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Elizabeth A.
Beierle
M.D. |
RESEARCH INTERESTS:
Dr. Beierle's primary focus in the laboratory is the study of cell survival signals in neuroblastoma. Neuroblastoma is a pediatric solid tumor of neural crest origin. This tumor is unique in its biologic behavior, in that, when it presents in infants the primary tumor and even metastasis will often spontaneously regresses and disappears with limited therapy. However, older children presenting with metastatic disease have a dismal prognosis. Dr. Beierle would like to elucidate the mechanisms that are responsible for this behavior. Her laboratory has been investigating a number of survival signals and pathways including VEGF, IGF, Bcl-2, survivin, AKT and FAK.
PUBLICATIONS:
1. Beierle EA, Nicolette LA, Billmire DF, Vinocur CD, Weintraub WH, Dunn SP. Gastrointestinal perforation after pediatric orthotopic liver transplantation. J Pediatr Surg 33:240-242, 1998.
2. Chen MK, Strande L, Beierle EA, Kain M, Geldziler B, Doolin EJ. Fas-mediated induction of hepatocyte apoptosis in a neuroblastoma and hepatocyte coculture model. J Surg Res, 84:82-87, 1999.
3. Beierle EA, Chen MK, Whalen TV, Doolin EJ. Free fluid on abdominal CT after blunt trauma does not mandate exploratory laparotomy in children. J Pediatr Surg 35:990-994, 2000.
4. Beierle EA, Strande LF, Geldziler BD, Chen MK. Neuroblastoma and hepatocyte coculture conditioned media alter apoptosis. J Surg Res 90:113-118, 2000.
5. Beierle EA, Strande LF, Berger, AC, Chen MK. VEGF is upregulated in a neuroblastoma and hepatocyte co-culture model. J Surg Res 97:34-40, 2001.
6. Beierle EA, Strande LF, Chen MK. VEGF upregulates Bcl-2 expression in neuroblastoma and is protective against apoptotic stimuli. J Pediatr Surg, 37:467-471, 2002.
7. Beierle EA, Strande LF, Chen MK. Insulin-like growth factor-I protects neuroblastoma from apoptosis. J Pediatr Surg, 37:472-476, 2002.
8. Beierle EA, Dai W, Copeland EM, Langham MR, Chen MK. Caspase 3 expression is altered in a coculture model of neuroblastoma. J Surg Res 106:323-327, 2002.
9. Beierle EA, Dai W, Langham MR, Chen MK. Neuroblastoma: apoptosis and growth factors. Am Surg 69:28-31, 2003.
10. Beierle EA, Dai W, Langham MR, Copeland EM, Chen MK. VEGF receptors are differentially expressed by neuroblastoma in coculture. J Pediatr Surg 38:514-521, 2003.
11. Beierle EA, Dai W, Iyengar R, Langham MR, Copeland EM, Chen MK. Differential expression of Bcl-2 and Bax may enhance neuroblastoma survival. J Pediatr Surg 38:486-491, 2003.
12. Paddock HN, Schultz GS, Varela JC, Baker HV, Beierle EA, Moldawer LL, Mozingo DW. Differential gene expression in human post-burn hypertrophic scars compared to normal skin. J Burn Care Rehab 6:371-377, 2003.
13. Burry MV, Reig AS, Beierle E, Chen M, Mericle RA: Extracorporeal Membrane Oxygenation combined with endovascular embolization for management of neonatal high output cardiac failure secondary to intracranial arteriovenous fistula. J Neurosurg (Pediatrics 2) 100:197-200, 2004.
14. Chen MK, Beierle EA. Animal models for intestinal tissue engineering. Biomaterials 9:1675-1681, 2004.
15. Beierle EA, Dai W, Langham MR, Copeland EM, Chen MK: Expression of VEGF receptors in cocultured neuroblastoma cells. J Surg Res 119:56-65, 2004.
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