Trauma, Burns and Emergency Surgery

 
Lawrence Lottenberg
M.D.

RESEARCH INTERESTS:


The Acute Care Surgery Research Program at the University of Florida provides an integrated approach to managing patients with complex medical conditions.  The research activities incorporate the use of a multidisciplinary approach involving the basic and applied sciences.  The research efforts concentrate on improving patient outcomes through the development of new therapies and treatments. The development of new technology is supported by our inclusion in multicenter, industry-sponsored research. Participation in these trials permits access to the most current technologies, and has supported the initiation of investigator-initiated protocols as well. 

As State of Florida Trauma Medical Director, Dr. Lottenberg works with all the Trauma Centers in the State to improve the care of Trauma patients.  By utilizing statewide data sets we plan to identify areas in need of further research and statewide educational planning.  The use of evidenced based practice will assist in improving quality care as well as direct efforts at the legislative level to improve care across the State of Florida. 
 

Research Activities:

1. A Multicenter, Randomized, Open-Label, Phase 3 Study to Compare the Safety and Efficacy of Intravenous Doripenem with that of Intravenous Piperacillin/Tazobactam in Hospital-Acquired Pneumonia.
Funding Agency:  Peninsula Pharmaceuticals
PI
July 5th, 2004-ongoing

2. A Multicenter, Randomized, Open-Label, Phase 3 Study to Compare the Safety and Efficacy of Intravenous Doripenem with that of Intravenous Doripenem with that of Intravenous Imipenem in Ventilator-Associated Pneumonia.
Funding Agency:  Peninsula Pharmaceuticals
Sub Investigator
July 8th, 2004-ongoing


3. Circulating Dendritic Cell Populations in Trauma, Septic and Burn Patients
Funding Agency: University of Florida
Sub investigator
August 4th, 2004-ongoing

4. A Comprehensive Assessment of the Florida Trauma System
Funding Agency: State of Florida Grant
PI
February 8th, 2005-complete

5. A Multicenter, Retrospective, Observational Study to Evaluate Erythropoietic Stimulating Protein (ESP) Use and Clinica Outcomes in Hospitalized Patients (ASSESS)
Funding Agency: Amgen
PI
March 22nd, 2005-complete

6. Analysis for CTGF and TGF-b levels in deep partial thickness thermal burn injury tissue versus normal tissue.
Funding Agency:  Physician Initiated
Sub Investigator
October 5, 2005-ongoing.

7. A Prospective Study to Evaluate the Erythropoietic Responsiveness Associated with Once Weekly (QW) Administration of Darbepoeting alfa (Aranesp) in Patients Admitted to the ICU
Funding Agency:  Jenica Research/Amgen
PI
November 1, 2005- ongoing 

8. Development of a Shark Attack Severity Score using the International Shark Attack File.
Funding Agency:  Physician Initiated
Sub Investigator
November 10, 2005-ongoing

9. A Randomized, Multiple-Dose, Double-Blind, Crossover-Group Comparison of the Safety and Analgesic Efficacy of PMI-150 and Placebo during a Burn Dressing Change (BDC).
Funding Agency:  Javelin Pharmaceuticals
Sub Investigator
Pending 

10. A Randomized Double Blinded Pilot Study Evaluating the Efficacy of Lidoderm 5% Transdermal Patches in Treating Pain in Trauma Patients with Rib and Sternum Fractures
Funding Agency: pending
PI
Pending


PUBLICATIONS:
 

Invited Reviewer


1. Taheri PA, Butz DA, Lottenberg L, et al.  The cost of trauma center readiness.  In Year Book of surgery 2005.  Philadelphia: Mosby Inc; 2005: 32-33. Copeland EM III, et al,


CD-ROM


1. Lottenberg, L, et al.  Patient Management Problems in Trauma and Critical Care, Blunt Chest Trauma.  Ontario: BC Decker; 2003

Journals


1. Carrillo EH, Lottenberg, L, Saridakis A.  Blunt traumatic injury of the gallbladder.  J Trauma. 2004 Aug; 57(2):408-9.


2. Taheri, P, Butz DH, Flint, L, Lottenberg, L, Clawson.  A The cost of trauma center readiness. Am J Surg. 2004 Jan;187(1):7-13.


3. Holtzman RB, Lottenberg L, Bass T, Saridakis A, Carrillo EH.  Comparison of carbon dioxide and iodinated contrast for cavography prior to inferior vena cava filter placement.  Am J Surg. 2003 Apr;185(4):364-8.


4. Block EF, Lottenberg L, Flint L, Jakobsen J, Liebnitzky D.  Use of a human patient simulator for the advanced trauma life support course.  Am.Surg.  2002 Jul;68(7):648-51.


5. Karni A, Holtzman RB, Lottenberg L, et al.  Traumatic head injury in the anticoagulated elderly patient: A lethal combination.  Am. Surg.  2001 Nov;676(11):1098-1100.


6. Stover S, Holtzman RB, Lottenberg L, Bass T.   Blunt inominate injury.  Am.Surg. 2001 Aug;67(8):757-9.


7. Tepas JJ III, Veldenz HC, Lottenberg L, et al. elderly injury: a profile of trauma experience in the sunshine (retirement) state.  J Trauma. 2000 Apr;48(4):581-4.


8. Tola JC, Holtzman RB, Lottenberg L. Bedside placement of inferior vena cava filters in the intensive care unit.  Am Surg. 1999 Sep;65(9):833-7.


9. Bolooki H, Lottenberg L, et al. Myocardial revascularization.  Am J Cardiol, Nov 1975.


10. Bolooki H, Lottenberg L, et al. Myocardial preservation.  Texas Heart Institute Bulletin, Mar 1976.


Abstracts


1. Linda Papa MD, Barbara Orban MD, Celeste Kallenborn RN, Larry Lottenberg MD, Lewis Flint MD.  Assessing effectiveness of a mature trauma system:  Association of proximity to a trauma center with lower injury mortality rate.  Proceedings of the American Association for the Surgery of Trauma Sixty-Fourth Annual Meeting, Atlanta, GA, September 22-24, 2005.


2. Louis Potyondy MD, Lawrence Lottenberg MD, Jonathan Anderson BA, BS, David W. Mozingo MD.  A Case Report of the Use of Hydrogen Peroxide for Achieving Dermal Hemostasis after Burn Excision in a Patient with Platelet Dysfunction.
 

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