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Research Interests
Robert Winfield is currently a PGY-5 General Surgery Resident. He
recently completed two years as a trainee in the T32 Research
Fellowship in Trauma and Burns in the Laboratory of Inflammation
Biology and Surgical Science and is working primarily under the
guidance of Dr. Lyle L. Moldawer. He maintains active research into
dysfunctional inflammatory responses of obese patients to injury and
post-injury resuscitation. Other interests include trauma and burn
prevention. He plans to pursue a career in academic pediatric or
acute care surgery (trauma surgery, emergency surgery, and surgical
critical care) upon completion of general surgery training.
Honors and Distinctions
2008 University of Florida Department of Surgery Research Day – Best
Clinical Abstract Award
2008 Eastern Association for the Surgery of Trauma - Templeton
Injury Prevention Award Finalist
2003 Alpha Omega Alpha Honor Medical Society
2003 American Association for the Surgery of Trauma Medical Student
Scholarship
Publications/Chapters
Wynn JL, Scumpia PO, Winfield RD, Delano MJ, Barker T, Ungaro RF,
Levy O, Moldawer LL. “Defective innate immunity predisposes murine
neonates to poor sepsis outcome, but is reversed by TLR agonists.”
Blood. 2008 Jun 30. [Epub ahead of print].
Winfield RD, Chen MK, Langham MR, Kays DW, Beierle EA. “Ashes,
Embers, and Coals: Significant Sources of Burn-Related Morbidity in
Children”. Journal of Burn Care and Research. 2008
January/February;29(1):109-113.
Winfield RD, Ang DN, Chen MK, Kays DW, Langham MR Jr, Beierle EA.
The use of Seprafilm in pediatric surgical patients. The American
Surgeon. 2007 Aug;73(8):792-5.
Scumpia PO, Delano MJ, Kelly-Scumpia KM, Weinstein JS, Wynn JL, Xia
C, Winfield RD, Chung CS, Ayala A, Heyworth PG, Reeves WH, Clare-Salzer
MJ, Moldawer LL. “Treatment with GITR agonistic antibody corrects
adaptive immune dysfunction and improves survival in murine sepsis”.
Blood. 2007 Nov 15;110(10):3673-81.
Winfield RD, Hochwald SN, Vogel SB, Hemming AW, Liu C, Cance WG,
Grobmyer SR. “Presentation and Management of Duodenal
Gastrointestinal Stromal Tumors”. The American Surgeon. 2006
Aug;72(8):719-22; discussion 722-3.
Winfield RD, Beierle EA. “Pediatric Surgical Issues in Meconium
Disease and Cystic Fibrosis”. Surgical Clinics of North America.
2006 Apr; 86(2): 317-21
Winfield RD, Moldawer LL. “Gene Therapy in Critical Illness: Past
Applications and Future Potential”. Civetta, Taylor, and Kirby –
Critical Care, 4th Edition. In Press.
Winfield RD, Lottenberg L. “The Secondary and Tertiary Survey in
Acute Trauma”. Civetta, Taylor, and Kirby – Critical Care, 4th
Edition. In Press.
Winfield RD, Parr AG, Ang DN, Martin TD, Chen MK, Seagle MB,
Hochwald SN, Reed AI, Lottenberg L. “An Intensive Board Review
Course: A Spectacular Case of Dual Impalement in Vehicular Trauma”.
The American Surgeon. In Press.
Winfield RD, Delano MJ, Scumpia PO, Moldawer LL. “Myeloid Derived
Suppressor Cells in Cancer Cachexia: A New Explanation for an Old
Problem”. Journal of Parenteral and Enteral Nutrition. In Press.
Winfield RD; Delano MJ; Dixon DJ; Schierding WS; Cendan JC;
Lottenberg L; Hayden D; Lopez MC; Baker HV; Cobb JP; Moldawer LL;
Maier RV; Cuschieri J. “Differences in Outcome between Obese and
Non-Obese Patients Following Severe Blunt Trauma are Not Consistent
with an Early Inflammatory Genomic Response”. Submitted for
publication in the Journal of Critical Care Medicine.
Delano MJ, Scumpia PO, Kelly-Scumpia KM, Winfield RD, Wynn JL,
Moldawer LL. “Splenic Myeloid Derived Suppressor Cell Expansion
Dependence on CXCL12 Signaling During Sepsis.” Poster presentation
June 28, 2008 at the International Shock Society Annual Meeting,
Cologne, Germany.
Winfield RD, Delano MJ, Dixon D, Schierding W, Leek JT, Cendan JC,
Hayden D, Lopez MC, Baker HV, Cobb JP, Moldawer LL, Maier RV,
Cuschieri J. “Initial Genomic Response does not Predict Outcome
Between Obese and Normal Weight Patients Following Severe Blunt
Trauma.” Poster presentation May 13, 2008 at the 7th Annual
Colloquium of the International Sepsis Forum, Chapel Hill, NC.
Winfield RD, Delano MJ, Lottenberg L, Cendan JC, Moldawer LL, Maier
RV, Cuschieri J. “Early Resuscitative Practices Fail to Correct
Metabolic Acidosis in Morbidly Obese Trauma Patients.” Oral
presentation April 18, 2008 at the University of Florida Department
of Surgery Research Day, Gainesville, FL. Winner, Best Clinical
Abstract award.
Winfield RD, Delano MJ, Moldawer LL. “The Role of Myeloid Derived
Suppressor Cells in Cancer Cachexia.” Poster presentation April 18,
2008 at the University of Florida Department of Surgery Research
Day, Gainesville, FL.
Islam SK, Winfield RD, Vick L, McVay M. “Traumatic Pancreatic
Injuries in Children.” Poster presentation at the 2008 Meeting of
the British Association of Paediatric Surgeons, Edinborough,
Scotland, United Kingdom.
Winfield RD, Parr AG, Ang DN, Burch PT, Chen MK, Reed AI, Hochwald
SN, Martin TD, Lottenberg L. “An Intensive Board Review Course: A
Spectacular Case of Dual Impalement in Vehicular Trauma”. Poster
presentation February 11, 2008 at the 2008 Annual Meeting of the
Southeastern Surgical Congress, Birmingham, AL.
Wilson JP, Burgess G, Winfield RD, Lottenberg L. “Sturgeons versus
Surgeons: Leaping Fish Injuries at a Level I Trauma Center”. Poster
presentation February 11, 2008 at the 2008 Annual Meeting of the
Southeastern Surgical Congress, Birmingham, AL.
Winfield RD, Mozingo DW, Armstrong JH, Hollenbeck JI, Richards WT,
Martin L, Lottenberg L. “Preventing All-Terrain Vehicle Trauma: Is
Legislation Really the Answer?”. Oral presentation January 17, 2008
at the Annual Meeting of the Eastern Association for the Surgery of
Trauma, Jacksonville, FL. 2008 John Templeton Injury Prevention
Award finalist.
Winfield RD, Moldawer LL, Scumpia PO, Wynn JL, Delano MJ, O'Malley
KA, Moreno CO, Cance WG, Beierle EA. “Focal Adhesion Kinase in
Necrotizing Enterocolitis”. Poster presentation October 27, 2007 in
the Surgical Section at the 2007 Annual Meeting of the American
Academy of Pediatrics, San Francisco, CA.
Winfield RD, Macaulay C, Moldawer LL. “TPV-2L Demonstrates Potent in
Vitro Anti-TNF- Activity”. Poster presentation October 11, 2007 at
the 2007 Annual Meeting of the Society for Leukocyte Biology,
Cambridge, MA.
Winfield RD, Chen MK, Langham MR, Kays DW, Beierle EA. “Ashes,
Embers, and Coals: Significant Sources of Burn-Related Morbidity in
Children”. Poster presentation April 20, 2007 at the 2007 University
of Florida Department of Surgery Research Day, Gainesville, FL.
Winfield RD, Chen MK, Langham MR, Kays DW, Beierle EA. “Ashes,
Embers, and Coals: Significant Sources of Burn-Related Morbidity in
Children”. Poster presentation March 21, 2007 at the Annual Meeting
of the American Burn Association, San Diego, CA.
Winfield RD, Wynn JL, O’Malley KA, Ungaro RF, Trujillo A, Cance WG,
Beierle EA, Moldawer LL. “Focal Adhesion Kinase Expression and
Activation in Intestinal Inflammation”. Oral poster presentation
March 13, 2007 at the 7th World Congress on Trauma, Shock,
Inflammation, and Sepsis, Munich, Germany.
Wynn JL, Scumpia PO, Winfield RD, Delano MJ, O’Malley KA, Ungaro R,
Abouhamze A, Moldawer LL. “Improved Survival in Neonatal Mice with
Sepsis Following TLR Agonist Treatment”. Poster presentation March
15, 2007 at the 7th World Congress on Trauma, Shock, Inflammation,
and Sepsis, Munich, Germany.
Delano MJ, Scumpia PO, O’Malley KA, Wynn J, Winfield RD, Moldawer
LL. “Sepsis Reprograms Bone Marrow Hematopoiesis Toward The Myeloid
Lineage In A MyD88 And TRIF Dependent Manner”. Oral presentation
March 13, 2007 at the 7th World Congress on Trauma, Shock,
Inflammation, and Sepsis, Munich, Germany.
Winfield RD, Ang DN, Langham MR, Chen MK, Kays DW, Beierle EA. “The
Use of Hyaluronate Carboxymethylcellulose (Seprafilm) in a Pediatric
Population: A Retrospective Review”. Poster presentation February
11, 2007 at the Annual Meeting of the Southeastern Surgical
Congress, Savannah, GA.
Winfield RD, Hochwald SN, Vogel SB, Hemming AW, Liu C, Cance WG,
Grobmyer SR. “Importance of Tumor Site in the Presentation and
Management of Gastrointestinal Stromal Tumors”. Oral Presentation
May 26, 2006 at the Annual Meeting of the Florida Chapter of the
American College of Surgeons, Boca Grande, FL.
Winfield RD, Hochwald SN, Vogel SB, Hemming AW, Liu C, Cance WG,
Grobmyer SR. “Presentation and Management of Gastrointestinal
Stromal Tumors of the Duodenum”. Poster Presentation March 31, 2006
at the 2006 University of Florida Department of Surgery Research
Day, Gainesville, FL.
Winfield RD, Hochwald SN, Vogel SB, Hemming AW, Liu C, Cance WG,
Grobmyer SR. “Presentation and Management of Gastrointestinal
Stromal Tumors of the Duodenum”. Oral Presentation February 19, 2006
at the Annual Meeting of the Southeastern Surgical Congress, Lake
Buena Vista, FL.
Submitted/Pending Abstracts and Publications
Winfield RD, Delano MJ, Cuschieri J, Dixon D, Schierding W, Cendan
JC, Baker HV, Maier RV, Cobb JP, Moldawer LL. “Initial Genomic
Response Does Not Predict Differences in Outcome Between Obese and
Normal Weight Patients Following Severe Blunt Trauma”. Accepted for
poster presentation at the 2008 Annual Meeting of the American
Association for the Surgery of Trauma.
Delano MJ, Scumpia PO, Weinstein JS, Kelly-Scumpia KM, O’Malley KA,
Wynn JL, Winfield RD, Moreno CO, Ramphal R, Gabrilovich DI, Reeves
WH, Clare-Salzler M, Moldawer LL. “IL-4, IL-10, and CCR2 Signaling
Do Not Contribute to the Increased Myeloid Derived Suppressor Cell
Numbers or Function During Polymicrobial Sepsis”. Submitted for
publication in The Journal of Leukocyte Biology.
Delano MJ, Scumpia PO, Wynn JL, Moreno CO, O’Malley KA, Winfield RD,
Moldawer LL. “Myeloid-Derived Suppressor Cells and their
Contribution to Post-Injury and Sepsis Immune Suppression”.
Submitted for publication in Blood.
Wilson JP, Burgess G, Winfield RD, Lottenberg L. “Sturgeons versus
Surgeons: Leaping Fish Injuries at a Level I Trauma Center”.
Submitted for publication in The American Surgeon.
Winfield RD, Delano MJ, Lottenberg L, Cendan JC, Moldawer LL, Maier
RV, Cuschieri J. “Traditional Resuscitative Practices Fail to
Resolve Metabolic Acidosis in Morbidly Obese Patients Following
Severe Blunt Trauma”. Submitted for presentation at the 2009 Annual
Meeting of the Eastern Association for the Surgery of Trauma.
Islam SK, Winfield RD, Vick L, McVay M. “Traumatic Pancreatic
Injuries in Children.” Manuscript in preparation for publication in
the Journal of Pediatric Surgery.
Invited Presentations/Discussions
Invited Speaker 2008 University of Florida Graduate Seminars in
Physiological Sciences: “Clinical, Genomic, and Physiologic
Responses of the Obese Patient to Severe Traumatic Injury”
Invited Speaker 2007 Shands at the University of Florida Trauma
Multidisciplinary Conference: “ATV-related Injuries: Is Legislation
Really the Answer?”
Invited Speaker 2007 University of Florida Department of Surgery
Grand Rounds: “Obesity and Critical Illness: Clinical and Genomic
Features”
Invited Speaker 2007 Shands at the University of Florida Trauma
Tracks Trauma Nurse Education Series: “Traumatic Shock”
Invited Speaker 2007 Shands at the University of Florida Trauma
Resuscitation Nurse Course: “Advanced Procedures”
Invited Speaker 2007 Shands at the University of Florida Trauma
Awareness Day: “Burns to Little Feet are a BIG Problem!”
Invited Speaker 2007 American Association of Critical Care Nurses,
North Central Florida Chapter, Annual Meeting: “Pediatric Trauma:
Beyond the Band-Aid”
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