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Thomas M.
Beaver
M.D. |
RESEARCH INTERESTS:
Dr. Beaver's research interests focus on improving the care of patients undergoing both thoracic aortic and cardiac surgery. Ongoing clinical trials are studying novel surgical techniques to treat atrial fibrillation and stent grafting for thoracic aortic aneurysms. Improved surgical treatments for heart failure are also being investigated. Dr. Beaver is the principal surgical investigator at The University of Florida for the NIH sponsored STICH trial, which has been evaluating the SVR (surgical ventricular restoration) procedure and coronary artery bypass surgery for heart failure. Additional clinical trials are evaluating newer pharmacologic agents to improve postoperative care by reducing pulmonary hypertension and renal failure.
In collaboration with Dr. Lyle Moldawers' laboratory, Dr. Beaver has been characterizing the cytokine cascade that occurs following lung transplantation. Dr. Beaver's own laboratory employs an optical mapping system developed with Dr. William Ditto, Chief of Biomedical Engineering at The University of Florida. Ongoing projects are investigating the interaction between atrial electrical wave fronts and the ablation lines created by the novel energy sources that have been introduced to treat atrial fibrillation.
PUBLICATIONS:
1. Beaver TM, Fullerton DA, Zamora MR: Colon perforation after lung transplantation. Ann Thorac Surg 1996; 62:839-43.
2. Beaver TM, Martin TD Single stage trans-mediastinal replacement of the ascending, arch and descending thoracic aorta Ann Thorac Surg 2001;72:1232-8.
3. Beaver TM, "New energy sources revolutionize atrial fibrillation surgery," Physicians Practice 2003;13(6):A5.
4. Bonnel M, Urdanetta F, Kirby DS, Valdez N, Beaver TM, Lobato EB Effects of sildenafil analogue UK 343-664 on a porcine model of acute pulmonary hypertension. Ann Thorac Surg 2004 77(1):238-42.
5. Bonnel M, Visner GA, Zander DS, Mandalapu S, Kazemfar K, Spears L,
Beaver TM Heme-oxygenase-1 expression correlates with severity of Acute cellular rejection in lung transplantation. J Am Coll Surg 2004;198:945-952.
6. Urdanetta F, Willert JL, Beaver TM, Naik B, Kirby DS, Lobato AB Effects of a new phosphodiesterase enzyme type V inhibitor (UK 343-664) versus milrinone on a porcine model of acute pulmonary hypertension. (Accepted, Ann Thorac
Surg).
7. Trachte, A, Lobato EB, Urdanetta F, Klodell CT, HessPJ, Staples ED, Martin TD,
Beaver TM, Oral sildenafil reduces pulmonary hypertension after cardiac surgery (Accepted, Ann Thorac
Surg).
8. Amit Mathur, Maher Baz MD, Mark Staples MD, Phillip Hess MD, Charles Klodell MD, Dan Knauf MD, LL Moldawer MD,
Thomas M Beaver, MD Cytokine Profile following Lung Transplantation: Correlation with Reperfusion Injury. (In preparation)
9. Beaver TM, Jennifer Simmonoto, Michael Furman, Aris Miliotis, Anupadmaja Raghavan, William Ditto Optical Imaging of Atrial Ablation Lines.(In preparation).
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