Vascular Surgery

 
James M. Seeger
M.D.

RESEARCH INTERESTS:

Dr. Seeger's research activities have been a combination of clinical and translational research, with these latter studies having evolved from previous more basic work. In addition, all of his research interests are directly related to the management of various aspects of peripheral arterial disease. In the area of aortic surgery, he has been interested for several years in the postoperative inflammatory response associated with major aortic reconstruction and the role of this inflammatory response in the development of single and multiorgan failure after aortic repair. Working with Dr. Moldawer's laboratory, Dr. Seeger and his associates have demonstrated the relationship between this inflammatory response and the development of postoperative complications, have identified mesenteric ischemia, particularly associated with thoracoabdominal aorta aneurysm repair, as being a primary factor in the development of this inflammatory response, and more recently have identified circulating white cell gene profiles that may be class predictors for patients who develop single and multiorgan failure after major aortic reconstruction. In the area of the management of patients with peripheral arterial occlusive disease, Dr. Seeger has investigated various aspects of the management of chronic mesenteric ischemia and clinical outcome after treatment of severe arterial occlusive disease associated with limb-threatening ischemia and identified several adjuncts to distal bypass to improve initial and long term graft patency and limb salvage. Finally, past investigations, in conjunction with the Center for Biomaterials in the College of Engineering sought to develop new techniques for use of endovascular stents for drug delivery. This work led to several new stent coating techniques and several patents, but currently is inactive. 

SUPPORT:

1. North American Symptomatic Carotid Endarterectomy Trial (NASCET). NIH Funded Multicenter Clinical Trial, $80,000 (7/1991 - 1/1998), Principal Investigator

2. Trial of Surgery and Thrombolysis for ischemia of the lower extremity (STILE study). Genetect, Inc. $120,000 (8/1991 - 6/1994), Principal Investigator

3. ASA and Carotid Endarterectomy (ACE). McMaster University, $11,000 (8/1994 - 5/1998), Principal Investigator

4. A prospective evaluation of the Boston Scientific Vascular Endoprosthesis for Elective Treatment of Infrarenal abdominal aortic aneurysms and aortoiliac aneurysms in humans. Boston Scientific/ MediTech, $146,152 (4/1997 - present), Principal Investigator

5. A Clinical Study Comparing Use of the Thoracic EXCLUDER Endoprosthesis to Open Surgical Repair in the Primary Treatement of Descending Thoracic Aneurysms. W.L. Gore & Associates, Inc., $235,937 (3/2000 - present), Co-Principal Investigator

6. Evaluation of Intimal Hyperplasia and Healing for Dexamethasone Loaded Silicone Coated Dacron vascular Prostheses in an Arteriovenous Canine Shunt Model in vivo. Biomedical Engineering Program Seed Project, University of Florida. $9,525 (10/19/1998 - 04/30/1999), Principal Investigator 

7. Evaluation of Intimal Hyperplasia and Healing for Dexamethasone Loaded Silicone Coated Dacron Vascular Prostheses." Impra of C. R. Bard Inc., $6,000 (2000-2001), Principal Investigator 

8. Safety and Tolerance of Intravenous rHulL-10 in Patients Undergoing Elective Thoracoabdominal Aortic Aneurysm Repair. Schering Plough Research Institute, $81,850 (8/1997 - 11/1999), Principal Investigator

PUBLICATIONS:

1. Rectenwald JE, Huber TS, Moldawer LL, Seeger JM, Ozaki CK. Membrane bound TNF-a mediates neointimal hyperplasia. Surgical Forum 1999;50:460-462.

2. Gaines GC, Welborn MB, Moldawer LL, Huber TS, Harward TR, Seeger JM, Attenuation of Skeletal muscle Ischemia/Reperfusion Injury by Inhibition of Tumor Necrosis Factor. J Vasc Surg 1999;29(2):370-376.

3. Ozaki CK, Irwin PB, Flynn TC, Huber TS, Seeger JM. Surgical Decision making for Carotid Endarterectomy and Contemporary Magnetic Resonance Angiography. Am J Surg 1999;178:182-184.

4. Seeger JM, Back MR, Albright JL, Carlton LM, Harward TR, Kubulis PS, Flynn TC, Huber TS. Influence of Patient Characteristics and Treatment Options on Outcome of Patients with Prosthetic Aortic Graft Infection. Ann Vasc Surg 1999;13(4):413-420.

5. Seeger JM, Pretus HA, Carlton LC, Flynn TC, Ozaki CK, Huber TS. Potential predictors of outcome in patients with tissue loss who undergo infrainguinal vein bypass grafting. J Vasc Surg 1999 Sep;30(3):427-35.

6. Huber TS, Flynn, TC, Ozaki CK, Seeger JM. Utility of Laparoscopy for Identification of Hepatic Disease before Aortic Surgery. Vascular Surgery 1999;33:471-479.

7. Huber TS, Wang JG, Wheeler KG, Cuddeback JK, Flynn TC, Seeger JM. Impact of race on the treatment for peripheral arterial occlusive disease. J Vasc Surg 1999 Sep;30(3):417-26.

8. Rectenwald JE, Minter RM, Moldawer LL, Huber TS, Seeger JM, Ozaki CK. Direct in vivo evidence for TNF modulation of neointimal hyperplasia. Circulation 2000;102:1697-1702.

9. Huber TS, Ozaki CK, Flynn TC, Ross EA, Seeger JM. Use of superficial femoral vein for hemodialysis arteriovenous access. J Vasc Surg 2000 May;31(5):1038-41.

10. Huber TS, Carlton LM, O'Hern DG, Ozaki CK, Flynn TC, Seeger JM. Financial impact of tertiary care in an academic medical center. Ann Surg 2000 Jun;231(6):860-8.

11. Huber TS, Gaines GC, Welborn MB 3rd, Rosenberg JJ, Seeger JM, Moldawer LL. Anticytokine therapies for acute inflammation and the systemic inflammatory response syndrome: IL-10 and ischemia/reperfusion injury as a new paradigm. Shock 2000 Jun;13(6):425-34. 

12. Welborn MB, Hess PJ, Oldenburg HSA, Huber TS, Martin TD, Rauwerda JA, Wesdorp RIC, Copeland EM, Moldawer LL, Seeger JM. The relationship between visceral ischemia, proinflammatory cytokines and organ injury in patients undergoing thoracoabdominal aortic aneurysm repair. Crit Care Med 2000;28(9):3191-7.

13. Oldenburg HS, Welborn MB, Pruitt JH, Boelens PG, Seeger JM, Martin TD, Wesdorp RI, Rauwerda JA, van Leeuwen PA, Moldawer LL. Interleukin-10 Appearance Following Thoraco-abdominal and Abdominal Aortic Aneurysm Repair is Associated with the Duration of Visceral Ischaemia. Eur J Vasc Endovasc Surg 2000 Aug;20(2):169-172. 

14. Back MR, Sarac TP, Modawer LL, Seeger JM, Huber TS. Laparotomy prevents lethal endotoxemia in a murine thoracoabdominal aneurysm repair model by an IL-10 dependent mechanism. Shock 2000;14:157-162.

15. Welborn MB, Abouhamze A, Ozaki CK, Huber TS, Seeger JM, Moldawer LL. The p50 subunit of NFB inhibits LPS induced TNF production but not LPS tolerance in vivo. Journal of Experimental Medicine. Submitted

16. Back MR, Kluess HA, Huber TS, Stopka CB, Scott KN, Ballinger JR, Bruner AP, Lyles T, Harward TRS, Seeger JM. Evaluation of skeletal muscle metabolic responses following exercise training in patients with intermittent claudicaiton. Vasc Surg 2000;34(4):345-359.

17. Derrow AE, Seeger JM, Dame DA, Carter RL, Ozaki CK, Flynn TC, Huber TS. The outcome in the United States after thoracoabdominal aortic aneurysm repair, renal artery bypass, and mesenteric revascularization. J Vasc Surg 2001;34:54-61.

18. Rectenwald JE, Pretus HA, Seeger JM, et al. External-Beam radiation therapy for improved dialysis access patency: Feasibility and early safety. Radiation Research 2001;156:53-60.

19. Huber TS, Wang JG, Derrow AE, Dame DA, Ozaki CK, Zelenock GB, Flynn TC, Seeger JM. Experience in the United States with intact abdominal aortic aneurysm repair. J Vasc Surg 2001;33(2):304-311.

20. Abela GS, Hage-Korban E, Tomaru T, Barbeu GR, Friedl SE, Kaelin LD, Seeger JM. A model for evaluation of arterial thrombosis following interventional procedures. Lasers Med Sci 2001;16(2):141-147.

21. Huber TS, Seeger JM. Contribution of the Southern Association for Vascular Surgery to the scientific literature. J Vasc Surg 2001; 34(3):393-396.

22. Huber TS, Seeger JM. Dartmouth Atlas of Vascular Health Care review: impact of hospital volume, surgeon volume, and training on outcome. J Vasc Surg 2001;34(4):751-6.

23. Lee WA, Berceli SA, Huber TS, Seeger JM. A technique for combined hypogastric artery bypass and endovascular repair of complex aortoiliac aneurysms. J Vasc Surg 2002;35(6):1289-1291.

24. Rectenwald JF, Huber TS, Martin TD, Ozaki CK, Welborn MB, Flynn TC, Seeger JM. Functional Outcome After Thoracoabdominal Aneurysm Repair. J Vasc Surg 2002;35(4):640-647.

25. Huber TS, Ozaki CK, Jimenez JG, Lee WA, Berceli SA, Seeger JM. Durability of antegrade, synthetic aortomesenteric bypass for chronic mesenteric ischemia. J Vasc Surg 2002;35(6):1078-84.

26. Rectenwald JE, Minter RM, Moldawer LL, Abouhamze BS, La Face D, Hutchins E, Huber TS, Seeger JM, Ozaki CK. Interleukin-10 Fails to Modulate Low Shear Stress-Induced Neointimal Hyperplasia. J Surg Res 2002;102:110-118.

27. Lee WA, Huber TS, Hirneise CM, Berceli SA, Seeger JM. Eligibility rates of ruptured and symptomatic AAA for endovascular repair. J Endovasc Therapy 2002;9:436-442.

28. Huber TS, Ozaki CK, Flynn TC, Lee WA, Berceli SA, Hirneise CM, Carlton LM, Carter JW, Ross EA, Seeger JM. Prospective Validation of on Algorithm to Maximize Native Arteriovenous Fistulae For Chronic Hemodialysis Access. J Vasc Surg 2002;36(3):452-459.

29. Huber TS, Seeger JM. Approach to patients with "complex" hemodialysis access problems. Semin Dial 2003;16(1):22-9.

30. Welborn MB 3rd, Moldawer LL, Seeger JM, Minter RM, Huber TS. Role of endogenous interleukin-10 in local and distant organ injury after visceral ischemia-reperfusion. Shock 2003;20(1):35-40.

31. Seeger JM. Leadership in difficult times. J Vasc Surg 2003;38(3):413-21.

32. Lee WA, Berceli SA, Huber TS, Ozaki CK, Flynn TC, Seeger JM. Morbidity with retroperitoneal procedures during endovascular abdominal aortic aneurysm repair. J Vasc Surg 2003;38(3):459-63.

33. Levin DC, Becker GJ, Dorros G, Goldstone J, King SB 3rd, Seeger JM, Spies JB, Spittell JA Jr., Wexler L, Councils on Cardiovascular Radiology, Cardiothoracic and Vascular Surgery, and Clinical Cardiology, American Heart Association. Training standards for physicians performing peripheral angioplasty and other percutaneous peripheral vascular interventions. J Vasc Interv Radiol 2003;14(9pt2):S359-61.

34. Huber TS, Carter JW, Carter RL, Seeger JM. Patency of autogenous and polytetrafluoroethylene upper extremity arteriovenous hemodialysis accesses: a systemic review. J Vasc Surg 2003;38(5):1005-11.

35. Lee WA, Carter JW, Upchurch G, Seeger JM, Huber TS. Perioperative outcomes after open and endovascular repair of intact abdominal aortic aneurysms in the United States during 2001. J Vasc Surg 2004;39(3):491-6.

36. Feezor RJ, Baker HV, Xiao W, Lee WA, Huber TS, Mindrinos M, Kim RA, Ruiz-Taylor L, Moldawer LL, Davis RW, Seeger JM. Genomic and proteomic determinants of outcome in patients undergoing thoracoabdominal aortic aneurysm repair. J Immunol 2004;172(11):7103-9.

37. Huber TS, Buhler AG, Seeger JM. Evidence-based data for the hemodialysis access surgeon. Semin Dial 2004;17(3):217-23.
 

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