Pediatric Surgery
 
Mike Kuang-Sing Chen M.D.

RESEARCH INTERESTS:

Dr. Chen's current research interest is in tissue engineering.  He is interested in enhancing the understanding of tissue regeneration and in particular, the ability for creating neointestine. He has used biomaterials as a scaffold in animal models to regenerate neointestine.  Patients with short bowel syndrome do not have adequate absorption capacity and transplantation is the best therapy.  Problems include graft rejection, graft vs. host problems, and inadequate donor supply. Tissue engineered bowel may offer a better solution.


PUBLICATIONS:

1. Badylak SF, Meurling S, Chen M, Spievack A, Simmons-Byrd A:  Resorbable bioscaffold for esophageal repair in a dog model.  J Pediatr Surg 35:1097-1103, 2000.


2. Albaugh G, Chen MK:  Adrenal adenocarcinoma in two female children.  Ped Surg Int 17:71-74, 2001.


3. Chen MK and Badylak SF:  Small bowel tissue engineering using small intestinal submucosa as a scaffold.  J Surg Res 99:352-358, 2001.


4. Faro A, DeNicola LK, Beierle EA, Langham MR, Kissoon N, Pham N, Hendeles
L, Kays DW, Chen MK. Extracorporeal membrane oxygenation rescue therapy in a child with status asthmaticus: limits of conventional therapy. J Pediatr Pharmacol Ther 6:504-508, 2001.


5. Chen MK and Beierle EA:  Gastrointestinal foreign bodies.  Pediatr Ann 12:736-742, 2001.


6. Beierle EA, Chen MK, Langham MR, Kays DW, Talbert JL.  Small watercraft injuries in children.  Am Surg, 68:535-538, 2002.


7. Beierle EA, Dai W, Langham MR, Chen MK:  Neuroblastoma: apoptosis and growth factors.  Am Surg, 69:28-31, 2003.


8. Langham MR, Kays DW, Beierle EA, Chen MK, Mullet TC, Rieger K, Wood CE, Talbert JL. Twenty years of progress in congenital diaphragmatic hernia at the University of Florida.  Am Surg, 69:45-52, 2003.


9. Langham MR, Kays DW, Beierle EA, Chen MK, Stringfellow K, Talbert JL. Expanded application of extracorporeal membrane oxygenation in a pediatric surgery practice.  Ann Surg, 237:766-774, 2003.


10. Chen MK, Beierle EA:  Animal models for intestinal tissue engineering.  Biomaterials, 25:1675-1681, 2004.

11. Burry MV, Reig AS, Beierle E, Chen M, Mericle RA.  Extracorporeal
Membrane Oxygenation combined with endovascular embolization for management of neonatal high output cardiac failure secondary to intracranial arteriovenous fistula. J Neurosurg 100(2 suppl):197-200, 2004.


12. Beierle EA, Chen MK, Hartwich JE, Iyengar M, Dai W, Li N, DeMarco VG, Neu J.  Artificial rearing of mouse pups: development of a mouse pup in a cup model.  Pediatr Res, 56(2):250-255, 2004


13. Paddock H, Beierle EA, Chen MK, Mullett T, Wood CM, Kays DW, Langham MR Jr.  Administration of prenatal betamethasone suppresses the adrenal-hypophyseal axis in newborns with congenital diaphragmatic hernia.  J Pediatr Surg, 39:1176-1182, 2004


14.  Neu J, Chen MK, Beierle EA.  Intestinal innate immunity: how does it relate to the pathogenesis of necrotizing enterocolitis?  Semin Pediatr Surg, 14:137-144, 2005.
 

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