Department Name

Philip J. Hess, Jr. M.D.

 CO-PRINCIPAL INVESTIGATOR:
Prospective, randomized, blinded trial of Aprotinin in CABG/CPB Trial
Evaluating the immuno-inflammatory response
Co-PI: Hess & Janelle CI: Beaver, Martin, Scott, Staples

CO-INVESTIGATOR:
MicroMed DeBakey VAD Phase II Trial
Designed as bridge to transplant
CO-PI: Staples & Klodell CI: Beaver, Hess Martin, Aranda, Schofield, Hill, Pauly


MicroMed DeBakey VAD Phase II Trial
Destination therapy.
CO-PI: Klodell & Staples CI: Beaver, Hess, Martin, Aranda, Schofield, Hill, Pauly

ECLIPSE - SNP Trial
Prospective, open label, randomized trial comparing Clevelox to Nipride for peri & post op HTN
PI: Klodell CI: Beaver, Hess, Martin, Staples & cardiac anesthesiologists

AVANT Immunotherapeutics, Inc.
TP10 complement inhibitor for women undergoing CABG w/CPB
PI: Klodell CI Beaver, Hess Martin Staples, & cardiac anesthesiologists

PRIMO-CABG II Trial
Complement inhibitor for CABG & CABG/valve surgery
PI: Janelle CI: Beaver, Hess, Klodell, Martin, Staples & cardiac anesthesiologists

Myocor Coapsys Annuloplasty System
Mitral valve repair without the use of CPB or an atriotomy
PI: Staples CI: Beaver, Hess, Klodell, Martin, Scott, Botero, Julkarni, Peng, Urdaneta

Critical Therapeutic Study
Phase II investigational drug study involving CTI-01 which is an antioxidant/anti-inflammatory agent for CABG/valve pts.
PI: Klodell CI: Beaver, Hess, Martin, Staples and cardiac anesthesiologists

Scios Natrecor Study
Natrecor vs placebo for CABG or CABG/mitral procedures at AGH
PI: Beaver CI: Hess, Klodell, Martin, Scott, Staples, Janelle

CRT-CABG (Medtronic, Inc.)
Evaluate benefit of different pacing modalities for CHF
CO-PI Beaver & Conti CI: Hess, Klodell, Martin, Scott, Staples

Intravenous Sildenafil for Pulmonary Hypertension in Cardiac Surgery
Funding to be reviewed by Pfizer in April
PI: Beaver CI: Lobato, Hess, Klodell, Martin, Scott, Staples

STITCH Trial
Three randomization stratums & registry
Lead PI: Hill Surgical PI: Beaver Co-Surgical PI: Klodell, Staples
(SVR & CABG, Hess (CABG)

Prophylactic Use of Nesiritide for the prevention of ARF in TAAA Surgery patients.
PI: Ejaz CO-PI: Johnson, Alexander, Beaver, CI: Munjal, Fancher, Winterstein, Hartzema, Finlay, Gerhard, Hess, Martin, Klodell.

Metronic Talent Stent Graft
Stent graft for thoracoabdominal aneurysm
PI: Lee CI: Beaver, Hess, Klodell, Martin

Race, HTN & Vascular Adrenoceptor Gene Expression
PI: Jennifer Dungan, MSN,ARNP CI: Hess

RESEARCH PROJECTS COMPLETED:

Cerebral optimization by regionalization of the aorta:  Evaluation of the Cardeon Cobra Catheter.

A prospective clinical trial for the assessment of safety and efficacy of InterVascular's InterGard Silver Antimicrobial Collagen Coated Vascular Prosthesis for the treatment of aneurysmal and occlusive disease. 

The EXPEDITION Trial:  Na+/H+ Exchange inhibition to prevent coronary events in acute cardiac conditions.

Milrinone Trial:  Blinded study comparing the effects of continuous administration of Milrinone or placebo on the levels of myocardial c'AMP, cytokines and TEE variables before and after x-clamp placement.

Phase III Comparison of Neutralase to Protamine during CABG Surgery.

Baxter/Cerus:  Treated red blood cell use in patients requiring acute transfusion support. 

Evaluation of the Pro-Inflammatory Cytokine Response to lung transplantation and its prognostic role in post-transplant reperfusion edema.

American College of Surgeons Oncology Group (ACOSOG) Protocol Z0030:  Randomized Trial of Mediastinal Lymph Node Sampling versus Complete Lymphadenectomy During Pulmonary Resection in the Patient with N0 or N1 (less than hilar) Non-Small Cell Carcinoma.

Celecoxib Prophylaxis in the Prevention of Postoperative Atrial Fibrillation

J & J /Scios - Natrecor Project; Prospective enrollment with Pro-BNP/Aldosterone/Endothelin measurements.

Evaluation of the Topical Hemostatic Efficacy and Safety of Fibrin Sealant Vapor Heated, Solvent/Detergent Treated Compared with Currently Licensed TISSEEL VH Fibrin Sealant in Subjects Undergoing Cardiac Surgery (Baxter Protocol #550003).

Grants:

2003-2004
Submitted to Howard Hughes Research Foundation in the amount of $29,000.00
Ultrafiltration following cardiopulmonary bypass reduces the immuno-inflammatory response, and limits the hemodynamic instability following CABG. 

2003-2004
Submitted to Bayer in the amount of $25,000.00
Aprotinin administration during cases involving cardiopulmonary bypass reduces the immuno-inflammatory response, reduces neurocognitive impairment, and reduces overall morbidity following CABG

PUBLICATIONS:

1. Hess PJ, Vauthey JN.  Gallbladder cancer in the era of laparoscopic cholecystectomy.  G.I. Cancer Letter.  Eds, Vauthey JN, Lauwers GY.  University of Florida, Fall 1995, 2(4):1.

2. Edwards PD, Solorzano CC, Hess PJ, Pruitt JH, Tannahill CL, Abouhamze AS, Abouhamze ZS, Kaibara A, Auffenberg T, Philip R, Philip M, Copeland EM, MacKay SLD, Moldawer LL.  Cationic liposome-mediated gene transfer:  Tissue specificity, duration and effect of acute inflammation.  Journal of Biological Chemistry, 1996.

3. Solorzano CC, Kaibara A, Pruitt JH, Edwards PD, Hess PJ, Ksontini R, Abouhamze A, Auffenberg T, MacKay SLD, Copeland EM, Moldawer LL.  Mice lacking a functional IL-1 type 1 but not a TNF type 1 receptor exhibit an attenuated acute phase response in acute inflammation.  Surgical Forum, 1996.

4. Hess PJ, Seeger JM, Huber TS, Welborn MB, Martin TD, Harward TRS, Duschek S, Edwards PD, Solorzano CC, Copeland EM, Moldawer LL.  Exogenously administered interleukin-10 decreases pulmonary neutrophil infiltration in a TNF-dependent murine model of acute visceral ischemia.  Journal of Vascular Surgery 1997 Jul 26(1):113-18.

5. Engles RE, Huber TS, Zander DS, Hess PJ, WelbornMB, Moldawer LL, Seeger JM.  Exogenous human recombinant interleukin-10 attenuates hindlimb ischemia-reperfusion injury.  Journal of Surgical Research, 1997 May 69(2):425-8.

6. Solorzano CC, Pruitt JH, Ksontini R, Hess PJ, Edwards PD, Kaibara A, Abouhamze A, Auffenberg T, Galardy R, Vauthey JN, Copeland EM, Edwards C, Lauwers GY, Clare-Salzler M, MacKay SLD, Moldawer LL, Lazarus D.  Involvement of 26kD cell-associated TNFa in experimental hepatitis and exacerbation of liver injury with a matrix metalloproteinase inhibitor.  Journal of Immunology, 1997 Jan 1;158(1) 414-9.

7. Solorzano CC, Kaibara A, Hess PJ, Edwards PD, Ksontini R, Abouhamza A, McDaniel S, Frazier J, Trujillo D, Kieft G, Seely J, Kohno T, Cosenza ME, Clare-Salzler M, MacKay SLD, Martin SW, Moldawer LL, Edwards CK.  Pharmacokinetics, immunogenicity, and efficacy of dimeric TNFR binding proteins in healthy and bacteremic baboon.  J of Appl Physiol 1998 Apr,84(4):1119-30.

8. Welborn MB, Hess PJ, Oldenburg HAS, Huber TS, Martin TD, Rauwerda JA, Wesdorp RIC, Copeland EM, Moldawer LL, Seeger JM.  The relationship between visceral ischemia, proinflammatory cytokines and organ injury in patients undergoing thoracoabdominal aortic aneurysm repair.  Critical Care Medicine 2000 SepVol 28(9)3191-7.

9. Blas ML, Janelle GM, Urdaneta F, Briesacher K, Botero M, Olin D, Hess P, Lobato EB:  Myocardial ischemia/infarction following cardiopulmonary bypass during coronary artery grafting: does the inotrope matter, abstracted.  Anesthesiology.  In preparation.

10. Klodell CT; Hess PJ; Martin TD; and Beaver TM:  Impending Aortic Penetration following Thoracolumbar Spinal Fixation.  American Surgeon submitted Nov 03.

11. Holt Richard L, Martin Tomas D, Hess Philip J, Beaver Thomas M, and Klodell Charles T.  Jehovah's Witnesses Requiring Complex Urgent Cardiothoracic Surgery.  Ann of Thorac Surg 2004 Aug (2);78:695-7.

12. Klodell Charles T, Hess Philip J, Beaver Thomas M, Clark Timothy D and Martin Tomas D.  "Distal Aortic Perfusion During Aortic Arch Reconstruction - Another Tool for the Aortic Surgeon.  Ann of Thorac Surg 2004 Dec (6);78:2196-8.

13. Trachte Aaron L, Lobato Emilio B, Urdaneta Felipe, Klodell Charles, Staples Edward D, Hess Philip J, Martin Tomas D, Beaver Thomas M.  Oral Sildenafil reduces pulmonary hypertension following cardiac surgery.  Ann of Thorac Surg 2005 Jan;79(1):194-7.

14. Hess Philip J, Klodell Charles T, Beaver Thomas M and Martin TD.  The Florida Sleeve:  A New Technique for Aortic Root Remodeling with Preservation of the Aortic Valve and Sinuses.  Ann of Thorac Surg 2005 Aug.;80(2):748-50.

15. Beaver T, Herrbold F, Hess P, Klodell C, Martin TD:  Transferring Diagnosis vs. Actual Diagnosis at a Center for Thoracic Aortic Disease.  Ann Thorac Surg 2005 June,79(6):1957-60.

16. Jose Erbella, Thomas S. Huber and Philip J. Hess:  Superior Vena Cava Bypass with Superficial Femoral Vein for Benign Superior Vena Cava Syndrome. Submitted to Vas Surgery, May 2005.

17. Beaver TM, Martin TD, Klodell CT, Hess PJ, Garvan-Wilson CJ, Janelle GM, Staples ED, Lobato EB:  Circulatory arrest during ascending and proximal aortic arch repair: a retrospective review (In preparation)

18. Mathur A, Baz M, Staples ED, Bonnell M, Hess PJ, Klodell CT, Moldawer LL Beaver TM Cytokine profile following lung transplantation: correlation with reperfusion injury. (In preparation).

19. Hess, PJ:  The Systemic Inflammatory Response to Coronary Artery Bypass Graft Surgery.  Accepted to American Journal of Health-System Pharmacy 2005.

ABSTRACTS:

1. Hess PJ, Welborn MB, Solorzano CC, Edwards PD, Auffenberg T, Abouhamze A, Abouhamze Z, Moldawer LL, Exogenous IL-10 suppresses tumor necrosis factor (TNF) dependent pulmonary neutrophil infiltration in a mouse model of visceral ischemia-reperfusion injury.  Conference on Tumor Necrosis Factors and Related Molecules, 6^th International TNF Congress, Rhodes, Greece, May 1996.

2. Solorzano CC, Hess PJ, Clare-Salzler M, Galardy RE, Moldawer LL, Lazarus DD.  Involvement of Cell-associated TNFa in a model of experimental hepatitis.  Conference of Tumor Necrosis Factors and Related Molecules, 6^th International INT Congress, Rhodes, Greece, May 1996.

3. Hess PJ, Welborn MB, Duschek BS, Harward TRS, Huber TS, Moldawer LL, Seeger JM.  IL-10 is released following visceral ischemia and exogenous IL-10 suppress pulmonary neutrophil infiltration.  The International Society of Cardiovascular Surgery 44^th Scientific Meeting, Chicago, IL June 1996.

4. Hess, PJ, Welborn MB, Seeger JM, Harward TRS, Huber TS, Copeland EM, Moldawer LL, Martin TD.  Left atrial femoral bypass decreases visceral ischemia time in thoracoabdominal aortic aneurysm repair and the systemic TNFa, IL-10 and P75 response.  The Association for Academic Surgery 30^th Annual Meeting, Chicago, IL, November 1996.

5. Blas ML, Janelle GM, Urdaneta F, Briesacher K, Botero M, Olin D, Hess P, Lobato EB:  Myocardial ischemia/infarction following cardiopulmonary bypass during coronary artery grafting: does the inotrope matter.  Anesthesiology Vol 93 Page A, 2000.

6. Martin TD, Bonnel M, Beaver TM, Hess P, Staples ED, Knauf DG, Alexander JA, Spotnitz WD.  Homograft aortic root replacement for aortic endocarditis in high-risk patients.  American College of Chest Physicians, San Diego, CA November 2002.

7. Martin, Tomas D, Hess, Philip J, Klodell, Charles T., Alexander, James A, Staples, Edward D, Knauf, Daniel G, Spotnitz, William:  Valve Sparing Aortic Root Reconstruction - A Simplified Technique, Southern Thoracic Surgical Association 50^th Anniversary Annual Meeting in Bonita Springs, Florida, November 13, 2003.

8. Beaver TM, Martin TD, Klodell C, Hess P, Felger J, Carrie R, Wilson-Garvan C, Janelle G, Staples E, Knauf D, Alexander JA, Spotnitz WD.  Safety and efficacy of aprotinin in circulatory arrest.  Presented at the 50^th annual meeting of The Southern Thoracic Surgical Association, Bonita Springs, FL, November 13-15, 2003.

9. Herrbold Francis, Martin Thomas, Hess Philip, Klodell Charles, Spotnitz William, and Beaver Thomas.  Transferring Diagnosis vs. Actual Diagnosis at a Center for Thoracic Aortic Disease.  Aortic surgery Symposium IX, Sheraton New York Hotel and Towers, April 22-23, 2004.  Poster accepted for presentation. 

10. Mathur AK, Staples ED, Baz MA, Hess Jr PJ, Klodell CT, Knauf DG, Moldawer LL, Beaver TM.  Cytokine Production Following Lung Transplantation:  Correlation With Reperfusion Injury.  Presented at the STS 41^st Annual Meeting in Tampa, Florida, January 24-26, 2005.

11. Klodell, Charles T Jr., Morey, Timothy E, Aranda Juan M Jr., Staples, Edward D, Martin Tomas D, Hess, Philip J, Beaver Thomas M, Knauf Daniel G, Hill James A, Pauly Daniel F, Schofield Richard S.  Risk Factors for Pericardial Effusions Necessitating Surgical Drainage Following Orthotopic Heart Transplantation.  Abstract submitted to Southern Thoracic.  February 2005.

12. Janelle G, Peng Y, Klodell C, Hess P.  Chronic Pulmonary Embolism in a Patient Presenting for Orthotopic Heart Transplant.  Anesthesia and Analgesia 2005:100,SCA1-116

CASE REPORTS: 

1. Liu, Shuguang; Hess, Philip J.; Naik, Bhiken; Zumberg, Marc; Janelle, Gregory:  Control of Refractory Bleeding Using Recombinant Factor VIIa in a Post-Cardiac Transplant Patient Undergoing Biventricular Assist Device Placement.  Submitted to Anesthesia and Analgesia, Sept. 2003.

2. Holt, Richard L, Martin Tomas D, Hess Philip J, Beaver Thomas M, and Klodell Charles T.:  Jehovah's Witnesses Requiring Complex Urgent Cardiothoracic Surgery.  Ann Thorac Surg Aug 2004;78(2):695-7.

3. Smith, Karen; Williams, Kevin; Hess, Philip.  Cardiac Mass Diagnosed by Angiography During Coronary Intervention.  March 2005.

PRESENTATIONS:

"Lung Cancer" presented at Grand Rounds at the University of Florida, October 25, 2001.

"Surgical Treatment of Aortic Disease", 9^th Annual Cardiovascular Symposium at South Georgia Medical Center in Valdosta, Georgia April 4, 2003.

"Lung Cancer" presented at University of Florida School of Medicine basic science lecture series November 2003 and February 2004

"Acute Aortic Dissection" presented at the Cobe CarboMedics Summit Seminar, Keystone, Colorado March 19, 2004 

"Aortic Dissection", presented at the Advances in Critical Care Conference 2004 at the University of Florida, Gainesville, Florida.  May 20, 2004. Carolina Valve Symposium in Greenville, NC September 23-29, 2004.

"Blood Conservation in Cardiac Surgery", Lakeland Regional Medical Center, Lakeland, FL.  November 11, 2004 Presentation of M & M at the Surgical Grand Rounds, at the University of Florida, December 1, 2004

"Advancing Patient Safety and Improving Outcomes in CABG Surgery", American Society of Health-System Pharmacists Annual Meeting in Orlando, Florida. December 6, 2004