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Amer S. Abouhamze, M.H.A.
Senior Biological Scientist
University of Florida
Department of Surgery
P.O. Box 100286
1600 SW Archer Road, Room 6116
Gainesville, Florida 32610-0286
Telephone: (352) 265-0494
FAX: (352) 265-0676
Email: Amer@surgery.ufl.edu
Education:
M.H.A., 2004
University of Florida
Gainesville, Florida
B.S., 1997
University of Florida
Gainesville, Florida
Professional Experience:
Student Assistant
University of Florida Department of Surgery/ VA Medical Center
Surgical Metabolism and Nutrition Laboratories
Wiley W. Souba, M.D., ScD., Director
Gainesville, Florida 1991-1993
Biological Scientist
University of Florida Department of Surgery
Department of Surgery Research Laboratories
Lyle L. Moldawer, Ph.D., Director
Gainesville, Florida
1994-1997
Senior Biological Scientist
University of Florida Department of Surgery
Laboratory of Inflammation Biology and Surgical Science
Lyle L. Moldawer, Ph.D., Director
Gainesville, Florida
1997-Present
Publications:
1) Sarantos-P; Abouhamze-A; Souba-WW. Glucocorticoids regulate
intestinal glutaminase expression.
Surgery 1992 Aug; 112(2): 278-283
2) Sarantos-P; Abouhamze-A; Chakrabarti-R; Souba-WW. Glucocorticoids
regulate intestinal
glutamine synthetase gene expression in endotoxemia. Arch-Surg. 1994
Jan; 129(1): 59-65
3) Sarantos-P; Abouhamze-A; Abcouwer-S; Chakrabarti-R; Copeland-EM;
Souba-WW. Cytokines decrease glutaminase expression in human
fibroblasts. Surgery 1994 Aug; 116(2): 276-83
4) Espat-NJ; Auffenberg-T; Abouhamze-A; Baumhofer-J; Moldawer-LL;
Howard-RJ; A role for tumor necrosis factor-alpha in the increased
mortality associated with Vibrio vulnificus infection in the
presence of hepatic dysfunction. Ann Surg 1996 Apr; 223(4): 428-33
5) Welborn, M.B., Douglas, W.G., Abouhamze, Z., Auffenburg, T.,
Abouhamze, A.S., Baumhofer, J., Seeger, J.M., Pruitt, J.H., Edwards,
P.D., Chizzonite, R., Martin, D., Moldawer , L.L., Harward, T.R.S.
Visceral ischemia-reperfusion injury promotes tumor necrosis factor
(TNF) and interleukin-1 (IL-1) dependent organ injury in the mouse.
Shock 6(3) 171-176, 1996.
6) Solorzano, C.C., Pruitt, J.H., Ksontini, R., Auffenberg, T.,
Abouhamze, A., Hess, P.J., Edwards, P.D., Tannahill, C., Galardy,
R.E., Schultz, G.P., MacKay, S.L.D., Copeland, E.M., Moldawer , L.L.
A matrix metalloproteinase inhibitor prevents processing of TNFα and
abrogates endotoxin-induced lethality. Shock, 7;427-431, 1997.
7) Solorzano, C.C., Ksontini, R., Pruitt, J.H., Hess, P.J., Edwards,
P.D., Kaibara, A ., Abouhamze,A., Auffenberg, T., Galardy, R.E.,
Vauthey,J.N., Copeland, E.M., III., Edwards, C.K., III., Lauwers,
G.Y., Clare-Salzler, M., MacKay, S.L.D., Moldawer, L.L. and Lazarus,
D.D. Involvement of 26 kD cell-associated TNF in experimental
hepatitis and exacerbation of liver injury with a
matrix-metalloproteinase inhibitor. Journal of Immunology, 158:
414-419, 1997.
8) Deak, T., Meriwether, J.L., Fleshner, M., Spencer, R.L.,
Abouhamze, A., Moldawer , L.L., Grahn, R.E., Watkins, L.R., Maier,
S.F. Evidence that brief stress may induce the acute phase response
in rats. American Journal Physiology, 42:R1998-R-2004, 1997.
9) Solorzano, C.C., Kaibara, A., Hess, P.J., Edwards, P.D., Ksontini,
R., Abouhamze, A., McDaniel, S., Frazier, J., Trujillo, D., Kieft,
G., Seely, J., Kohno, T., Cosenza, M.E., Clare-Salzler, M., MacKay,
S.L.D., Martin, S.W., Moldawer , L.L., Edwards, C.K. 3rd.
Pharmacokinetics, immunogenicity, and efficacy of dimeric TNFR
binding proteins in healthy and bacteremic baboon. Journal of
Applied Physiology, 84(4):1119-1130, 1998.
10) Thornton, F.J., Shaffer, M.R., Witte, M.B., Moldawer , L.L.,
MacKay, S.L., Abouhamze, A., Tannahill, C.L., Barbul, A. Enhanced
collagen accumulation following direct transfection of the inducible
nitric oxide synthase gene in cutaneous wounds. Biochemical
Biophysical Research Communications, 246(3):654-659, 1998.
11) Kaibara, A., Moshyedi, A., Auffenberg, T., Abouhamze, A.,
Copeland, E.M. 3rd, Kalra, S., Moldawer , L.L. Leptin produces
anorexia and weight loss without inducing an acute phase response or
protein wasting. American Journal of Physiology, 274(6 pt
2):R1518-R1525, 1998.
12) Kaibara, A., Espat, N.J., Auffenberg, T., Abouhamze, A.S.,
Martin, D., Kalra, S., Moldawer , L.L. Interleukin 6, but not
ciliary neurotrophic factor or leukaemia inhibitory factor, is
responsible for the acute phase response to turpentine-induced
myositis. Cytokine, 10(6):452-456, 1998.
13) Denham, W., Yang, J., MacKay, S., Tannahil,l C., Carter, G.,
Abouhamze, A., Moldawer , L.L., Norman, J. Cationic
liposome-mediated gene transfer during acute pancreatitis: tissue
specificity, duration, and effects of acute inflammation. J
Gastrointest Surg, 2(1):95-101, 1998.
14) Josephs, M.D., Solorzano, C.C., Taylor, M., Rosenberg, J.J.,
Topping, D., Abouhamze, A., MacKay, S.L.D., Hirsch, E., Hirsh, D.,
LaBow, M, Moldawer , L.L. Modulation of the acute phase response to
a turpentine abscess by altered expression of the IL-1 p80 receptor
or IL-1 receptor antagonist. Am J Physiol 278:R824-30; 2000.
15) Norman, J., Denham, W., Denham, D., Yang, J., Carter, G.,
Abouhamze, A., Tannahill, C.L., MacKay,S.L.D., Moldawer , L.L.
Liposome-mediated, nonviral gene transfer induces a systemic
inflammatory response which can exacerbate pre-existing
inflammation. Gene Therapy, 7:1425-30, 2000.
16) Lee, R.H., Efron, D.T., Tantry, U., Stuelten, C., Moldawer,
L.L., Abouhamze, A., Barbul, A.. Inhibition of tumor necrosis
factor-alpha attenuates wound breaking strength in rats. Wound
Repair Regen 8(6):547-553, 2000.
17) Oberholzer, C., Oberholzer, A., Bahjat, F.R., Minter, R.M.,
Tannahill, C.L., Abouhamze , A., LaFace, D., Hutchins, B.,
Clare-Salzler, M.J., Moldawer, L.L. Targeted adenovirus-induced
expression of IL- 10 decreases thymic apoptosis and improves
survival in murine sepsis. Proc. Natl. Acad. Sci. 98(20):11503-8,
2001.
19) Schell S.R., Wessels F.J., Abouhamze A., Moldawer L.L., Copeland
E.M. 3rd. Pro- and antiinflammatory cytokine production after
radiofrequency ablation of unresectable hepatic tumors. J Am Coll
Surg 195(6):774-81, 2002.
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