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Robin D. Kim
M.D. |
RESEARCH INTERESTS:
Although hepatocellular carcinoma (HCC) is one of the most common
malignancies worldwide, only 10-20% of cases are curable by either
resection or transplantation. Understanding the cellular mechanisms
of HCC proliferation will provide novel methods to interrupt the
growth of these otherwise incurable cancers.
Proliferation of HCC involves partially characterized intracellular
signals that regulate cell cycle progression. Although some members
of the Tumor Necrosis Factor Related (TNFR) superfamily are
involved other closely related
members have not been
examined. The global purpose of this project is to examine newer
members of the TNFR superfamily involved in HCC and their downstream
signals. Our ultimate goal is to assess the potential therapeutic
benefits of exploiting these early events in TNFR superfamily-
mediated signaling in HCC growth.
SUPPORT
1. American College of Surgeons Faculty Research Fellowship
Role: PI
7/1/2006 to 6/30/2008
Title: Strategies Against TNF-Related Proliferative Signaling in the
Treatment of Hepatocellular Carcinoma
2. University of Florida Department of Surgery Research Career
Development Award
Role: PI
7/1/2005 to 6/30/2007
Title: Strategies Against TNF-Related Proliferative Signaling in the
Treatment of Hepatocellular Carcinoma
JOURNAL ARTICLES:
1. Ricciardi R, Foley DP, Quarfordt SH, Kim RD, McLaughlin
TJ, Baker SP, Donohue SE, Wheeler SM, Meyers WC; Alterations
in intrahepatic hemodynamics of the harvested porcine liver. J.
Gastrointest. Surg., 1999, 5 (5): 490
2. Kim RD, Darling CE, Cerwenka H, Chari RS: Hypo-osmotic
Stress Activates p38, ERK 1,2, SAPK/JNK in Rat Hepatocytes..
J. Surg. Res., 2000, 90 (1): 58
3. Ricciardi R, Kim RD, McDade TP, Perugini RA, Quarfordt
SH, Chari RS, Meyers WC; NF-kB Nuclear Expression During
Cold Ischemia Correlates with Post Reperfusion Graft Function.
J. Surg. Res. 2000; 93(1):35-40.
4. Nolan B, Kim RD, Duffy A, Sheth K, De M, Miller-Graziano
C, Chari R, Bankey P. Inhibited PMN Apoptosis: NF-kB
Translocation is Required for TRAF-1 Synthesis. Shock, 2000,
14(3):290
5. Kim RD, Darling CE, Roth TP, Ricciardi R, Chari RS.
Activator protein 1 activation following hypoosmotic stress in
HepG2 cells is actin cytoskeleton dependent. J. Surg. Res., 2001,
100 (2): 176
6. Ricciardi R, Foley DP, Quarfordt SH, Vittimberga FJ, Kim
RD, Donohue SE, Wheeler SM, Anwaruddin S, Callery MP,
Meyers WC. Hemodynamic and Metabolic Variables Predict
Porcine ex Vivo Liver Function. J. Surg. Res., 2001; 96(1):114
7. Ricciardi R, Meyers WC, Schaffer BK, Kim RD, Shah SA,
Wheeler SM, Donohue SE, Sheth KR, Callery MP, Chari RS.
Protein Kinase C inhibition abrogates hepatic ischemic
preconditioning responses. J. Surg. Res., 2001, 97 (2): 144
8. Kim RD, Roth TP, Darling CE, Ricciardi R, Schaffer BK,
Chari RS; Hypoosmotic Stress Stimulates Growth in HepG2 Cells
via PKB-Dependent Activation of AP-1. J. Gastrointest. Surg.,
2001, 5 (5): 546
9. Kim RD, Stein G, Chari RS; The Impact of Cell Swelling on
Proliferative Signal Transduction in the Liver. J. Cell. Biochem.,
2001, 83 (1): 56
10. Shah SA, Potter MW, Hedeshian MH, Kim RD, Chari RS
and Callery MP; PI-3'Kinase and NF-kB cross-signaling in human
pancreatic cancer cells. J. Gastrointest. Surg., 2001, 5(6): 603
11. Ricciardi R, Chari RS, Schaffer BK, Kim RD, Shah SA,
Potter MW, Quarfordt SH, Callery MP, Meyers WC. The
protective effects of ischemic preconditioning on the cold
preserved liver are tyrosine kinase dependent. Transplantation,
2001, 72 (3): 406
12. Kim RD, Nazarey P, Katz E, Chari RS: Laparoscopic staging
and tumor ablation for hepatocellular carcinoma in Child C
cirrhotics evaluated for orthotopic liver transplantation. Surg
Endosc. 2004, 18 (1): 39-44
13. Kim RD, Sakamoto S, Haider MA, Molinari M, Gallinger S,
McGilvray ID, Grant DR, Greig PD, Cattral MS. Role of
magnetic resonance cholangiography in assessing biliary anatomy
in right lobe living donors: correlation with intraoperative
findings. Transplantation 2005, 79 (10): 1417-21
14. Kim RD, Oreopoulos DG, Qiu K, McGilvray ID, Grant DR,
Greig PD, Cattral MS: Impact of mode of dialysis on intra
abdominal infection after simultaneous pancreas-kidney
transplantation Transplantation 2005, 80 (3): 339-343.
15. Kim RD, Kundhal PS, McGilvray ID, Cattral MS, Taylor B,
Langer B, Grant DR, Zogopoulos G, Shah SA, Greig PD,
Gallinger S: Predictors of failure following
pancreaticoduodenectomy for ampullary carcinoma. J Am Col
Surg. (in press)
16. Shah SA, Grant DR, Greig PD, McGilvray ID, Adcock LD,
Girgrah N, Wong P, Kim RD, Smith R, Lilly LB, Levy GA and
Cattral MS. Analysis and outcomes of right lobe living-donor
hepatectomy in 101 consecutive patients. American Journal of
Transplantation. 2005 Nov;5(11):2764-9
17. Shah SA, Greig PD, Gallinger S, Cattral MS, Dixon E, Kim
RD, Taylor BR, Grant DR and Vollmer CM. Factors associated
with early recurrence after resection for hepatocellular carcinoma
and outcomes. J Am Col Surg. (In Press)
18. Kim RD, Levy G, Humar A, Shah SA, Adcock L, Wong P,
Lilly L, Girgrah N, McGilvray ID, Greig PD, Grant DR, Cattral
MS: Clinical risk factors for acute cellular rejection in adult
living
donor liver transplant recipients. Liver Transpl (submitted)
BOOK CHAPTERS:
1. Meyers WC, Kim RD: Pyogenic and Amebic Abscess Liver
Abscess. In Townsend CM, (Ed.): Sabiston Textbook of Surgery: The biological basis of modern surgical practice. Philadelphia,
WB Saunders, 2001, pp 1044-1053.
2. Meyers WC, Kim RD: Echinococcal Cyst. In Townsend CM,
(Ed.): Sabiston Textbook of Surgery: The biological basis of
modern surgical practice. Philadelphia, WB Saunders, 2001, pp
1053-1055.
INTERNET CHAPTERS:
1. Kim RD, Chari RS: Infections and Infestations of the Liver
in Liver Tumors, ed Chari RS www.Yourdoctor.com
(YourDoctor.com, Sausalito, CA), 2000.
2. Kim RD, Chari RS: Cholangiocarcinoma. eds Tanabe KK and
Savarese DS www.UptoDate.com (Up To Date, Wellesley MA)
2000.
3. Czerwenka H, Kim RD, Chari RS.: Current Management of
Portal Hypertension. www.Medvista.com (Med Vista, Palo Alto,
CA), 2000.
4. Kim RD and Chari RS: The Biliary System, in Unbound
Surgery, eds Pappas TN, Eubanks S, Tyler DS, and Purcell GP.
www.unboundmedicine.com , (Salt Lake City, UT) 2000.
5. Kim RD, Chari RS: Infections and Infestations of the Liver
in Liver Tumors, ed Chari RS www.Yourdoctor.com
(YourDoctor.com, Sausalito, CA), 2001, 2002, 2003
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