Department Name

Lyle L. Moldawer Ph.D.

RESEARCH INTERESTS:

Dr. Moldawer's research interests have focused on the pathophysiologic role of cytokines in the host response to acute and chronic inflammation. For the past 25 years, he has been studying the inflammatory mediators that regulated the metabolic response to injury, particularly the role of interleukin-1 and tumor necrosis factor-alpha in the pathogenesis of the SIRS response.
Dr. Moldawer currently lists 255 peer-reviewed publications. He has received independent funding from the National Institutes of Health (NIH) continuously since 1988. During that period, Dr. Moldawer has pursued the role that dysregulation between proinflammatory cytokine and cytokine inhibitor production plays in the pathologic host response to acute inflammatory processes, such as sepsis and systemic inflammatory response syndromes, and to chronic inflammatory processes, such as cancer and AIDS-associated cachexia. In 1998, Dr. Moldawer received the prestigious Merit Award from the National Institute of General Medical Sciences, extending his current NIH support through the year 2006.
Dr. Moldawer is the principal investigator on a training grant from the NIH to prepare surgical residents in training with a two year research experience in molecular biology and gene therapy. Dr. Moldawer is one of only a small number of Ph.D.'s in the country who holds the academic rank of Full Professor in a Department of Surgery. Since 1988, Dr. Moldawer has trained 28 surgical residents in research methodologies (19 of which at the University of Florida). Sixteen of these surgical residents have continued in academic training programs, and eight are currently on the faculty of colleges of medicine.

Dr. Moldawer is also Co-Director of the Protein Analysis and Cell Biology Core, and a member of the Steering Committee, of a National Institute of General Medical Sciences Large Scale Collaborative Research Program (Glue Grant) entitled, "Inflammation and the Host Response to Injury", funded through 2006 to introduce functional genomics and high throughput proteomics into trauma and sepsis research. 
Dr. Moldawer has sat on or currently sits on the editorial board of five journals, including the American Journal of Physiology, Journal of Parenteral and Enteral Nutrition, Surgical Infections and Shock. He is an Associate Editor of the Journal Shock and American Journal of Physiology, and is Section Editor of Current Opinion in Clinical Nutrition and Metabolic Care. He is a past member of the Metabolic Pathology Study Section of the NIH, and serves on special initial review groups for the National Institute of General Medical Sciences in the fields of graduate medical education, and bum and trauma physiology.

OTHER SUPPORT:

1. R37 GM-40586-14 (NIH/NIGMS)
     08/01/88-11/30/07 $195,190 (direct costs 04-05)
     Lyle L. Moldawer, Ph.D. (Principal Investigator, 25%)
Cytokine Regulation in Sepsis and Inflammation
The overall goal of this award is to examine proinflammatory cytokine, cytokine inhibitor and anti-inflammatory cytokine regulation in sepsis, and bacterial infections.  Using rodent models of a cecal ligationa and puncture, or endotoxemia, the application intends to explore the role of TNF signaling pathways in determining outcome to sepsis and endotoxemic shock.

2. T32 GM-08721-07 (NIH/NIGMS)
     7/1/99-6/30/09 $106,576 (direct costs, 05-06)
     Lyle L. Moldawer, Ph.D. (Principal Investigator, 5%)
Molecular Biology and Gene Therapy in Burns and Trauma
A training grant to provide surgical residents with a two year research experience in the laboratory of an established molecular biologist and gene therapist  M.D. candidates are expected to complete a didactic training program with extensive bench research in the laboratory of a funded basic scientist to develop expertise in molecular biology and gene therapy methodologies.  Opportunities to complete an M.S. degree in clinical science, or a Ph.D. degree are also available.

3. U54 GM-62119-05, (NIH/NIGMS)
     09/30/01-9/29/06 $6,599,869 (direct 01-02)
     Ronald Tompkins, M.D. (Principle Investigator) Lyle Moldawer,Ph.D.
     (Steering Committee, P.I. Proteomics Core, 20%) $195,467 (direct 
     costs 04-05)
Inflammation and the Host Response to Injury
This large scale collaborative project involves 43 investigators nationally, and is aimed at using high throughput genomics and proteomics to determine gene expression and protein expression patterns in trauma and burn patients to identify patients who will succumb to multisystem organ failure.  The Laboratory of Inflammation Biology and Surgical Science serves as the Sample Collection and Coordination Site for the project, as well as an analytical site in the Genomics Core and the Protein Analysis and Cell Biology Cores.  For more information regarding the program, see  www.gluegrant.org.

4. R01 GM-63041-05 (NIH/NIGMS)
      04/01/01-07/31/09  $191,250 (direct costs 05-06)
     Lyle L. Moldawer, Ph.D. (Principal Investigator, 25%)
Targeted Interleukin-10 Gene Therapy in Sepsis Syndromes
This application proposes to explore the utility of adenovirus-based gene therapy as a an anti-inflammatory and anti-apoptotic agent for the treatment of sepsis syndromes.  Two approaches are included.  Targeted expression of anti-inflammatory and anti-apoptotic genes by dendritic cells can alter their phenotype, and dramatically change the interactions between the innate and acquired immune system, through the generation of unique regulatory T-cells.  Targeting dendritic cells both ex vivo and in vivo has become a major focus of the current program.  In addition, by targeting epithelial cells in the liver and lung, adenoviral delivery of anti-inflammatory genes like IL-1 and NF-KB super can alter the balance between pro- and anti-inflammatory cytokines in these local tissue environments.


PUBLICATIONS:

Selected Laboratory Publications in the Past Three Years

318) Scumpia, P.O., Delano, M.J., Kelly, K.M., O'malley, K.A., Efron, P.A., McAuliffe, P.F., Brusko, T., Ungaro, R., Barker, T., Wynn, J.L., Atkinson, M.A., Reeves, W.H., Clare Salzler, M.J., Moldawer, L.L. Increased Natural CD4+CD25+ Regulatory T Cells and Their Suppressor Activity Do Not Contribute to Mortality in Murine Polymicrobial Sepsis. J Immunol. 2006 Dec 1;177(11):7943-9.

317) Matsumoto, T., O'Malley, K., Efron, P.A., Burger, C., McAuliffe, P.F., Scumpia, P.O., Uchida, T., Tschoeke, S.K., Fujita, S., Moldawer, L.L., Hemming, A.W., Foley, D.P. Interleukin-6 and STAT3 protect the liver from hepatic ischemia and reperfusion injury during ischemic preconditioning. Surgery. 2006 Nov;140(5):793-802.

316) Laudanski, K., Miller-Graziano, C., Xiao, W., Mindrinos, M.N., Richards, D.R., De, A., Moldawer, L.L., Maier, R.V., Bankey, P., Baker, H.V., Brownstein, B.H., Cobb, J.P., Calvano, S.E., Davis, R.W., Tompkins, R.G. Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15564-9. Epub 2006 Oct 10.

315) Tsujimoto, H., Ono, S., Matsumoto, A., Kawabata, T., Kinoshita, M., Majima, T., Hiraki, S., Seki, S., Moldawer, L.L., Mochizuki, H. A critical role of CpG motifs in a murine peritonitis model by their binding to highly expressed toll-like receptor-9 on liver NKT cells. J Hepatol. 2006 Sep 22;

314) Tsujimoto, H., Efron, P.A., Matsumoto, T., Ungaro, R.F., Abouhamze, A., Ono, S., Mochizuki, H., Moldawer, L.L. Maturation of murine bone marrow-derived dendritic cells with poly(I:C) produces altered TLR-9 expression and response to CpG DNA. Immunol Lett. 2006 Sep 22.

313) O'malley, K., Moldawer, L.L. Interleukin-6: Still crazy after all these years. Crit Care Med. 2006 Oct;34(10):2690-1.

312) Edwards, C.K. 3rd, Bendele, A.M., Reznikov, L.I., Fantuzzi, G., Chlipala, E.S., Li, L., Moldawer, L.L., Mountz, J.D., Li, Y.Y., Dinarello, C.A. Soluble human p55 and p75 tumor necrosis factor receptors reverse spontaneous arthritis in transgenic mice expressing transmembrane tumor necrosis factor alpha. Arthritis Rheum. 2006 Aug 31;54(9):2872-2885.

311) Sethu, P., Moldawer, L.L., Mindrinos, M.N., Scumpia, P.O., Tannahill, C.L., Wilhelmy, J., Efron, P.A., Brownstein, B.H., Tompkins, R.G., Toner, M. Microfluidic isolation of leukocytes from whole blood for phenotype and gene expression analysis. Anal Chem. 78(15):5453-61. Aug 1, 2006.

310) Moldawer, L.L. What's new in shock, August 2006. Shock. 2006 Aug;26(2):111-4.

309) Moore, F.A., McKinley, B.A., Moore, E.E., Nathens, A.B., West, M., Shapiro, M.B., Bankey, P., Freeman, B., Harbrecht, B.G., Johnson, J.L., Minei, J.P., Maier, R.V. Inflammation and the Host Response to Injury, a Large-Scale Collaborative Project: Patient-Oriented Research Core-Standard Operating Procedures for Clinical Care: III. Guidelines for Shock Resuscitation. J Trauma. 2006 Jul;61(1):82-89.

308) Moldawer, L.L. What's new in shock, june 2006? Shock. 2006 Jun;25(6):555-6.

307) Liu, T., Qian, W.J., Gritsenko, M.A., Xiao, W., Moldawer, L.L., Kaushal, A., Monroe, M.E., Vamum, S.M., Moore, R.J., Purvine, S.O., Maier, R.V., Davis, R.W., Tompkins, R.G., Camp, D.G. 2nd, Smith, R.D. High dynamic range characterization of the trauma patient plasma proteome. Mol Cell Proteomics. 2006 Jun 8.

306) Mathur, A., Baz, M., Staples, E.D., Bonnell, M., Speckman, J.M., Hess, P.J. Jr, Klodell, C.T., Knauf, D.G., Moldawer, L.L., Beaver, T.M.. Cytokine profile after lung transplantation: correlation with allograft injury. Ann Thorac Surg. 2006 May;81(5):1844-50.

305) Tschoeke, S.K., Oberholzer, A., Moldawer, L.L., Interleukin-18: A novel prognostic cytokine in bacteria-induced sepsis. Crit Care Med. 2006 Apr.

304) Tsujimoto, H., Ono, S., Majima, T., Efron, P.A., Kinoshita, M., Hiraide, H., Moldawer, L.L., Mochizuki, H., Differential toll-like receptor expression after ex vivo lipopolysaccharide exposure in patients with sepsis and following surgical stress. Clin Immunol. 2006 Mar 3.

303) Oberholzer, C., Tschoeke, S.K., Moldawer, L.L., Oberholzer, A. Local thymic caspase-9 inhibition improves survival during polymicrobial sepsis in mice. J Mol Med. 2006 Feb 2;:1-7.

302) Delano, M.J., Moldawer, L.L., The origins of cachexia in acute and chronic inflammatory diseases. Nutr Clin Pract. 2006 Feb;21(1):68-81.

301) Marshall, J.C., Deitch, E., Moldawer, L.L., Opal, S., Redl, H., Poll, T.V.. PRECLINICAL MODELS OF SHOCK AND SEPSIS: WHAT CAN THEY TELL US? Shock. 2005 Dec;24 Suppl 1:1-6.

300) Moldawer, L.L.. WHAT'S NEW IN Shock, January 2006? Shock. 2006 Jan;25(1):1-3.

299) McAuliffe, P.F., Efron, P.A., Scumpia, P.O., Uchida, T., Mutschlecner, S.C., Rout, W.R., Moldawer, L.L., Cendan, J.C.. Varying blood monocyte and dendritic cell responses after laparoscopic versus open gastric bypass surgery. Obes Surg. 2005 Nov-Dec;15(10):1424-31.

298) Scumpia, P.O., Moldawer, L.L.. Biology of interleukin-10 and its regulatory roles in sepsis syndromes. Crit Care Med. 2005 Dec;33(12 Suppl):S468-S471.

297) Calvano, S.E., Xiao, W., Richards, D.R., Felciano, R.M., Baker, H.V., Cho, R.J., Chen, R.O., Brownstein, B.H., Cobb, J.P., Tschoeke, S.K., Miller-Graziano, C., Moldawer, L.L., Mindrinos, M.N., Davis, R.W., Tompkins, R.G., Lowry, S.F., Bankey, P.E., Billiar, T.R., Camp, D.G., Casella, G., Chaudry, I.H., Choudhry, M.A., Cooper, C., De, A., Elson, C., Freeman, B., Gamelli, R.L., Campbell-Finnerty, C., Gibran, N.S., Hayden, D.L., Harbrecht, B.G., Herndon, D.N., Horton, J.W., Hubbard, W.J., Hunt, J.L., Johnson, J., Klein, M.B., Lederer, J.A., Logvinenko, T., Maier, R.V., Mannick, J.A., Mason, P.H., McKinley, B.A., Minei, J.P., Moore, E.E., Moore, F.A., Nathens, A.B., O'keefe, G.E., Rahme, L.G., Remick, D.G., Schoenfeld, D.A., Schwacha, M.G., Shapiro, M.B., Silver, G.M., Smith, R.D., Storey, J.D., Toner, M., Warren, H.S., West, M.A.. Corrigendum: A network-based analysis of systemic inflammation in humans. Nature. 2005 Dec 1;438(7068):696.

296) Schreiber, J., Efron, P.A., Park, J.E., Moldawer, L.L., Barbul, A. Adenoviral gene transfer of an NF-kappaB super-repressor increases collagen deposition in rodent cutaneous wound healing. Surgery. 2005 Nov;138(5):940-946.

295) McAuliffe, P.F., Murday, M.E., Efron, P.A., Scumpia, P.O., Ungaro, R., Abouhamze, A., Tannahill, C.L., Hutchins, B., Laface, D., Moldawer, L.L. Dose-dependent improvements in outcome with adenoviral expression of interleukin-10 in a murine model of multisystem organ failure. Gene Ther. 2005 Oct 27.

294) Feezor, R.J., Cheng, A., Paddock, H.N., Baker, H.V., Moldawer, L.L. Functional genomics and gene expression profiling in sepsis: beyond class prediction. Clin Infect Dis. 2005 Nov 15;41 Suppl 7:S427-35.

293) De, A.K., Miller-Graziano, C.L., Calvano, S.E., Laudanski, K., Lowry, S.F., Moldawer, L.L., Remick, D.G. Jr., Rajicic, N., Schoenfeld, D., Tompkins, RG. Selective activation of peripheral blood T cell subsets by endotoxin infusion in healthy human subjects corresponds to differential chemokine activation. J Immunol. 2005 Nov 1;175(9):6155-62.

292) Calvano, S.E., Xiao, W., Richards, D.R., Felciano, R.M., Baker, H.V., Cho, R.J., Chen, R.O., Brownstein, B.H., Cobb, J.P., Tschoeke, S.K., Miller-Graziano, C., Moldawer, L.L., Mindrinos, M.N., Davis, R.W., Tompkins, R.G., Lowry, S.F., Large Scale Collab Res Program IA. Abstract A network-based analysis of systemic inflammation in humans. Nature. 2005 August 31.

291) Scumpia, P.O., McAuliffe, P.F., O'malley, K.A., Ungaro, R., Uchida, T., Matsumoto, T., Remick, D.G., Clare-Salzler, M.J., Moldawer, L.L., Efron, P.A. CD11c+ Dendritic Cells Are Required for Survival in Murine Polymicrobial Sepsis. J Immunol. 2005 Sep 1;175(5):3282-6.

290) Tsujimoto, H., Uchida, T., Efron, P.A., Scumpia, P.O., Verma, A., Matsumoto, T., Tschoeke, S.K., Ungaro, R.F., Ono, S., Seki, S., Clare-Salzler, M.J., Baker, H.V., Mochizuki, H., Ramphal, R., Moldawer, L.L. Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactions. J Leukoc Biol. 2005 Oct;78(4):888-97.

289) Biberthaler, P., Bogner, V., Baker, H.V., Lopez, M.C., Neth, P., Kanz, K., Mutschler, W., Jochum, M., Moldawer, L.L. Genome-wide monocytic mRNA Expression in Polytrauma Patients for Identification of Clinical Outcome. Shock. 2005 Jul;24(1):11-19.

288) Efron, P.A., Tsujimoto, H., Bahjat, F.R., Ungaro, R., Debernardis, J., Tannahill, C., Baker, H.V., Edwards, C.K., Moldawer, L.L. Differential Maturation of Murine Bone-Marrow Derived Dendritic Cells with Lipopolysaccharide and Tumor Necrosis Factor-a. J Endotoxin Res. 2005;11(3):145-60.

287) Litherland, S.A., Xie, T.X., Grebe, K.M., Davoodi-Semiromi, A., Elf, J., Belkin, N.S., Moldawer, L.L., Clare-Salzer, M.J.Signal transduction activator of transcription 5 (STAT5) dysfunction in autoimmune monocytes and macrophages. J Autoimmun. 2005 Jun;24(4):297-310. Epub 2005 Mar 23.

286) Oberholzer, A., Oberholzer, C., Efron, P., Bahjat, K., Ungaro, R., Tannahill, C., Murday, M., Bahjat, F., Tsai, V., Hutchins, B., Moldawer, L.L., LaFace, D., Clare-Salzler, M. Functional modification of dendritic cells with recombinant adenovirus encoding IL-10 for the treatment of sepsis. Shock. 2005 Jun;23(6);507-15.

285) Oberholzer, A., Souza, S.M., Tschoeke, S.K., Oberholzer, C., Abouhamze, A., Pribble, J.P., Moldawer, L.L. Plasma cytokine measurements augment prognostic scores as indicators of outcome in patients with severe sepsis. Shock. 2005 Jun;23(6):488-93.

284) Oberholzer, C., Tschoeke, S.K., Bahjat, K., LaFace. D., Hutchins, B., Clare-Salzler, M.J., Moldawer, L.L., Oberholzer, A. In vivo transduction of thymic dendritic cells with adenovirus and its potential use in acute inflammatory diseases. Scand J Immunol. 2005 Apr; 61(4):309-15.

283) Lainee P, Efron P, Tschoeke SK, Elies L, de Winter H, Lorre K, Moldawer LL. Delayed Neutralization of Interferon-y Prevents Lethality in Primate Gram Negative Bacteremic Shock. Crit Care Med Apr;33(4):797-805, 2005.

282) Cobb, J.P., Mindrinos, M.N., Miller-Graziano, C., Calvano, S.E., Baker, H.V., Xiao, W., Laudanski, K., Brownstein, B.H., Elson, C.M., Hayden, D.L., Herndon, D.N., Lowry, S.F., Maier, R.V., Schoenfeld, D.A., Moldawer, L.L., Davis, R.W., Tompkins, R.G., Baker, H.V., Bankey, P., Billiar, T., Brownstein, B.H., Calvano, S.E., Camp, D., Chaudry. I., Cobb, J.P., Davis, R.W., Elson, C.M., Freeman, B., Gamelli, R., Gibran, N., Harbrecht, B., Hayden, D.L., Heagy, W., Heimbach, D., Herndon, D.N., Horton, J., Hunt, J., Laudanski, K., Lederer, J., Lowry, S.F., Maier, R.V., Mannick, J., McKinley, B., Miller-Graziano, C., Mindrinos, M.N., Minei, J., Moldawer, L.L., Moore, E., Moore, F., Munford, R., Nathens, A., O'keefe, G., Purdue, G., Rahme, L., Remick, D., Sailors, M., Schoenfeld, D.A., Shapiro, M., Silver, G., Smith, R., Stephanopoulos, G., Stormo, G., Tompkins, R.G., Toner, M., Warren, S., West, M., Wolfe, S., Xiao, W., Young, V. Application of genome-wide expression analysis to human health and disease. Proc Natl Acad Sci U S A Mar 29;102(13):4801-6, 2005. Epub 2005 Mar 21.

281) Qian, W.J., Monroe, M.E., Liu, T., Jacobs, J.M., Anderson, G.A., Shen, Y., Moore, R.J., Anderson, D.J., Zhang, R., Calvano, S.E., Lowry, S.F., Xiao, W., Moldawer, L.L., Davis, R.W., Tompkins, R.G., Camp, D.G. 2nd, Smith, R.D. Quantitative proteome analysis of human plasma following in vivo lipopolysaccharide administration using 16O/18O labeling and the accurate mass and time tag approach. Mol Cell Proteomics 2005 Mar 7

280) Tschoeke, S.K., Moldawer, L.L. Human leukocyte antigen expression in sepsis: what have we learned? Crit Care Med Jan;33(1):236-7,2005.

279) Qian, W.J., Jacobs, J.M., Camp, D.G. 2nd, Monroe, M.E., Moore, R.J., Gritsenko, M.A., Calvano, S.E., Lowry, S.F., Xiao, W., Moldawer, L.L., Davis, R.W., Tompkins, R.G., Smith, R.D. Comparative proteome analyses of human plasma following in vivo lipopolysaccharide administration using multidimensional separations coupled with tandem mass spectrometry. Proteomics Feb;5(2):572-84, 2005.

278) Tsujimoto, H., Ono, S., Majima, T., Kawarabayashi, N., Takayama, E., Kinoshita, M., Seki, S., Hiraide, H., Moldawer, L.L., Mochizuki, H. Neutrophil elastase, MIP-2, and TLR-4 expression during human and experimental sepsis. Shock Jan;23(1):39-44, 2004.

277) Oberholzer, C., Oberholzer, A., Tschoeke, S.K., Minter, R.M., Bahjat, F.R., LaFace, D., Hutchins, B., Moldawer, L.L. Influence of recombinant adenovirus on liver injury in endotoxicosis and its modulation by IL-10 expression. J Endotoxin Res 10(6):393-401, 2004.

276) Matsumoto, T., Efron, P.A., Tsujimoto, H., Tschoeke, S.K., Ungaro, R., Fujita, S., Foley, D.P., Hemming, A., Moldawer, L.L. Splenic transposition is superior to caudal shunt as a model of murine total hepatic ischemia. Lab Invest Nov 22; 2004.

275) Feezor, R.J., Baker, H.V., Mindrinos, M., Hayden, D., Tannahill, C.L., Brownstein, B.H., Fay, A., MacMillan, S., Laramie, J., Xiao, W., Moldawer, L.L., Cobb, J.P., Laudanski, K., Miller-Graziano, C.L., Maier, R.V., Schoenfeld, D., Davis, R.W., Tompkins, R.G., and the Inflammation and Host Response to Injury Large Scale Collaborative Research Program. Whole Blood and Leukocyte RNA Isolation for Gene Expression Analyses. Physiological Genomics Nov;19:(3);247-54, 2004.

274) Chao, T.H., Lam, T., Vong, B.G., Traves, P.G., Hortelano, S., Chowdhury, C., Bahjat, F.R., Lloyd, G.K., Moldawer, L.L., Bosca, L., Palladino, M.A., Theodorakis, E.A. A New Family of Synthetic Diterpenes that Regulates Cytokine Synthesis by Inhibiting IkappaBalpha Phosphorylation. Chembiochem Nov 12, 2004.

273) Sethu, P., Anahtar, M., Moldawer, L.L., Tompkins, R.G., Toner, M. Continuous flow microfluidic device for rapid erythrocyte lysis. Anal Chem Nov 1;76(21):6247-53, 2004.

272) Minnich, D.J., Moldawer, L.L. Anti-cytokine and anti-inflammatory therapies for the treatment of severe sepsis: progress and pitfalls. Proc Nutr Soc Aug;63(3):437-41, 2004.

271) Oldenburg, H.S., Siroen, M.P., Boelens, P.G., Sluijter, B.J., Pruitt, J.H., Naseri, A.H., Rauwerda, J.A., Meijer, S., Cuesta, M.A., van Leeuwen, P.A., Moldawer, L.L. Aortic aneurysm repair is associated with a lower inflammatory response compared with surgery for inflammatory bowel disease. Eur Surg Res Sep-Oct;36(5):266-73, 2004.

270) Efron PA, Martins A, Minnich D, Tinsley K, Ungaro R, Bahjat FR, Hotchkiss R, Clare-Salzler M, Moldawer LL. Characterization of the Systemic Loss of Dendritic Cells in Murine Lymph Nodes During Polymicrobial Sepsis. J of Immunology Sep;173(5):3035-43, 2004.

269) Camp, E.R., Li, J., Minnich, D.J., Brank, A., Moldawer, L.L., MacKay, S.L., Hochwald, S.N. Inducible nuclear factor-kappaB activation contributes to chemotherapy resistance in gastric cancer. J Am Coll Surg Aug;199(2):249-58, 2004.

268) Voboril R, Hochwald SN, Li J, Brank A, Weberova J, Wessels F, Moldawer LL, Ramsay Camp E, MacKay SL. Inhibition of NF-Kappa B augments sensitivity to 5-Fluotouracil/Folinic acid in colon cancer (1). J Surg Res. 2004 Aug;120(2):178-88

267) Reinhart K, Gluck T, Ligtenberg J, Tschaikowsky K, Bruining A, Bakker J, Opal S, Moldawer LL, Axtelle T, Turner T, Souza S, Pribble J. CD14 receptor occupancy in severe sepsis: results of a phase I clinical trial with a recombinant chimeric CD14 monoclonal antibody (IC14). Crit Care Med. 2004 May;32(5):1100-8.

266) Feezor R.J., Baker H.V., Wenzhong X., Lee W.A., Huber T.S., Mindrinos M., Kim R.A., Ruiz-Taylor L., Moldawer L.L., Davis R.W., Seeger J.M. Genomic and proteomic determinants of outcome in patients undergoing thoracoabdominal aortic aneurysm repair. The Journal of Immunology. June ;172(11):7103-9, 2004.

265) Efron P.A., Tinsley K., Minnich D.J., Monterroso V., Wagner J., Lain e P., Lorr K., Swanson P.E., Hotchkiss R., Moldawer L.L. Increased lymphoid tissue apoptosis in baboons with bacteremic shock. Shock, June;21(6):566-571, 2004.

264) Blenman K.R., Bahjat F.R., Moldawer L.L., Morel L. Aberrant signaling in the TNFalpha/TNF receptor 1 pathway of the NZM2410 lupus-prone mouse.  Clin Immunol. Feb;110(2):124-33, 2004.

263) Litherland S.A., Xie T.X., Grebe K.M., Li Y., Moldawer L.L., Clare-Salzler M.J. IL10 resistant PGS2 expression in at-risk/Type 1 diabetic human monocytes. J Autoimmun. May;22(3):227-33, 2004.

262) Schottelius A.J., Moldawer L.L., Dinarello C.A., Asadullah K., Sterry W., Edwards C.K. 3rd. Biology of tumor necrosis factor-alpha- implications for psoriasis. Exp Dermatol. Apr;13(4):193-222, 2004.

261) Efron P.A., Moldawer L.L. Cytokines and wound healing: the role of cytokine and anticytokine therapy in the repair response. J Burn Care Rehabil. Mar-Apr;25(2):149-60, 2004.

260) Feezor, R.J., Paddock, H.N., Baker, H.V., Varela, J.C., Barreda, J., Moldawer, L.L., Schultz, G.S., Mozingo, D.W. Temporal patterns of gene expression in murine cutaneous burn wound healing. Physiol Genomics. 16(3):341-8, 2004.

259) Paddock, HN., Schultz, G.S., Baker, H.V., Varela, J.C., Beierle, E.A., Moldawer, L.L., Mozingo, D.W. Analysis of gene expression patterns in human postburn hypertrophic scars. J Burn Care Rehabil 24(6):371-7, 2003.

252) Sarcia P.J., Scumpia P.O., Moldawer L.L., DeMarco V.G., Skimming J.W. Hypothermia induces interleukin-10 and attenuates injury in the lungs of endotoxemic rats. Shock 20(1):41-5, 2003.

251) Welborn M.B. 3rd, Moldawer L.L., Seeger J.M., Minter R.M., Huber T.S. Role of endogenous interleukin-10 in local and distant organ injury after visceral ischemia-reperfusion. Shock 20(1):35-40, 2003.

250) Li J., Kokkola R., Tabibzadeh S., Yang R., Ochani M., Qiang X., Harris H.E., Czura C.J., Wang H., Ulloa L., Wang H., Warren H.S., Moldawer L.L., Fink M.P., Andersson U., Tracey K.J., Yang H. Structural basis for the proinflammatory cytokine activity of high mobility group box 1. Mol Med 9(1-2):37-45, 2003.

249) Hochwald S.N., Lind D.S., Malaty J., Copeland E.M. 3rd, Moldawer L.L., MacKay S.L. Antineoplastic therapy in colorectal cancer through proteasome inhibition. Am Surg 69(1):15-23, 2003.