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The Vascular Biology Research Laboratories are headed by Dr. Keith
Ozaki and Dr. Scott Berceli. The laboratory spaces are located in the Malcom Randall VAMC,
rooms D-121, D-123, D-124, D-125. The laboratory was founded in 1982.
CLINICAL RESEARCH RESOURCES:
· Seven full time vascular surgery attendings performing approximately 1,700 cases per year. We screen/treat approximately 95 patients/month with documented cerebrovascular occlusive disease, 200/month with coronary artery disease, and 250/month with peripheral vascular occlusive disease. We evaluate over 100 patients/month with diabetes, and perform approximately
250 dialysis access procedures per year. Practice includes a large tertiary care University Hospital (Shands at the University of Florida) and the Malcom Randall VAMC (only facility in the entire North Florida/South Georgia Veterans Health System that provides vascular care).
· Four full time trained research nurses with appropriate computer/office support, designated patient care space. Complete functional clinical database in place.
· Three full time physician extenders
· Dedicated Endovascular Operative Suite under OR/Surgery management,
has State-of-the-art biplanar fixed fluoroscopy unit
MAJOR CLINICAL RESEARCH TRIALS:
Open vs Endovascular Aneurysm Repair (OVER)
2002 - 2010 VA Cooperative Studies Program, VA CSP #498 (estimated $300,000). Patient recruitment on target.
Multiple
endovascular device trials, including:
-Anaconda Phase II Aortic Endograft Phase II
-Zenith Fenestrated/Branched Endograft Trial
-Trivascular
Stent Graft System Phase I Clinical Trial
Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA)
2002 - 2005 Sponsor: Sanofi-Synthelabo and Bristol-Myers Squibb (estimated $150,000). Includes a DNA banking sub-study. Patient recruitment concluded, site above expected recruitment.
Pivotal Trial for the VALOR Talent Thoracic Stent Graft System
2003 - 2004 Medtronic, Inc. (estimated $80,000). Patient recruitment commenced Winter, 2003.
The Iron (Fe) and Atherosclerosis Study (FeAST)
1999 - 2004 VA Cooperative Studies Program, VA CSP #410 (estimated $500,000; faculty participates on National Executive Steering Committee). Includes a DNA banking sub-study. Patient recruitment completed, site 135% of predicted, 4th leading site out of 25 sites nationally
Excluder Thoracic Aortic Endoprosthesis Multicenter Pivotal Trial
2000 W. L. Gore & Associates, Inc. 6th leading recruitment center out of 20. Study terminated
BASIC RESEARCH RESOURCES:
· 2 full time research technicians, multiple graduate and undergraduate students
· 1 dedicated M.D./Ph.D. Research Coordinator
· Two fully equipped labs with separate office space, BSL II operating suite with microsurgery capabilities
· Active collaborations locally with Departments of Engineering, Biomechanical Engineering, Surgery, Pediatric Cardiology
· National and International collaborators include Harvard Medical School, University of Freiburg (Germany)
· Currently 2 NIH active awards, one additional currently under review
MAJOR BASIC RESEARCH SUPPORT:
Mechanisms of Shear Regulated Vein Graft Remodeling
2004 - 2009 National Institutes of Health 1 K08 HL76453-01, Lifeline Foundation, The William J. von Liebig Foundation ($944,825)
Cytokine Driven Mechanisms of Vein
Graft Failure2005 - 2010 National Institutes of Health
1R01HL079135-01 ($1,125,000)
Inflammatory Mechanisms of Neointimal Hyperplasia
2000 - 2005 National Institutes of Health 1 K08 HL04070-01A1, Lifeline Foundation, The William J. von Liebig Foundation ($991,950)
Mechanisms of Vein Graft Remodeling-Effect of Wall Tension and Shear Stress
2002 - 2005 The Whitaker Foundation ($233,052)
Selectin Dependent Mechanisms of the Arterial Response to Injury
1999 - 2002 VA Merit Review Entry Program ($148,300)
1998 - 1999 Howard Hughes Medical Institute Research Resources Program Grant ($20,000)
1998 - 1999 University of Florida College Investment Fund ($20,000)
Mechanisms of Altered Leukocyte Rheology in Diabetes
1999 - 2000 The Whitaker Foundation/University of Florida Biomedical Engineering Program ($14,923)
Radiation Therapy for Improved Dialysis Access Patency
1998 - 2000 Gore Grant Program, W.L. Gore & Associates, Inc. ($22,023)
Flow Mediated Arterial and Vein Graft Remodeling
2000-2002 Howard Hughes Medical Institute Research Resources Program Grant ($50,000)
Mechanisms of Flow Induced Intimal Regression
2002 Association for Academic Surgery Faculty Research Award ($30,000)
PUBLICATIONS:
1.
Jiang
Z, Berceli SA, Pfahnl CL, Wu L, Miller BL, Ozaki CK. Differential
temporal expression and wall shear stress modulation of
TNF-a
and IL-10 expression-impact on remodeling. Submitted.
2.
Berceli SA, Jiang Z,
Kilingman NV, Schultz GS, Ozaki CK. Flow regulation of MMP-2 and -9
during arterial and vein graft adaptations. Submitted.
3.
Zacharski LR, Chow BK,
Howes PS, Lavori PW, Shamayeva G, Baron JA, Dalman RL, Malenka DJ,
Ozaki CK. Reduction of iron stores by phlebotomy in peripheral
vascular disease: protocol compliance and toxicity. VA Cooperative
Study #410: The Iron (Fe) and Atherosclerosis Study (FeAST).
Submitted.
4.
Berceli SA, Jiang Z,
Klingman N, Pfahnl CL, Abouhamze ZS, Frase C, Schultz GS, Ozaki CK.
Differential expression and activity of MMPs during flow-modulated
vein graft remodeling. J Vasc Surg 2004;39:1084-1090.
5.
Hoefer IE, van Royen N,
Rectenwald JE, Deindl E, Hua J, Jost M, Heil M, Grundmann
MV,
Ozaki CK, Piek JJ, Buschman IR.
Arteriogenesis
proceeds via ICAM-1/Mac-1 mediated mechanisms. Circ. Res
2004;94:1179-1185.
6.
Jiang Z, Berceli SA,
Pfahnl CL, Wu L, Goldman DR, Tao M, Kagayama M,
Matsukawa
A, Ozaki CK. Wall shear modulation of cytokines in the early vein
graft. J Vasc Surg 2004;40:345-350.
7.
Jiang Z, Berceli SA, Pfahnl CL, Wu L, Killingsworth CD, Vieira FG,
Ozaki CK. Impact of IL-1b on flow induced outward arterial
remodeling. Surgery 2004;136:478-482.
8.
Perrault-Dematte CM, Bray EJ, Didier N,
Ozaki CK, Tran-Son-Tay R. Altered rheology of lymphocytes in
diabetic mice.
Diabetologia
2004;47(10):1722-1726.
9.
Fernandez CM, Goldman DR, Jiang Z, Ozaki CK, Tran-Son-Tay R,
Berceli SA. Impact of shear stress on early vein graft remodeling:
a biomechanical analysis. Ann Biomed Eng
2004;32(11):1484-1493.
10. Grundmann
S, Hoefer I, Ulusans S, van Royen N, Schirmer S, Ozaki CK, Bode C,
Piek JJ, Buschmann I. Anti-Tumor necrosis factor-a therapies
attenuate adaptive arteriogenesis in rabbits. Am J Physiol Heart
Circ Physiol. 2005 May 27.
11. Lee WA, Berceli SA, Huber TS, Ozaki CK, Flynn TC, Seeger JM. Morbidity of retroperitoneal procedures during endovascular AAA repair. J Vasc Surg 2003;38:459-465.
12. Jiang Z, Wu L, Miller BL, Goldman DR, Fernandez CM, Abouhamze ZS, Ozaki CK, Berceli SA. A novel vein graft model: adaptation to differential flow environments. Am J Physiol Heart Circ Physiol. 2004; 286(1):H240-5.
13. Berceli SA, Jiang Z, Klingman N, Pfahnl CL, Abouhamze ZS, Frase C, Schultz GS, Ozaki CK. Differential expression and activity of MMPs during flow-modulated vein graft remodeling. In press, J Vasc Surg.
14. Welborn MB 3rd, Moldawer LL, Seeger JM, Minter RM, Huber TS. Role of endogenous interleukin-10 in local and distant organ injury after visceral ischemia-reperfusion. Shock, 2003; 20(1):35-40.
15. Huber TS, Seeger JM. Approach to patients with "complex" hemodialysis access problems. Semin Dial. 2003; 16(1):22-9.
16. Huber TS, Ozaki CK, Flynn TC, Lee WA, Berceli SA, Hirneise CM, Carlton LM, Carter JW, Ross EA, Seeger JM. Prospective Validation of an algorithm to maximize arteriovenous fistulae for dialysis access. J Vasc Surg, 2002;36(3):452-459.
17. Lee WA, Huber TS, Hirneise CM, Berceli SA, Seeger JM. Eligibility rates of ruptured and symptomatic AAA for endovascular repair. J Endovasc Ther. 2002 Aug;9(4):436-42.
18. Hoefer IE, van Royen N, Rectenwald JE, Bray EJ, Abouhamze Z, Moldawer LL, Vokuil M, Piek JJ, Buschmann IR, Ozaki CK. Direct evidence for TNF-a signaling in arteriogenesis. Circulation, 2002;105:1639-1641.
19. Lee WA, Berceli SA, Huber TS, Seeger JM: A technique for combined hypogastric artery bypass and endovascular repair of complex aortoiliac aneurysms. J Vasc Surg 2002;35:1289-1291.
20. Rectenwald JE, Minter RM, Moldawer LL, Abouhamze Z, La Face D, Hutchins E, Huber TS, Seeger JM, Ozaki CK. Interleukin-10 fails to modulate low shear stress induced neointimal hyperplasia. J Surg Res, 2002;102(2):110-118.
21. Rectenwald JE, Huber TS, Martin TD, Ozaki CK, Devidas M, Welborn MB, Seeger JM. Functional outcome after thoracoabdominal aortic aneurysm repair. J Vasc Surg, 2002;35(4):640-647.
22. Jiminez JG, Huber TS, Ozaki CK, Flynn TC, Berceli SA, Lee WA, Seeger JM. Durability of antegrade synthetic aortomesenteric bypass for chronic mesenteric ischemia. J Vasc Surg, 2002;35(6):1078-1084.
23. Huber TS, Wang JG, Derrow AE, Dame DA, Ozaki CK, Zelenock GB, Flynn TC, Seeger JM. Experience in the United States with intact abdominal aneurysm repair. J Vasc Surg, 2001;33:304-311.
24. Derrow AE, Seeger JM, Dame DA, Carter RL, Ozaki CK, Flynn TC, Huber TS. The outcome in the United States after thoracoabdominal aortic aneurysm repair, renal artery bypass, and mesenteric revascularization. J Vasc Surg, 2001;34:54-61.
25. Rectenwald JE, Pretus HA, Seeger JM, Huber TS, Mendenhall NP, Zlotecki RA, Palta JR, Li ZF, Hook SY, Sarac TP, Welborn MB, Klingman NV, Abouhamze ZS, Ozaki CK. Radiation therapy for improved dialysis access patency: feasibility and early safety. Radiation Research. 2001;156:53-60.
26. Lee WA, Rubin GD, Arko F, Hill BB, Zarins CK: Endovascular stent graft repair of an infrarenal AAA with a horseshoe kidney. Circulation 2001;103:2126-2127.
27. Lee WA, O'Dorisio J, Wolf YG, Hill BB, Fogarty TJ, Zarins CK: Outcome after unilateral hypogastric artery occlusion during endovascular aneurysm repair. J Vasc Surg 2001;33:921-926.
28. Arko FR, Lee WA, Hill BB, Olcott C, IV, Harris EJ, Dalman RL, Fogarty TJ, Zarins CK: Impact of endovascular repair on open aortic aneurysm surgical training. J Vasc Surg 2001;34:885-891.
29. Arko FR, Lee WA, Hill BB, Cipriano P, Fogarty TJ, Zarins CK: Increased flexibility of AneuRx stent graft reduces need for secondary intervention following endovascular aneurysm repair. J Endovasc Ther 2001;8:583-591.
30. Huber TS, Ozaki CK, Flynn TC, Ross EA, Seeger JM. Case Report: Use of superficial femoral vein for hemodialysis arteriovenous shunt. J Vasc Surg, 2000;31:1038-1041.
31. Huber TS, Carlton LM, O'Hern DG, Hardt NS, Ozaki CK, Flynn TC, Seeger JM. Financial impact of tertiary care in an academic medical center. Ann of Surg, 2000 231(6):860-868.
32. Seeger JM, Pretus HA, Welborn MB, Ozaki CK, Flynn TC, Huber TS. Long-term outcome after treatment of aortic graft infection with staged extra-anatomic bypass and aortic graft removal. J Vasc Surg, 2000;32(3):451-459.
33. Rectenwald JE, Moldawer LL, Huber TS, Seeger JM, Derrow AE, Warren JA, Ozaki CK. Direct evidence for TNF-a and IL-1 involvement in neointimal hyperplasia. Circulation, 2000;102:1697-1702.
34. Lee WA, Wolf YG, Fogarty TJ, Zarins CK: Does complete aneurysm exclusion ensure long-term success following endovascular repair? J Endovasc Ther 2000;7:494-500
35. Huber TS, Wang JG, Cuddeback JK, Dame DA, Ozaki CK, Flynn TC, Seeger JM. Impact of race on treatment for peripheral arterial occlusive disease. J Vasc Surg. 1999;30(3):417-426.
36. Seeger JM, Pretus HA, Carlton LM, Flynn TC, Ozaki CK, Huber TS. Potential predictors of outcome in patients with tissue loss who undergo infrainguinal bypass. J Vasc Surg, 1999;30(3):427-435.
37. Ozaki CK, Irwin PB, Flynn TC, Huber TS, Seeger. Surgical decision making for carotid endarterectomy and contemporary magnetic resonance angiography. Am J Surg, 1999;178(3):182-184.
38. Huber TS, Flynn TC, Ozaki CK, Seeger JM. Utility of laparoscopy for identification of hepatic disease before aortic surgery. Vascular Surgery, 1999;33;471-479.
39. Farrehi PM, Ozaki CK, Carmeliet P, Fay WP. Regulation of arterial thrombolysis by plasminogen activator inhibitor-1 in mice. Circulation, 1998; 97(10):1002-1008.
40. Sarac TP, Huber TS, Back MS, Ozaki CK, Carlton LM, Flynn TC, Seeger JM. Warfarin improves outcome of infrainguinal vein bypass grafts at high risk for failure. J Vasc Surg, 1998;28:446-457.
CONTACT INFORMATION:
Phone #: (352) 376-1611 ext. 6231
Fax #: (352) 271-4510
E-mail: ozakick@surgery.ufl.edu
or bercesa@surgery.ufl.edu
Mailing Address:
Keith Ozaki, MD or Scott Berceli, MD, PhD
Department of Surgery
University of Florida
PO Box 100286
Gainesville, FL 32610-0286
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