientific Meeting of the Southeastern Surgical Congress)

6. Kim T, Grobmyer SR, Liu C, Hochwald SN. Primary presacral neuroendocrine tumor associated with imperforate anus. World Journal of Surgical Oncology 2007;5:115.

7. Hill JM, Morisawa G, Kim T, Huang T, Wei Y, Wei YF, Werner MH. Identification of an expanded binding surface on the FADD death domain responsible for interaction with CD95/Fas. Journal of Biological Chemistry 2004;279:1474-1481.

8. Gray MC, Donato GM, Jones FR, Kim T, Hewlett EL. Newly Secreted Adenylate Cyclase Toxin is Responsible for Intoxication of Target Cells by Bordatella pertussis. Molecular Microbiology 2004;53:1709-1719.

Non Peer-Reviewed Publications:

1. Wilson JP, Kim T, Yamaguchi DJ, Lee CW. Trauma Resident Manual. University of Florida, Department of Surgery, Division of Acute Care Surgery. pending

2. ICU Recall, 3rd edition, 2008. (Chapter contributor)




 

 

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