Department Name

RESEARCH INTERESTS:

PGY 5 Categorical Surgery Resident and T32 Research Fellow in the Laboratory of Inflammation Biology and Surgical Science under the direction of Dr. Lyle L. Moldawer, in the Department of Surgery at the University of Florida. Dr. Delano is also perusing a doctoral degree with a concentration in Immunology, in the Department of Immunology and Microbiology through the Interdisciplinary Program in Biomedical Sciences at the University of Florida. After finishing his qualifying exam, entitled Impact of Immature Myeloid Cells in Sepsis in the fall of 2006, Dr. Delano is now on track to defend his thesis in the spring of 2008.

His research interest before coming to the University of Florida focused on the role of chemokine signaling in pancreatic cancer metastasis while working in the Ronald Hirshberg Translational Pancreatic Cancer Laboratory under the direction of Dr. Howard Reber, at The David Geffen School of Medicine at UCLA.  At present, Dr. Delano's research interests have shifted focus to concentrate on the immune responses that occur during sepsis.  His current projects include investigating the interactions of T lymphocytes, dendritic cells, and immature myeloid cells and their role in the development and propagation of the sepsis syndrome.  In addition he is also investigating the human inflammatory reaction to trauma, sepsis, and cardiopulmonary bypass by evaluating the genomic, proteomic, and cellular immune phenotypes that result from these various insults.

CURRENT PROJECTS:

1.)   To determine the role that T regulatory lymphocytes play in the development and propagation of the sepsis syndrome.

2.)   To investigate novel immature myeloid cell populations that have immune modulatory effects during the sepsis syndrome.

3.)   To investigate the immunomodulatory effects that sepsis has on the host immune system and how those effects can be ameliorated with various therapeutic interventions. 

4.)   To determine the human genomic and proteomic responses to cardiopulmonary bypass and elucidate the elements that mediate systemic inflammation.  

5.)   To use the prospectively collected data compiled by the Inflammation and the Host Response to Injury collaborative research program and determine what genomic and proteomic elements predispose trauma patients to a poor outcome.

AWARDS:

FINALIST: A.E. BAUE RESEARCH AWARD.
Selected as one of the top 10 abstracts out of over 500 abstracts at the 7th World Congress on Trauma, Shock, Inflammation and Sepsis.
M.J. Delano, P.O. Scumpia, K. O'Malley, J. Wynn, and L. Moldawer. Sepsis Reprograms Bone Marrow Hematopoiesis Toward The Myeloid Lineage In A MyD88 And TRIF Dependent Manner. Accepted Abstract and Oral Presentation. 7th World Congress on Trauma, Shock, Inflammation and Sepsis - TSIS 2007, March 13-17, 2007, Munich, Germany.

RECIPIENT: CLINICAL/TRANSLATIONAL SCIENCE RESEARCH AWARD.
M.J. Delano, G.M. Janelle, P.O. Scumpia, K. O'Malley, R. Ungaro, C.L. Tannahill, E.D. Staples, T. Martin, L.L. Moldawer, and P.J. Hess. Aprotinin Attenuates The Immuno-inflammatory Response And Alters Blood Monocyte Gene Expression Following Cardiopulmonary Bypass. Award Received: April 20, 2007, Department of General Surgery, University of Florida School of Medicine, Gainesville, FL.

RECIPIENT: THE DR. HERMAN BROWN AWARD FOR EXCELLENCE IN THE STUDY OF THE ART AND SCIENCE OF SURGERY. Awarded for excellence in both patient care and surgical research. Award Received: May 22, 2003, Temple University School of Medicine, Department of General Surgery.

RECIPIENT: ASSOCIATION OF ACADEMIC SURGERY 2003 STUDENT RESEARCH AWARD.
Delano MJ, Duffy JP, Fisher C, Hines OJ, Reber HA: Cellular and Molecular Expression of CXCR4 in Human Pancreatic Cancer Cell Lines: Department of Surgery, The David Geffen School of Medicine at the University of California, Los Angeles, CA. Abstract Accepted: March 28, 2003, Association of Academic Surgery 2003 Student Research Award

RECIPIENT: 2003 TEMPLE UNIVERSITY SCHOOL OF MEDICINE STUDENT RESEARCH DAY AWARD
Delano MJ, Duffy JP, Fisher C, Hines OJ, Reber HA: Cellular and Molecular Expression of CXCR4 in Human Pancreatic Cancer Cell Lines: Department of Surgery, The David Geffen School of Medicine at the University of California, Los Angeles, CA; Department of Surgery, Temple University School of Medicine, Philadelphia, PA. Oral Poster Presentation: April 16, 2003, Temple University School of Medicine Student Research Award 2003

NOMINATED: ASSOCIATION OF ACADEMIC SURGERY 2002 MEDICAL STUDENT RESEARCH AWARD.
Delano MJ, Duffy JP, Hines OJ, Reber HA: The role of CXCR4 and SDF-1 in pancreatic cancer invasion and metastasis: Department of Surgery, The David Geffen School of Medicine at the University of California, Los Angeles, CA
Submitted: March 29, 2002, Association of Academic Surgery 2002 Student Research Award.

BIBLIOGRAPHY:

Publications

1. Delano MJ, Janelle GM, Scumpia PO, O'Malley K, Ungaro R, Tannahill CL, Staples ED, Martin T, Moldawer LL, Hess PJ. The Effect of Aprotinin on the Immuno-inflammatory Response and Blood Monocyte Gene Expression in Response to Cardiopulmonary Bypass. (Manuscript in Preparation) 2007

2. James L. Wynn, Philip O. Scumpia, Robert D. Winfield, Matthew J. Delano, Tolga Barker, Minoru Satoh, Ricardo Ungaro, Ofer Levy, Lyle L. Moldawer. Defects in Innate Immunity Predispose Neonates To Poor Outcome From Sepsis, But Can Be Overcome By Select Toll Like Receptor Agonists. (Submitted Manuscript: Nature Medicine) 2007

3. Delano MJ, Hochwald SN, Garces CA, Cance WG, Grobmyer SR. Preoperative Predictors of Intraoperative Blood Transfusion Requirement for Patients Undergoing Pancreaticoduodenectomy. (Manuscript in Preparation) 2007

4. Matthew J. Delano, Philip O. Scumpia, Jason S. Weinstein, Kindra M. Kelly-Scumpia, Kerri A. O'Malley, James Wynn, Robert D. Winfield, Claudia Moreno, Reuben Ramphal, Wesley H. Reeves, Michael Clare-Salzler, Lyle L. Moldawer. IL-4, IL-10 and CCR2 Signaling Do Not Contribute to the Increased Myeloid Derived Suppressor Cell Numbers or Function During Polymicrobial Sepsis. (Invited Manuscript) 2007

5. Matthew J. Delano, Philip O. Scumpia, James L. Wynn, Kerri O'Malley, Claudia Moreno, Robert D. Winfield, Lyle L. Moldawer. Myeloid-Derived Suppressor Cells and their Contribution to Post-Injury and Sepsis Immune Suppression. (Invited Manuscript) 2007

6. Scumpia PO, Delano MJ, Kelly-Scumpia KM, Weinstein JS, Wynn JL, Winfield RD, Xia C, Chung CS, Ayala A, Atkinson MA, Reeves WH, Clare-Salzler MJ, Moldawer LL. Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis. Blood. 2007 Aug 9; [Epub ahead of print]

7. Wynn JL, Scumpia PO, Delano MJ, O'Malley KA, Ungaro R, Abouhamze A, Moldawer LL. Increased Mortality and Altered Immunity in Neonatal Sepsis Produced by Generalized Peritonitis. Shock. 2007 Jul 5; [Epub ahead of print]

8. Delano MJ, Scumpia PO, Weinstein JS, Coco D, Nagaraj S, Kelly-Scumpia KM, O'Malley KA, Wynn JL, Antonenko S, Al-Quran SZ, Swan R, Chung CS, Atkinson MA, Ramphal R, Gabrilovich DI, Reeves WH, Ayala A, Phillips J, Laface D, Heyworth PG, Clare-Salzler M, Moldawer LL. MyD88-Dependent Expansion of an Immature GR-1+CD11b+ Population Induces T-Cell Suppression and TH2 Polarization in Polymicrobial Sepsis. J Exp Med. 2007 Jun 11; 204(6):1463-74. Epub 2007 Jun 4

9. Iwakuma, N., Sharma, P., Delano, M.J., Moldawer, L., Moudgil, B., Grobmyer, S.R. Differential Uptake of PEG-FITC Silica Nanoparticles by Human Breast Cancer Cells and Normal Human Breast Epithelial Cells. NSTI Proceedings 2:348-349, 2007.

10. Scumpia PO, Delano MJ, Kelly KM, O'Malley KA, Efron PA, McAuliffe PF, Brusko T, Ungaro R, Barker T, Wynn JL, Atkinson MA, Reeves WH, Clare-Salzler MJ, Moldawer LL. Increased natural regulatory T cells and their suppressor activity does not influence mortality in murine polymicrobial sepsis. Journal of Immunol 2006 Dec 1; 177(11)

11. Cuenca AG, Jiang H, Hochwald SN, Delano M, Cance WG, Grobmyer SR. Emerging Implications of Nanotechnology on Cancer Diagnostics and Therapeutics. Cancer. 2006 Aug 1;107(3):459-66

12. Delano MJ, Moldawer LL. The Origins of Cachexia in Acute and Chronic Inflammatory Diseases. Nutr Clin Pract. 2006 Feb;21(1):68-81

13. Dempsey DT, Delano M, Bradley K, Kolff J, Fisher C, Caroline D, Gaughan J, Meilahn JE, Daly JM. Laparoscopic esophagomyotomy for achalasia: does anterior hemifundoplication affect clinical outcome? Annals of Surgery. June 2004; 239:6

14. Duffy JP, Delano MJ, Reber HA: Pancreatic Surgery. Current Opinion in Gastroenterology: 2002; 18:568-573.


Published Abstracts

1. M.J. Delano, G.M. Janelle, P.O. Scumpia, K. O'Malley, R. Ungaro, C.L. Tannahill, E.D. Staples, T. Martin, L.L. Moldawer, and P.J. Hess. Aprotinin Attenuates The Immuno-inflammatory Response And Alters Blood Monocyte Gene Expression Following Cardiopulmonary Bypass. Surgery Research Symposium, Award Received: April 20, 2007, Department of General Surgery, University of Florida School of Medicine, Gainesville, FL.

2. MJ Delano M.D; CA Garces MD; WG Cance MD; SN Hochwald MD; SR Grobmyer MD. Preoperative Predictors of Intraoperative Blood Transfusion Requirement for Patients undergoing Pancreaticoduodenectomy. Accepted Abstract and Poster Presentation, AHPBA Annual Meeting, April 19-22, 2007.

3. Steven N. Hochwald, Stephen R. Grobmyer, Eleanor Curran, Matthew Delano, Alan W. Hemming, William G. Cance, Stephen B. Vogel. Braun enteroenterostomy is associated with reduced delayed gastric emptying and early resumption of oral feeding following pancreaticoduodenectomy. Accepted Abstract and Poster Presentation, AHPBA Annual Meeting, April 19-22, 2007.

4. Delano, M.J., Scumpia, P.O., O'Malley, K., Wynn, J., Winfield, R. and Moldawer, L.L. Sepsis Reprograms Bone Marrow Hematopoesis Toward The Myeloid Linage In A MyD88 And TRIF Dependent Manner. Accepted Abstract and Oral Presentation. 7th World Congress on Trauma, Shock, Inflammation and Sepsis - TSIS 2007, March 13-17, 2007, Munich, Germany.

5. Wynn, JL, Scumpia, PO, Winfield, RD, Delano, MJ, O'Malley, K, Ungaro, R, Abouhamze, A, Moldawer, LL. Improved Survival in Neonatal Mice with Sepsis Following TLR Agonist Treatment. Accepted Abstract and Oral Presentation. 7th World Congress on Trauma, Shock, Inflammation and Sepsis - TSIS 2007, March 13-17, 2007, Munich, Germany.

6. Scumpia PO, Delano MJ, Kelly KM, Weinstein JS, Clare Salzler MJ, Moldawer LL. Treatment with anti-GITR agonistic antibody corrects T cell dysfunction and improves survival in murine sepsis. Accepted Abstract and Oral Presentation. 7th World Congress on Trauma, Shock, Inflammation and Sepsis - TSIS 2007, March 13-17, 2007, Munich, Germany.

7. MJ Delano M.D; CA Garces MD; WG Cance MD; SN Hochwald MD; SR Grobmyer MD. Preoperative Predictors of Intraoperative Blood Transfusion Requirement for Patients undergoing Pancreaticoduodenectomy. Accepted Abstract and Poster Presentation, AHPBA Annual Meeting, April 19-22, 2007.

8. Matthew J. Delano, M.D., Philip O. Scumpia, B.S., Ricardo Ungaro, B.S., Cynthia L. Tannahill, M.S., Kerri O' Malley, Ph.D., Gregory M. Janelle, M.D., Amer Abouhamze, M.S., Thomas D. Martin, M.D., Edward D. Staples, M.D., Walter W. Scott, M.D., Lyle L. Moldawer, Ph.D., Philip J. Hess, M.D. Genomic and Proteomic Responses after Cardiopulmonary Bypass Indicate Innate Immune System Dysfunction. Accepted Abstract and Oral Presentation Society of Thoracic Surgeons Annual Meeting San Diego, CA. January 28-30, 2007.

9. Azra Bihorac, Matthew Delano, Andrea Gabrielli, Avery B. Nathens, Ronald V. Maier, A. Joseph Layon, and Lyle L Moldawer. Incidence, clinical predictors, and outcome of acute kidney injury among trauma patients. Accepted Abstract and Poster Presentation, American Society of Nephrology 39th Annual Meeting and Scientific Exposition, November 14-19, 2006. San Diego, CA.

10. Matthew J. Delano, M.D., Azra Bihorac, M.D., Philip O. Scumpia, B.S., Avery B, Nathens, M.D., Ronald G. Maier, M.D., Joseoh A. Layon, M.D., Lyle L. Moldawer, Ph.D. Early Genomic and Proteomic Changes in Trauma Patients With Acute Kidney Injury Suggest Early Immune Dysfunction. Accepted Abstract and Poster Presentation, Innate Immunity Meeting, SLB, ISER, San Antonio, TX. November 9-11, 2006.

11. Qizhi Zhang, Ph.D., Matthew Delano, M.D., Huabei Jiang, Ph.D., Stephen R. Grobmyer, M.D. Gold Nanoparticles as a Contrast Agent for High Resolution in Vivo Imaging Using Photoacoustic Tomography. Accepted Abstract and Oral Presentation, International Nanoparticle Congress, San Francisco, CA. November 1-3, 2006.

12. MJ Delano, PO Scumpia, K O'Malley, J Wynn, R Ungaro, C Tannahill, L Lottenberg, LL Moldawer. Immature Myeloid Cell Activity in a Murine Polymicrobial Sepsis Model. Accepted Abstract and Poster Presentation, AAST Meeting, New Orleans, LA September 28-30, 2006.

13. M. Delano, P. Scumpia, K. O'Malley, J. Wynn, R. Ungaro, L. Moldawer. Regulation of GR-1+CD11b+ Myeloid Suppressor Cells in Murine Polymicrobial Sepsis. Shock 2006 June (25)1:64. Supplement.

14. Scumpia PO, Delano MJ, Moldawer LL. Regulatory T cells are increased but do not participate in mortality in murine polymicrobial sepsis. Shock 2006 June (25)1:8. Supplement.

15. Scumpia PO, Weinstein JS, Delano MJ, Kelly KM, Reeves WH, Clare-Salzler MJ, Moldawer LL. B cell dysfunction in sepsis is T cell dependent. Leuk Biol Supplement (accepted).

16. M. Delano, P. Scumpia, K. O'Malley, J. Wynn, R. Ungaro, C. Tannahill, A. Abouhamze, L. Moldawer. Regulation of GR-1+CD11b+ Myeloid Suppressor Cells in Murine Polymicrobial Sepsis. Oral Presentation: Department of Surgery Research Day, University of Florida, March 31, 2006.

17. Daniel T. Dempsey, M.D., Matthew Delano, M.D., Kevin Bradley, M.D., Jeffrey Kolff, M.D., Carol Fisher, B.A., Dina Caroline, M.D.*, John Gaughan, Ph.D.#, John E. Meilahn, M.D., John M. Daly, M.D.: Laparoscopic esophagomyotomy for achalasia: does anterior hemifundoplication affect clinical outcome?: Departments of Surgery, Radiology*, and Biostatistics#, Temple University School of Medicine, Philadelphia, PA. Abstract Presented: Southern Surgical Association Meeting, December, 2003, Hot Springs, VA.

18. Delano MJ, Duffy JP, Fisher C, Hines OJ, Reber HA: Cellular and Molecular Expression of CXCR4 in Human Pancreatic Cancer Cell Lines: Department of Surgery, The David Geffen School of Medicine at the University of California, Los Angeles, CA. Abstract and Poster Presentation: March 28, 2003, Association of Academic Surgery 2003 Student Research Award (AWARD RECIPIENT).

19. Delano MJ, Duffy JP, Fisher C, Hines OJ, Reber HA: Cellular and Molecular Expression of CXCR4 in Human Pancreatic Cancer Cell Lines: Department of Surgery, The David Geffen School of Medicine at the University of California, Los Angeles, CA; Department of Surgery, Temple University School of Medicine, Philadelphia, PA. Abstract and Poster Presentation: April 16, 2003, Temple University School of Medicine Research Day 2003 (AWARD RECIPIENT).

20. JP Duffy, HA Reber, MN Wente, G Eibl, Y Okada, M Delano, OJ Hines: Vitronectin stimulates mitogen-activated protein kinase activity in human pancreatic cancer cells: Department of Surgery, The David Geffen School of Medicine at the University of California, Los Angeles, CA. Poster Presentation: 6th Annual Longmire Surgical Society Scientific Day, UCLA, March 22, 2002.

21. Eibl G, Okada Y, Reber HA, Duffy J, Delano M, Wente MN, Hines OJ: Prostaglandin E2 is mitogenic and increases VEGF in human pancreatic cancer cells: Department of Surgery, The David Geffen School of Medicine at the University of California, Los Angeles, CA. Abstract Accepted: American College of Surgeons 88th Annual Clinical Congress, San Francisco, CA, October 6-10, 2002.

22. Eibl G, Okada Y, Reber HA, Duffy J, Delano M, Wente MN, Hines OJ: PPAR-γ stimulates plasminogen activator inhibitor-1 and decreases urokinase-type plasminogen activator levels in human pancreatic cancer cells: Department of Surgery, The David Geffen School of Medicine at the University of California, Los Angeles, CA. Oral Presentation Accepted: Association of Academic Surgery 36th Annual Meeting, Boston, MA, November 7-9, 2002.

23. Duffy J, Eibl G, Okada Y, Delano M, Reber H, Hines J: Vitronectin stimulates p44/42 mitogen-activated protein kinase in human pancreatic cancer cells: Department of Surgery, The David Geffen School of Medicine at the University of California, Los Angeles, CA. Oral Poster Presentation Abstract Accepted: Association of Academic Surgery 36th Annual Meeting, Boston, MA, November 7-9, 2002.

24. John P. Duffy, Howard A. Reber, Guido Eibl, Yuji Okada, Moritz N. Wente, Matthew J. Delano, Oscar J. Hines: Evidence for vitronectin autocrine regulation in pancreatic cancer cells. Department of Surgery, The David Geffen School of Medicine at the University of California, Los Angeles, CA. Abstract and Poster Presentation Accepted: American Pancreatic Association Annual Meeting, November 14-15, 2002.

25. Okata Y, Hines OJ, Wente MN, Eibl G, Duffy JP, Delano MJ, Reber HA: Mutation Analysis of the RET receptor in human pancreatic cancer: Department of Surgery, The David Geffen School of Medicine at the University of California, Los Angeles, CA. Abstract Accepted: Association of Academic Surgery 36th Annual Meeting, Boston, MA, November 7-9, 2002.

26. Delano MJ, Gravelle S: Assembly of a Teltron X-ray Diffractometer to conduct single crystal and silicon powder analysis: Chemistry Department, Saint Vincent College, Latrobe, PA. Abstract and Poster Presentation: American Chemical Society National Convention 1996, New Orleans, LA.