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RESEARCH INTERESTS:
PGY 5 Categorical Surgery
Resident and T32 Research Fellow
in the
Laboratory of Inflammation Biology
and Surgical Science under the direction of Dr. Lyle L.
Moldawer, in the
Department of Surgery at the University of Florida.
Dr. Delano is also perusing a doctoral degree with a concentration
in Immunology, in the Department of Immunology and Microbiology
through the Interdisciplinary Program in Biomedical Sciences at the
University of Florida. After finishing his qualifying exam, entitled
Impact of Immature Myeloid Cells in Sepsis in the fall of
2006, Dr. Delano is now on track to defend his thesis in the spring
of 2008. His research
interest before coming to the University of Florida focused on the
role of chemokine signaling in pancreatic cancer metastasis while
working in the Ronald Hirshberg Translational Pancreatic Cancer
Laboratory under the direction of Dr. Howard Reber, at The David
Geffen School of Medicine at UCLA. At present, Dr. Delano's
research interests have shifted focus to concentrate on the immune
responses that occur during sepsis. His current projects include
investigating the interactions of T lymphocytes, dendritic cells,
and immature myeloid cells and their role in the development and
propagation of the sepsis syndrome. In addition he is also
investigating the human inflammatory reaction to trauma, sepsis, and
cardiopulmonary bypass by evaluating the genomic, proteomic, and
cellular immune phenotypes that result from these various insults.
CURRENT PROJECTS:
1.)
To determine the role that T regulatory lymphocytes play in
the development and propagation of the sepsis syndrome.
2.)
To investigate novel immature myeloid cell populations that
have immune modulatory effects during the sepsis syndrome.
3.)
To investigate the immunomodulatory effects that sepsis has
on the host immune system and how those effects can be ameliorated
with various therapeutic interventions.
4.)
To determine the human genomic and proteomic responses to
cardiopulmonary bypass and elucidate the elements that mediate
systemic inflammation.
5.)
To use the prospectively collected data compiled by the
Inflammation and the Host Response to Injury
collaborative research program and determine what genomic and
proteomic elements predispose trauma patients to a poor outcome.
AWARDS:
FINALIST: A.E. BAUE RESEARCH AWARD.
Selected as one of the top 10 abstracts out of over 500 abstracts at
the 7th World Congress on Trauma, Shock, Inflammation and Sepsis.
M.J. Delano, P.O. Scumpia, K. O'Malley, J. Wynn, and L.
Moldawer. Sepsis Reprograms Bone Marrow Hematopoiesis Toward The
Myeloid Lineage In A MyD88 And TRIF Dependent Manner. Accepted
Abstract and Oral Presentation. 7th World Congress on Trauma, Shock,
Inflammation and Sepsis - TSIS 2007, March 13-17, 2007, Munich,
Germany.
RECIPIENT: CLINICAL/TRANSLATIONAL SCIENCE RESEARCH AWARD.
M.J. Delano, G.M. Janelle, P.O. Scumpia, K. O'Malley, R.
Ungaro, C.L. Tannahill, E.D. Staples, T. Martin, L.L. Moldawer, and
P.J. Hess. Aprotinin Attenuates The Immuno-inflammatory Response And
Alters Blood Monocyte Gene Expression Following Cardiopulmonary
Bypass. Award Received: April 20, 2007, Department of General
Surgery, University of Florida School of Medicine, Gainesville, FL.
RECIPIENT: THE DR. HERMAN BROWN AWARD FOR EXCELLENCE IN THE STUDY
OF THE ART AND SCIENCE OF SURGERY. Awarded for excellence in
both patient care and surgical research. Award Received: May 22,
2003, Temple University School of Medicine, Department of General
Surgery.
RECIPIENT: ASSOCIATION OF ACADEMIC SURGERY 2003 STUDENT RESEARCH
AWARD.
Delano MJ, Duffy JP, Fisher C, Hines OJ, Reber HA: Cellular and
Molecular Expression of CXCR4 in Human Pancreatic Cancer Cell Lines:
Department of Surgery, The David Geffen School of Medicine at the
University of California, Los Angeles, CA. Abstract Accepted: March
28, 2003, Association of Academic Surgery 2003 Student Research
Award
RECIPIENT: 2003 TEMPLE UNIVERSITY SCHOOL OF MEDICINE STUDENT
RESEARCH DAY AWARD
Delano MJ, Duffy JP, Fisher C, Hines OJ, Reber HA: Cellular
and Molecular Expression of CXCR4 in Human Pancreatic Cancer Cell
Lines: Department of Surgery, The David Geffen School of Medicine at
the University of California, Los Angeles, CA; Department of
Surgery, Temple University School of Medicine, Philadelphia, PA.
Oral Poster Presentation: April 16, 2003, Temple University School
of Medicine Student Research Award 2003
NOMINATED: ASSOCIATION OF ACADEMIC SURGERY 2002 MEDICAL STUDENT
RESEARCH AWARD.
Delano MJ, Duffy JP, Hines OJ, Reber HA: The role of CXCR4
and SDF-1 in pancreatic cancer invasion and metastasis: Department
of Surgery, The David Geffen School of Medicine at the University of
California, Los Angeles, CA
Submitted: March 29, 2002, Association of Academic Surgery 2002
Student Research Award.
BIBLIOGRAPHY:
Publications
1. Delano MJ, Janelle GM, Scumpia PO, O'Malley K, Ungaro R,
Tannahill CL, Staples ED, Martin T, Moldawer LL, Hess PJ. The Effect
of Aprotinin on the Immuno-inflammatory Response and Blood Monocyte
Gene Expression in Response to Cardiopulmonary Bypass. (Manuscript
in Preparation) 2007
2. James L. Wynn, Philip O. Scumpia, Robert D. Winfield, Matthew
J. Delano, Tolga Barker, Minoru Satoh, Ricardo Ungaro, Ofer
Levy, Lyle L. Moldawer. Defects in Innate Immunity Predispose
Neonates To Poor Outcome From Sepsis, But Can Be Overcome By Select
Toll Like Receptor Agonists. (Submitted Manuscript: Nature Medicine)
2007
3. Delano MJ, Hochwald SN, Garces CA, Cance WG, Grobmyer SR.
Preoperative Predictors of Intraoperative Blood Transfusion
Requirement for Patients Undergoing Pancreaticoduodenectomy.
(Manuscript in Preparation) 2007
4. Matthew J. Delano, Philip O. Scumpia, Jason S. Weinstein,
Kindra M. Kelly-Scumpia, Kerri A. O'Malley, James Wynn, Robert D.
Winfield, Claudia Moreno, Reuben Ramphal, Wesley H. Reeves, Michael
Clare-Salzler, Lyle L. Moldawer. IL-4, IL-10 and CCR2 Signaling Do
Not Contribute to the Increased Myeloid Derived Suppressor Cell
Numbers or Function During Polymicrobial Sepsis. (Invited
Manuscript) 2007
5. Matthew J. Delano, Philip O. Scumpia, James L. Wynn, Kerri
O'Malley, Claudia Moreno, Robert D. Winfield, Lyle L. Moldawer.
Myeloid-Derived Suppressor Cells and their Contribution to
Post-Injury and Sepsis Immune Suppression. (Invited Manuscript) 2007
6. Scumpia PO, Delano MJ, Kelly-Scumpia KM, Weinstein JS,
Wynn JL, Winfield RD, Xia C, Chung CS, Ayala A, Atkinson MA, Reeves
WH, Clare-Salzler MJ, Moldawer LL. Treatment with GITR agonistic
antibody corrects adaptive immune dysfunction in sepsis. Blood. 2007
Aug 9; [Epub ahead of print]
7. Wynn JL, Scumpia PO, Delano MJ, O'Malley KA, Ungaro R,
Abouhamze A, Moldawer LL. Increased Mortality and Altered Immunity
in Neonatal Sepsis Produced by Generalized Peritonitis. Shock. 2007
Jul 5; [Epub ahead of print]
8. Delano MJ, Scumpia PO, Weinstein JS, Coco D, Nagaraj S,
Kelly-Scumpia KM, O'Malley KA, Wynn JL, Antonenko S, Al-Quran SZ,
Swan R, Chung CS, Atkinson MA, Ramphal R, Gabrilovich DI, Reeves WH,
Ayala A, Phillips J, Laface D, Heyworth PG, Clare-Salzler M,
Moldawer LL. MyD88-Dependent Expansion of an Immature GR-1+CD11b+
Population Induces T-Cell Suppression and TH2 Polarization in
Polymicrobial Sepsis. J Exp Med. 2007 Jun 11; 204(6):1463-74. Epub
2007 Jun 4
9. Iwakuma, N., Sharma, P., Delano, M.J., Moldawer, L.,
Moudgil, B., Grobmyer, S.R. Differential Uptake of PEG-FITC Silica
Nanoparticles by Human Breast Cancer Cells and Normal Human Breast
Epithelial Cells. NSTI Proceedings 2:348-349, 2007.
10. Scumpia PO, Delano MJ, Kelly KM, O'Malley KA, Efron PA,
McAuliffe PF, Brusko T, Ungaro R, Barker T, Wynn JL, Atkinson MA,
Reeves WH, Clare-Salzler MJ, Moldawer LL. Increased natural
regulatory T cells and their suppressor activity does not influence
mortality in murine polymicrobial sepsis. Journal of Immunol 2006
Dec 1; 177(11)
11. Cuenca AG, Jiang H, Hochwald SN, Delano M, Cance WG,
Grobmyer SR. Emerging Implications of Nanotechnology on Cancer
Diagnostics and Therapeutics. Cancer. 2006 Aug 1;107(3):459-66
12. Delano MJ, Moldawer LL. The Origins of Cachexia in Acute
and Chronic Inflammatory Diseases. Nutr Clin Pract. 2006
Feb;21(1):68-81
13. Dempsey DT, Delano M, Bradley K, Kolff J, Fisher C,
Caroline D, Gaughan J, Meilahn JE, Daly JM. Laparoscopic
esophagomyotomy for achalasia: does anterior hemifundoplication
affect clinical outcome? Annals of Surgery. June 2004; 239:6
14. Duffy JP, Delano MJ, Reber HA: Pancreatic Surgery.
Current Opinion in Gastroenterology: 2002; 18:568-573.
Published Abstracts
1. M.J. Delano, G.M. Janelle, P.O. Scumpia, K. O'Malley, R.
Ungaro, C.L. Tannahill, E.D. Staples, T. Martin, L.L. Moldawer, and
P.J. Hess. Aprotinin Attenuates The Immuno-inflammatory Response And
Alters Blood Monocyte Gene Expression Following Cardiopulmonary
Bypass. Surgery Research Symposium, Award Received: April 20, 2007,
Department of General Surgery, University of Florida School of
Medicine, Gainesville, FL.
2. MJ Delano M.D; CA Garces MD; WG Cance MD; SN Hochwald MD;
SR Grobmyer MD. Preoperative Predictors of Intraoperative Blood
Transfusion Requirement for Patients undergoing
Pancreaticoduodenectomy. Accepted Abstract and Poster Presentation,
AHPBA Annual Meeting, April 19-22, 2007.
3. Steven N. Hochwald, Stephen R. Grobmyer, Eleanor Curran,
Matthew Delano, Alan W. Hemming, William G. Cance, Stephen B.
Vogel. Braun enteroenterostomy is associated with reduced delayed
gastric emptying and early resumption of oral feeding following
pancreaticoduodenectomy. Accepted Abstract and Poster Presentation,
AHPBA Annual Meeting, April 19-22, 2007.
4. Delano, M.J., Scumpia, P.O., O'Malley, K., Wynn, J.,
Winfield, R. and Moldawer, L.L. Sepsis Reprograms Bone Marrow
Hematopoesis Toward The Myeloid Linage In A MyD88 And TRIF Dependent
Manner. Accepted Abstract and Oral Presentation. 7th World Congress
on Trauma, Shock, Inflammation and Sepsis - TSIS 2007, March 13-17,
2007, Munich, Germany.
5. Wynn, JL, Scumpia, PO, Winfield, RD, Delano, MJ, O'Malley,
K, Ungaro, R, Abouhamze, A, Moldawer, LL. Improved Survival in
Neonatal Mice with Sepsis Following TLR Agonist Treatment. Accepted
Abstract and Oral Presentation. 7th World Congress on Trauma, Shock,
Inflammation and Sepsis - TSIS 2007, March 13-17, 2007, Munich,
Germany.
6. Scumpia PO, Delano MJ, Kelly KM, Weinstein JS, Clare
Salzler MJ, Moldawer LL. Treatment with anti-GITR agonistic antibody
corrects T cell dysfunction and improves survival in murine sepsis.
Accepted Abstract and Oral Presentation. 7th World Congress on
Trauma, Shock, Inflammation and Sepsis - TSIS 2007, March 13-17,
2007, Munich, Germany.
7. MJ Delano M.D; CA Garces MD; WG Cance MD; SN Hochwald MD;
SR Grobmyer MD. Preoperative Predictors of Intraoperative Blood
Transfusion Requirement for Patients undergoing
Pancreaticoduodenectomy. Accepted Abstract and Poster Presentation,
AHPBA Annual Meeting, April 19-22, 2007.
8. Matthew J. Delano, M.D., Philip O. Scumpia, B.S., Ricardo
Ungaro, B.S., Cynthia L. Tannahill, M.S., Kerri O' Malley, Ph.D.,
Gregory M. Janelle, M.D., Amer Abouhamze, M.S., Thomas D. Martin,
M.D., Edward D. Staples, M.D., Walter W. Scott, M.D., Lyle L.
Moldawer, Ph.D., Philip J. Hess, M.D. Genomic and Proteomic
Responses after Cardiopulmonary Bypass Indicate Innate Immune System
Dysfunction. Accepted Abstract and Oral Presentation Society of
Thoracic Surgeons Annual Meeting San Diego, CA. January 28-30, 2007.
9. Azra Bihorac, Matthew Delano, Andrea Gabrielli, Avery B.
Nathens, Ronald V. Maier, A. Joseph Layon, and Lyle L Moldawer.
Incidence, clinical predictors, and outcome of acute kidney injury
among trauma patients. Accepted Abstract and Poster Presentation,
American Society of Nephrology 39th Annual Meeting and Scientific
Exposition, November 14-19, 2006. San Diego, CA.
10. Matthew J. Delano, M.D., Azra Bihorac, M.D., Philip O.
Scumpia, B.S., Avery B, Nathens, M.D., Ronald G. Maier, M.D., Joseoh
A. Layon, M.D., Lyle L. Moldawer, Ph.D. Early Genomic and Proteomic
Changes in Trauma Patients With Acute Kidney Injury Suggest Early
Immune Dysfunction. Accepted Abstract and Poster Presentation,
Innate Immunity Meeting, SLB, ISER, San Antonio, TX. November 9-11,
2006.
11. Qizhi Zhang, Ph.D., Matthew Delano, M.D., Huabei Jiang,
Ph.D., Stephen R. Grobmyer, M.D. Gold Nanoparticles as a Contrast
Agent for High Resolution in Vivo Imaging Using Photoacoustic
Tomography. Accepted Abstract and Oral Presentation, International
Nanoparticle Congress, San Francisco, CA. November 1-3, 2006.
12. MJ Delano, PO Scumpia, K O'Malley, J Wynn, R Ungaro, C
Tannahill, L Lottenberg, LL Moldawer. Immature Myeloid Cell Activity
in a Murine Polymicrobial Sepsis Model. Accepted Abstract and Poster
Presentation, AAST Meeting, New Orleans, LA September 28-30, 2006.
13. M. Delano, P. Scumpia, K. O'Malley, J. Wynn, R. Ungaro,
L. Moldawer. Regulation of GR-1+CD11b+ Myeloid Suppressor Cells in
Murine Polymicrobial Sepsis. Shock 2006 June (25)1:64. Supplement.
14. Scumpia PO, Delano MJ, Moldawer LL. Regulatory T cells
are increased but do not participate in mortality in murine
polymicrobial sepsis. Shock 2006 June (25)1:8. Supplement.
15. Scumpia PO, Weinstein JS, Delano MJ, Kelly KM, Reeves WH,
Clare-Salzler MJ, Moldawer LL. B cell dysfunction in sepsis is T
cell dependent. Leuk Biol Supplement (accepted).
16. M. Delano, P. Scumpia, K. O'Malley, J. Wynn, R. Ungaro,
C. Tannahill, A. Abouhamze, L. Moldawer. Regulation of GR-1+CD11b+
Myeloid Suppressor Cells in Murine Polymicrobial Sepsis. Oral
Presentation: Department of Surgery Research Day, University of
Florida, March 31, 2006.
17. Daniel T. Dempsey, M.D., Matthew Delano, M.D., Kevin
Bradley, M.D., Jeffrey Kolff, M.D., Carol Fisher, B.A., Dina
Caroline, M.D.*, John Gaughan, Ph.D.#, John E. Meilahn, M.D., John
M. Daly, M.D.: Laparoscopic esophagomyotomy for achalasia: does
anterior hemifundoplication affect clinical outcome?: Departments of
Surgery, Radiology*, and Biostatistics#, Temple University School of
Medicine, Philadelphia, PA. Abstract Presented: Southern Surgical
Association Meeting, December, 2003, Hot Springs, VA.
18. Delano MJ, Duffy JP, Fisher C, Hines OJ, Reber HA:
Cellular and Molecular Expression of CXCR4 in Human Pancreatic
Cancer Cell Lines: Department of Surgery, The David Geffen School of
Medicine at the University of California, Los Angeles, CA. Abstract
and Poster Presentation: March 28, 2003, Association of Academic
Surgery 2003 Student Research Award (AWARD RECIPIENT).
19. Delano MJ, Duffy JP, Fisher C, Hines OJ, Reber HA:
Cellular and Molecular Expression of CXCR4 in Human Pancreatic
Cancer Cell Lines: Department of Surgery, The David Geffen School of
Medicine at the University of California, Los Angeles, CA;
Department of Surgery, Temple University School of Medicine,
Philadelphia, PA. Abstract and Poster Presentation: April 16, 2003,
Temple University School of Medicine Research Day 2003 (AWARD
RECIPIENT).
20. JP Duffy, HA Reber, MN Wente, G Eibl, Y Okada, M Delano,
OJ Hines: Vitronectin stimulates mitogen-activated protein kinase
activity in human pancreatic cancer cells: Department of Surgery,
The David Geffen School of Medicine at the University of California,
Los Angeles, CA. Poster Presentation: 6th Annual Longmire Surgical
Society Scientific Day, UCLA, March 22, 2002.
21. Eibl G, Okada Y, Reber HA, Duffy J, Delano M, Wente MN,
Hines OJ: Prostaglandin E2 is mitogenic and increases VEGF in human
pancreatic cancer cells: Department of Surgery, The David Geffen
School of Medicine at the University of California, Los Angeles, CA.
Abstract Accepted: American College of Surgeons 88th Annual Clinical
Congress, San Francisco, CA, October 6-10, 2002.
22. Eibl G, Okada Y, Reber HA, Duffy J, Delano M, Wente MN,
Hines OJ: PPAR-γ stimulates plasminogen activator inhibitor-1 and
decreases urokinase-type plasminogen activator levels in human
pancreatic cancer cells: Department of Surgery, The David Geffen
School of Medicine at the University of California, Los Angeles, CA.
Oral Presentation Accepted: Association of Academic Surgery 36th
Annual Meeting, Boston, MA, November 7-9, 2002.
23. Duffy J, Eibl G, Okada Y, Delano M, Reber H, Hines J:
Vitronectin stimulates p44/42 mitogen-activated protein kinase in
human pancreatic cancer cells: Department of Surgery, The David
Geffen School of Medicine at the University of California, Los
Angeles, CA. Oral Poster Presentation Abstract Accepted: Association
of Academic Surgery 36th Annual Meeting, Boston, MA, November 7-9,
2002.
24. John P. Duffy, Howard A. Reber, Guido Eibl, Yuji Okada, Moritz
N. Wente, Matthew J. Delano, Oscar J. Hines: Evidence for
vitronectin autocrine regulation in pancreatic cancer cells.
Department of Surgery, The David Geffen School of Medicine at the
University of California, Los Angeles, CA. Abstract and Poster
Presentation Accepted: American Pancreatic Association Annual
Meeting, November 14-15, 2002.
25. Okata Y, Hines OJ, Wente MN, Eibl G, Duffy JP, Delano MJ,
Reber HA: Mutation Analysis of the RET receptor in human pancreatic
cancer: Department of Surgery, The David Geffen School of Medicine
at the University of California, Los Angeles, CA. Abstract Accepted:
Association of Academic Surgery 36th Annual Meeting, Boston, MA,
November 7-9, 2002.
26. Delano MJ, Gravelle S: Assembly of a Teltron X-ray
Diffractometer to conduct single crystal and silicon powder
analysis: Chemistry Department, Saint Vincent College, Latrobe, PA.
Abstract and Poster Presentation: American Chemical Society National
Convention 1996, New Orleans, LA.
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