Transplantation / Hepatobiliary Surgery

 

Alan I. Reed
M.D.

RESEARCH INTERESTS:

Dr. Reed's research is clinically based. His association with Dr. Elizabeth Shankman in the Department of Epidemiology and Health Policy Research has lead to three new IRB proposals on outcomes measurements of various kinds following liver transplantation. The first two have been approved. The first is a liver transplant database that will allow the collection of critical information on liver transplant recipients for later study. The second is a a financial analysis to see whether the MELD allocation system is predictive of transplant case cost and to determine whether a formula for the prediction of case cost can be derived. The third, pending approval, regards the clinical efficacy and cost effectiveness of an anti-fungal prophylaxis regimen in liver transplant patients. His project on liver re-transplantation was accepted for publication in Transplantation Proceedings. Dr. Reed is also working on a third project (IRB approved) that fits into the 3-D reconstruction effort. This project compares the use of 3-D stereoscopic imaging to standard 3-D reconstruction with respect to identifying the anatomy of renal donors (LRD's).

SUPPORT:

1. Reed A, Fujita SP, Hemming AW, Foley DP, Liver Database Project, Enzon Pharmaceuticals, unrestricted grant, $10,000, PI.

2. A One-Year, Multicenter, Open-Label, Randomized Study to Evaluate the Safety and the Efficacy of FTY720 Combined with Tacrolimus and Steroids Versus MMF (CellCept) Combined with Tacrolimus and Steroids, in de novo Adult Renal Transplant Recipients. Kaplan B, Meier-Kriesche HU, Srinivas TR, Howard RJ, Fujita S, Reed A, Hemming A, Foley D, Patton PR , Bucci M, Eagan A, Lewis K, Womer K. Novartis, 2004.

3. Open Label, Prospective, Randomized, Controlled, Multi-Center Study Assessing Fixed Dose vs Concentration Controlled CellCept Regimans for Patients FollowingA Single Organ Renal Transplantation in Combination with Full Dose and Reduced Dose Calcineurin Inhibitors. Kaplan B, Meier-Kriesche HU, Srinivas TR, Howard RJ, Fujita S, Reed A, Hemming A, Foley D, Patton PR , Bucci M, Eagan A, Lewis K, Womer K. Roche Laboratories, 2004.

PUBLICATIONS:


Refereed Publications:

1. Reed A, Hemming AW, Howard RJ, Fujita SP, Foley DP, Langham MR, Schold JD, Nelson D, Soldevila-Pico C, Abdelmalek M, Firpi R, Morelli G, Liver Re-Transplantation: A Single Center Outcome and Financial Analysis, Transplantation Proceedings, (accepted for publication)

2. Formea CM, Myers H, Wu R, Crabtree J, Silkensen J, Howard RJ, Reed A, Karlix J, et.al., Thiopurine S-Methyl Transferase Genotype Predicts Azathioprine Induced Myelotoxicity in Kidney Transplant Recipients; American Journal of Transplantation, (Accepted for Publication)

3. Firpi RJ, Abdelmalek MF, Soldevila-Pico C, Cabrera R, Schuster JJ, Theriaque D, Reed A, Hemming AW, Liu C, Crawford JM, Nelson DR et.al., One year protocol Liver Biopsy Can Stratify Fibrosis Progression In Liver Transplant Recipients with Recurrent Hepatitis C Infection, Liver Transplantation, (Accepted for Publication)

4. Meier-Krieshe H-U, Schold J, Srinivas T, Reed A, Kaplan B, Kidney Transplant Halts Cardiovascular Disease Progression in Patients with End Stage Renal Disease, American Journal of Transplantation, (Accepted for Publication)

5. Ehlers SL, Rodrigue JR, Windows, MR, Reed, AI, Nelson, DR. Tobacco Use Before and After Liver Transplantation: A Single Center Survey and Implications for Clinical Practice and Research. Liver Transplantation 10 (3), March 2004, 412-417

6. Abdelmalek MF, Firpi RJ, Soldevila-Pico C, Reed A, Hemming AW, Liu C, Crawford JM, Davis GL, Nelson DR, Sustained Viral Response to Interferon and Ribavirin in Liver Transplant Recipients with Recurrent Hepatitis C, Liver Transplantation, Vol 10, No 2 (February) 2004, 199-207

7. Hemming AW, Reed AI, Howard RJ, Fujita S, Hochwald SN, Caridi JG, Hawkins IF, Vauthey J-N, Preoperative Portal Vein Embolization for Extended Hepatectomy, Annals of Surgery, 237 (5), 686-93, May 2003

8. Hemming AW, Reed AI, Langham MR, Fujita S, van der Werf WJ, Howard RJ, Hepatic Vein Reconstruction for Resection of Hepatic Tumors, Annals of Surgery, Vol 235, No 6, 2002, 850-858

9. Howard RJ, Patton PR, Reed AI, Hemming AW, van derWerf WJ, Pfaff WW, Srinivas TR, Scornik JC, The Changing Causes of Graft Loss and Death After Kidney Transplantation, Transplantation, Vol 73, No 12, June 27, 2002, 1923-1928

10. Howard RJ, Thai VB, Patton P, Hemming AW, Reed AI, Van der Werf WJ, Fujita S, Karlix JL, Scornik Juan. Obesity Dose not Portend a Bad Outcome for Kidney Transplant Recipients. Transplantation 73 (1): 53-55, January 2002

11. Nelson DR, Soldevila-Pico C, Reed A, Abdelmalek MF, Hemming AW, Van der Werf WJ, Howard R, Davis GL. Anti-interleukin-2 Receptor Therapy in Combination with Mycophenolate Mofetil is Associated with More Severe Hepatitis C Recurrence After Liver Transplantation. Liver Transplantation 7 (12): 1064-1070, December 2001

12. Howard RJ, Reed AI, Hemming AW, Van der Werf WJ, Patton PR, Pfaff WW, Srinivas TR, Scornik JC. Graft Loss and Death: Changing Causes after Kidney Transplantation. Transplantation Proceedings 33 (7-8): 3416, November-December 2001

13. Hemming AW, Langham MR, Reed A, Van der Werf WJ, Howard RJ. Resection of the Inferior Vena Cava for Hepatic Malignancy. American Surgeon 67(11): 1081-1087, November 2001

14. Langham MR, Tzakis AG, Gonzalez-Peralta, R, Thompson JF, Rosen CB, Nery JR, Reed AI, Ruiz P, van derWerf, WJ, Hemming AW, Howard RJ, Graft Survival in Pediatric Liver Transplantation, Journal of Pediatric Surgery, Vol 36, No 8 (August), 2001, 1205-1209

15. Howard RJ, Reed AI, Van der Werf WJ, Hemming AW, Patton PR, Scornik JC. What Happens to Renal Transplant Recipients Who Lose Their Grafts? American Journal of Kidney Diseases 38 (1): 31-35, July 2001.

16. Hemming AW, Cattral MS, Reed AI, Van der Werf WJ, Greig PD, Howard RJ. Liver Transplantation for Hepatocellular Carcinoma. Annals of Surgery 233(5): 652-659, May 2001

17. Scornik JC, Soldevilla-Pico C, van derWerf WJ, Hemming AW, Reed AI, Langham MR, Howard RJ, Susceptibility of Liver Allografts to High or Low Concentrations of Preformed Antibodies as Measured by Flow Cytometry, American Journal of Transplantation, Vol 1, 2001, 152-156

18. Scornik, JC, Clapp W, Patton PR, van derWerf WJ, Hemming AW, Reed AI, Howard RJ, Outcome of Kidney Transplants in Patients known to be Flow Cytometry Crossmatch Positive, Transplantation, Vol 71, No 8, April 27, 2001, 1098-1102

19. Scornik JC, Lauwers GL, Reed AI, Howard RJ, Dickson RC, Rosen CB. Infusion of Donor Spleen Cells and Rejection in Liver Transplant Recipients. Clinical Transplantation 14:55-60, 2000

20. Howard RJ, Reed AI, Van der Werf WJ, Silkensen JA, Patton PR, Scornik JC. Development of Polycystic Disease in a Kidney 10 Years After Transplantation. Transplantation 68(10): 1620, November 1999.

Non-refereed Publications:

1. Fujita S, Hemming, AW, Reed A, Howard RJ, Nelson D, Liu C, Mergo P, Combined Hepatic Resection and Radiofrequency Ablation for Multiple Hepatic Adenomas, Journal of Gastroenterology and Hepatology (accepted for publication)

2. Lisson, G.L., Rodrigue, J.R., Reed, A.I., & Nelson, D.R., A Brief Psychological Intervention to Improve Adherence Following Transplantation, Annals of Transplantation, (accepted for publication)

3. Rodrigue JR, Cornell DL, Jackson SI, Kanasky W, Marhefka S, Reed AI, Are Organ Donation Attitudes and Beliefs, Empathy, and Life Orientation Related to Donor Registration Status, Progress In Transplantation, Vol 14, No 1, 56-61, March 2004

4. Hemming AW, Langham MR, Reed AI, van derWerf WJ, Howard RJ, Resection of the Inferior Vena Cava for Hepatic Malignancy, The American Surgeon, Vol 67, November 2001, 1081-1088

BOOKS/CHAPTERS:

1. Reed A, Baz M McGinn L, Schofield R, Solid Organ Transplantation, in Biopsychosocial Perspectives on Transplantation, James Rodrigue, editor, Kluwer Academic/Plenum Publishers, New York, 2001, 1-19

2. D'Alessandro AM, Knechtle SJ, Reed A, Fields BL, Sollinger HW, Pirsch JD, Kalayoglu M, Belzer FO. Immunosuppression in Solid Organ Transplantation. In Fuhrman BP and Zimmerman JJ, (eds): Pediatric Critical Care, St. Louis, Missouri, 1992, CV Mosby, pp. 951-964

3. Pirsch JD, D'Alessandro AM, Sollinger HW, Voss BJ, Knechtle SJ, Reed A, Kalayoglu M, Belzer FO. Living-Unrelated Renal Transplantation at the University of Wisconsin. In: Clinical Transplants 1990, P.I. Terasaki, (ed.): 241-245, 1991

4. D'Alessandro AM, Lorentzen DF, Pirsch JD, Knechtle SJ, Reed A, Hoffmann RM, Armbrust MJ, Sollinger HW, Kalayoglu M, Belzer FO: Cadaveric Renal Transplantation in the Cyclosporine and OKT3 Eras: An Update of the University of Wisconsin-Madison Experience. In: Clinical Transplants 1989, P.I. Terasaki, (ed.): 239-251, 1990

REVIEWS:

1. Hemming AW, Nelson DR, Reed AI. Liver Transplantation for Hepatocellular Carcinoma. Minerva Chir 57(5): 575-585, October 2002

MISCELLANEOUS:

1. Hemming AW and Reed A, Left Trisegmentectomy with Reconstruction of the Segment Six Hepatic Vein, 2004 meeting of the American Hepato Pancreato Biliary Association, Video Presentation, 2003

 

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