Primate Studies in Sepsis Research
Efron PA, Tinsley K, Minnich DJ, Monterroso V, Wagner J, Lainee P, Lorre K, Swanson PE, Hotchkiss R, Moldawer LL. Increased lymphoid tissue apoptosis in baboons with bacteremic shock. Shock . 2004 Jun;21(6):566-71. Rosenberg, J.J., Martin, S.W., Seely, J.E., Kinstler, O., Gaines, G.C., Fukuzuka, K., Rose, J., Kohno, T., Boyle, W.J., Nelson, A., Kieft, G.L., Marshall, W.S., Feige, U., Gasser, J., St. Clair, J., Frazier, J., Moldawer, L.L., Edwards, III, C.K. Development of a novel non-immunogenic soluble human TNF receptor type I (sTNF-RI) construct in the baboon. J. Appl. Physiology 91(5):2213-2223, 2001. Solorzano, C.C., Kaibara, A., Hess, P.J., Edwards, P.D., Ksontini, R.,
Abouhamze, A., McDaniel, S., Frazier, J., Trujillo, D., Kieft, G.,
Seely, J., Kohno, T., Cosenza, M.E., Clare-Salzler, M., MacKay, S.L.D.,
Martin, S.W., Moldawer , L.L., Edwards, C.K. 3rd. Pharmacokinetics,
immunogenicity, and efficacy of dimeric TNFR binding proteins in
healthy and bacteremic baboon.
Journal of Applied Physiology, 84(4):1119-1130, 1998 |
The Laboratory of Inflammation Biology and Surgical Science,
in collaboration with the Department of
Comparative Medicine, undertake sepsis research in primates,
particularly in the baboon (Papio sp.). These studies employ Gram negative and
Gram positive models of septic shock and systemic inflammatory
response syndromes. Resources are available to maintain and monitor
animals in a critical care setting with invasive hemodynamic
monitoring and support. Industrial collaborations, including the
development of protein- and gene-based therapies have demonstrated the
cost-effectiveness of these models for the exploration of
pharmacokinetics, pharmacodynamics, antigenicity, acute, sub-acute and
chronic toxicities in the development of new therapies for the
treatment of septic patients.