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The Surgical Laboratory for Tissue Engineering is headed by Dr. Mike
Chen and is located in room N5-11 in the Medical Sciences Building.
Laboratory work began in 2001. The focus of the laboratory is on the creation of new intestinal tissue using native intestine and biomaterials in an animal model. This is an effective model for identifying biomaterials that may be useful for tissue regeneration. The function and contribution of stem cells to intestinal regeneration may be evaluated using this model.
Research has shown that fibrin glue, polyglycolic acid, and small intestinal submucosa may serve as scaffolds for intestinal regeneration.
Current focus is on identifying the contribution of host and donor stem cells in the regeneration of the novel intestinal tissue.
FUNDING:
Principal Investigator, 2000 Children's Miracle Network Award, Creation of Neointestine through Bioengineering.
Grant # 2000F-013; 01/31/01-01/31/02.
Total Award: $14,660.
Principal Investigator, 2001 Children's Miracle Network Award, Effects of Growth Factors on Bioengineered Neointestine.
Grant # 2001-055; 01/31/02-01/31/04.
Total Award: $19,142.
Principal Investigator, 2003 Children's Miracle Network Award. Role of Stem Cells in Intestinal Tissue Engineering.
Grant # 2003-049: 01/31/04-01/31/05
Total Award: $19600.
PUBLICATIONS:
1.
Badylak SF, Meurling S, Chen M, Spievack A, Simmons-Byrd A: Resorbable bioscaffold for esophageal repair in a dog model. J Pediatr Surg 35:1097-1103, 2000.
2. Chen MK and Badylak SF: Small bowel tissue engineering using small intestinal submucosa as a scaffold. J Surg Res 99:352-358, 2001.
3. Chen MK, Beierle EA: Animal models for intestinal tissue engineering. Biomaterials, 25:1675-1681, 2004.
CONTACT INFORMATION:
Phone #: (352) 392-3718
Fax #: (352) 392-9081
E-mail: chenmk@surgery.ufl.edu
Mailing Address:
Michael K. Chen, MD
Assistant Professor of Surgery and Pediatrics
University of Florida, Department of Surgery
PO 100286
Gainesville, FL 32610-0286
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